Methemoglobinemia in the postoperative period against the background of taking Almagel (clinical case)
https://doi.org/10.33878/2073-7556-2023-22-3-129-133
Abstract
Methemoglobinemia were recorded in two patients with intestinal paresis and gastrostasis in the early postoperative period and unauthorized intake of Almagel by patients for the relief of heartburn.
In the presented cases, drugs that can cause methemoglobinemia were used in the treatment: ropivacaine, metoclopramide, ketoprofen. Nevertheless, taking into account the pairing of the presented cases, it is impossible to exclude the effect of the drug Almagel on methemoglobin genesis.
CONCLUSION: the presented cases demonstrate manifestations of rare and poorly recognized drug methemoglobinemia, probably as a result of taking the antacid drug Almagel. Timely diagnosis and treatment of this condition ensures the rapid reversibility of a complex multifactorial biochemical process.
About the Authors
Artem V. VolkovRussian Federation
Artem V. Volkov — Candidate of Medical Sciences, coloproctologist; Associate Professor of the Department of General Surgery
1 May st., 167, Krasnodar, 350086
Sedina st., 4, Krasnodar, 350063
V. V. Polovinkin
Russian Federation
Vadim V. Polovinkin — MD, Head of the Department of Coloproctology; Head of the Department of General Surgery
1 May st., 167, Krasnodar, 350086
Sedina st., 4, Krasnodar, 350063
References
1. Shperling I.A., Ryazantseva N.V., Kuprina N.P. et al. On the composition of membrane-bound hemoglobin in methemoglobinemia. Modern high-tech technologies. 2004; 6:104-105. (in Russ.). doi: http://econf.rae.ru/article/381
2. Canning J, Levine M. Case files of the medical toxicology fellowship at Banner Good Samaritan Medical Center in Phoenix, AZ: methemoglobinemia following dapsone exposure. J Med Toxicol. 2011; 7 (2): 139-146. doi: 10.1007/s13181-011-0151-9.
3. Douglas WW, Fairbanks VF. Methemoglobinemia induced by a topical anesthetic spray (cetacaine). Chest. 1977; 71 (5):587-591. doi: 10.1378/chest.71.5.587.
4. Kazanets E.G. Methemoglobinemia. Children's Hospital. 2009; 1:38-42. (in Russ.). http://www.technomedica.ru/site_files/docs/technomedika/polyhem/methemoglobinimii.pdf
5. Gay HC, Amaral АP. Acquired methemoglobinemia associated with topical lidocaine administration: a case report. Drug Saf Case Rep. 2018; 5(1):15. doi: 10.1007/s40800-018-0081-4.
6. Rehman HU. Methemoglobinemia. West J Med. 2001; 175:193–196. doi: 10.1136/ewjm..3.193175
7. Kwok S, Fischer JL, Rogers JD. Benzocaine and lidocaine induced methemoglobinemia after bronchoscopy: a case report. J Med Case Rep. 2008;2:16. doi: 10.1186/1752-1947- 2-16.
8. Wright RO, Lewander WJ, Woolf AD. Methemoglobinemia: etiology, pharmacology, and clinical management. Ann Emergmed. 1999;34(5):646–656. doi: 10.1016/S0196-0644(99)70167-8
9. Guay J. Methemoglobinemia Related to Local Anesthetics: A Summary of 242 Episodes. Anesthesia & Analgesia. 2009 March; 108(3):837-845. doi: 10.1213/ane.0b013e318187c4b1
10. McLean S, Murphy BP, Starmer GA, et al. Methemoglobin formation induced by aromatic amines and amides. J Pharm Pharmacol. 1967 Mar;19(3):146-54. doi: 10.1111/j.2042-7158.1967.tb08056.x.
11. Starkov Yu.G., Kazennov V.V., Vyborny M.I., et al. The development of severe methemoglobinemia against the background of taking almagel A. Experimental and clinical gastroenterology. 2014; 7:91-93. (in Russ.).
12. Tepaev R.F., Vishnevsky V.A., Kuzin S.A. et al. Methemoglobinemia associated with benzocaine intake. Clinical case. Pediatric pharmacology. 2018; 15(5): 396-401. (in Russ.). doi: 10.15690/pf.v15i5.1962.
13. Tolmacheva E.A. Handbook Vidal 2022. medicinal products in Russia. "Publishing house" Vidal Rus". 2022. (in Russ.). doi: https://www.vidal.ru/drugs/almagel__6701
14. Habib Ur Rehman. Methemoglobinemia. West J Med. 2001 Sep; 175(3): 193–196. doi: 10.1136/ewjm.175.3.193
15. Emelyanova E.A., Asekritova A.S., Moyakunov D.A. Methemoglobinemia induced by almagel A. Modern problems of science and education. 2021; 6. (in Russ.). doi: https://science-education.ru/ru/article/view?id=31340
16. Vorobyev A.M. Guide to hematology in 3 volumes. "Publishing house "New diamed". 2007. (in Russ.).
Review
For citations:
Volkov A.V., Polovinkin V.V. Methemoglobinemia in the postoperative period against the background of taking Almagel (clinical case). Koloproktologia. 2023;22(3):129-133. https://doi.org/10.33878/2073-7556-2023-22-3-129-133