Эффективность и безопасность озанимода в лечении язвенного колита (обзор литературы)
https://doi.org/10.33878/2073-7556-2022-21-3-119-129
Аннотация
Язвенный колит является хроническим аутоиммунным заболеванием кишечника, которое на сегодняшний день не имеет способов излечения, кроме хирургического. Применение различных лекарственных препаратов у ряда пациентов оказывается неэффективным или приводит к развитию тех или иных нежелательных явлений, требующих смены терапии. Существует неудовлетворенная потребность в новых лекарственных препаратах принципиально отличающихся по механизму действия, но показывающих высокую эффективность и безопасность. Озанимод, являясь модулятором рецептора сфингозин-1-фосфата, предотвращает проникновение лимфоцитов, тем самым снижая воспаление в кишечнике. В статье представлен обзор данных по механизму действия данного препарата, его эффективности и безопасности в лечении язвенного колита, как у бионаивных пациентов, так и у тех, кто не ответил на лечение другими биологическими препаратами.
Об авторах
М. В. Шапина
ФГБУ «НМИЦ колопроктологии имени А.Н. Рыжих» Минздрава России
Россия
Россия
ул. Саляма Адиля, д. 2, г. Москва, 123423
А. В. Полетова
ФГБУ «НМИЦ колопроктологии имени А.Н. Рыжих» Минздрава России
Россия
Россия
ул. Саляма Адиля, д. 2, г. Москва, 123423
Т. А. Баранова
ФГБУ «НМИЦ колопроктологии имени А.Н. Рыжих» Минздрава России
Россия
Россия
ул. Саляма Адиля, д. 2, г. Москва, 123423
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Рецензия
Для цитирования:
Шапина М.В., Полетова А.В., Баранова Т.А. Эффективность и безопасность озанимода в лечении язвенного колита (обзор литературы). Колопроктология. 2022;21(3):119-129. https://doi.org/10.33878/2073-7556-2022-21-3-119-129
For citation:
Shapina M.V., Poletova A.V., Baranova T.A. Efficacy and safety of ozanimod for ulcerative colitis (review). Koloproktologia. 2022;21(3):119-129. https://doi.org/10.33878/2073-7556-2022-21-3-119-129
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