THE ROLE OF CYTOREDUCTIVE SURGERY (CRS) AND INTRAPERITONEAL INTRAOPERATIVE CHEMOTHERAPY (IIC) IN THE TREATMENT OF PERITONEAL CARCINOMATOSIS FROM COLORECTAL ORIGIN
https://doi.org/10.33878/2073-7556-2017-0-1-53-58
Abstract
AIM. To assess early results and survival in patients with CRS and IIC strategy. METHOD. 56 CRC with PC patients underwent CRS+IIC. pT4 stage occurred in 38 (67,5 %) pts. N+ status was detected in 39 (69 %) cases. In 44 (79 %) pts. carcinomatosiswas synchronous. PCI was rangedfrom 1 to 21 (Me=3). RESULTS. Mortality and morbidity rate in postoperative 30 days was 0 % and 14 %, respectively. The median disease-free survival (DFS) was 21 months. Multivariate analysis revealed that PCI (p=0,0007) and the presence of extraperitoneal metastases (p=0,0097) were independent negative predictors of DFS. The empirical analysis showed that level of PCI more than 8 was the predictor of negative prognosis (p=0,044). CONCLUSION. It has been shown that poor prognosis factors were PCI more than 8, and the presence of distant extraperitoneal metastases of CRC.
About the Authors
Y. A. Shelygin
State Scientific Centre of Coloproctology
Russian Federation
Russian Federation
S. I. Achkasov
State Scientific Centre of Coloproctology
Russian Federation
Russian Federation
O. I. Sushkov
State Scientific Centre of Coloproctology
Russian Federation
Russian Federation
A. A. Ponomarenko
State Scientific Centre of Coloproctology
Russian Federation
Russian Federation
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For citations:
Shelygin Y.A., Achkasov S.I., Sushkov O.I., Ponomarenko A.A. THE ROLE OF CYTOREDUCTIVE SURGERY (CRS) AND INTRAPERITONEAL INTRAOPERATIVE CHEMOTHERAPY (IIC) IN THE TREATMENT OF PERITONEAL CARCINOMATOSIS FROM COLORECTAL ORIGIN. Koloproktologia. 2017;(1):53-58. (In Russ.) https://doi.org/10.33878/2073-7556-2017-0-1-53-58
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