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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gnck</journal-id><journal-title-group><journal-title xml:lang="ru">Колопроктология</journal-title><trans-title-group xml:lang="en"><trans-title>Koloproktologia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-7556</issn><issn pub-type="epub">2686-7303</issn><publisher><publisher-name>Russian Association of Coloproctology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33878/2073-7556-2017-0-1-53-58</article-id><article-id custom-type="elpub" pub-id-type="custom">gnck-296</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>РОЛЬ ЦИТОРЕДУКТИВНОЙ ХИРУРГИИ И ВНУТРИБРЮШНОЙ ИНТРАОПЕРАЦИОННОЙ ХИМИОТЕРАПИИ В ЛЕЧЕНИИ РАКА ТОЛСТОЙ КИШКИ С ПЕРИТОНЕАЛЬНЫМ КАРЦИНОМАТОЗОМ</article-title><trans-title-group xml:lang="en"><trans-title>THE ROLE OF CYTOREDUCTIVE SURGERY (CRS) AND INTRAPERITONEAL INTRAOPERATIVE CHEMOTHERAPY (IIC) IN THE TREATMENT OF PERITONEAL CARCINOMATOSIS FROM COLORECTAL ORIGIN</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шелыгин</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shelygin</surname><given-names>Y. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ачкасов</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Achkasov</surname><given-names>S. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сушков</surname><given-names>О. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Sushkov</surname><given-names>O. I.</given-names></name></name-alternatives><email xlink:type="simple">info@gnck.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пономаренко</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ponomarenko</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «ГНЦК им. А.Н.Рыжих» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Scientific Centre of Coloproctology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>30</day><month>03</month><year>2017</year></pub-date><volume>0</volume><issue>1</issue><fpage>53</fpage><lpage>58</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шелыгин Ю.А., Ачкасов С.И., Сушков О.И., Пономаренко А.А., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Шелыгин Ю.А., Ачкасов С.И., Сушков О.И., Пономаренко А.А.</copyright-holder><copyright-holder xml:lang="en">Shelygin Y.A., Achkasov S.I., Sushkov O.I., Ponomarenko A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ruproctology.com/jour/article/view/296">https://www.ruproctology.com/jour/article/view/296</self-uri><abstract><p>ЦЕЛЬ. Оценить непосредственные результаты лечения и выживаемость пациентов, оперированных по поводу рака толстой кишки (РТК) с перитонеальным карциноматозом (ПК). МАТЕРИАЛЫ И МЕТОДЫ. В анализ включено 56 больных, которым выполнены циторедуктивные операции и внутрибрюшная химиотерапия по поводу РТК с ПК. рТ4-стадия первичной опухоли была диагностирована в 38/56 (67,5 %), а метастазы в лимфатические узлы обнаружены в 39/56 (69%) макропрепаратах. Медиана перитонеального карциноматозного индекса (ПКИ) составила 3 (1;5). РЕЗУЛЬТАТЫ. Смертность и частота развития послеоперационных осложнений в 30-дневный период после операции составили 0 % и14%, соответственно. Медиана безрецидивной выживаемости (БВ) была 21 (11;н/д) месяц. При многофакторном анализе установлено, что уровень ПКИ (р=0,0007) и наличие внебрюшинных метастазов (р=0,0097) - независимые неблагоприятные прогностические факторы БВ. При эмпирическом анализе пограничное значение ПКИ, при котором выявились достоверные различия (р=0,044) во времени возникновения рецидива, оказался равен 8. Медиана БВ при уровне ПКИ менее 8 оказалась равна 24 (11;н/д) месяцам., а более 8-10 (7;17) месяцев. ВЫВОДЫ. Циторедуктивные операции (ЦО) вместе с интраоперационной внутрибрюшной химиотерапией (ВБХТ) у больных РТК с ПК при низком уровне послеоперационных осложнений и нулевой летальности позволяют достичь увеличения БВ у пациентов с ПКИ менее 8 более, чем в 2 раза, по сравнению с пациентами, у которых ПКИ был выше этого значения.</p></abstract><trans-abstract xml:lang="en"><p>AIM. To assess early results and survival in patients with CRS and IIC strategy. METHOD. 56 CRC with PC patients underwent CRS+IIC. pT4 stage occurred in 38 (67,5 %) pts. N+ status was detected in 39 (69 %) cases. In 44 (79 %) pts. carcinomatosiswas synchronous. PCI was rangedfrom 1 to 21 (Me=3). RESULTS. Mortality and morbidity rate in postoperative 30 days was 0 % and 14 %, respectively. The median disease-free survival (DFS) was 21 months. Multivariate analysis revealed that PCI (p=0,0007) and the presence of extraperitoneal metastases (p=0,0097) were independent negative predictors of DFS. The empirical analysis showed that level of PCI more than 8 was the predictor of negative prognosis (p=0,044). CONCLUSION. It has been shown that poor prognosis factors were PCI more than 8, and the presence of distant extraperitoneal metastases of CRC.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>карциноматоз</kwd><kwd>рак толстой кишки</kwd><kwd>циторедуктивная операция</kwd><kwd>внутрибрюшная химиотерапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>carcinomatosis</kwd><kwd>colorectal cancer</kwd><kwd>cytoreductive surgery</kwd><kwd>intraperitoneal chemotherapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Беляев А.М. Циторедуктивные операции и гипертермическая внутрибрюшинная химиотерапия в комплексном лечении распространенных форм интраабдоминального рака. Дис.. докт. мед. наук. - СПб., 2004. - 312 с.</mixed-citation><mixed-citation xml:lang="en">Беляев А.М. 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