CURRENT PRACTICE OF TRISULFATE APPLYING FOR BOWEL CLEANSING IN ACCORDING TO CLINICAL SAFETY POSITIONS
https://doi.org/10.33878/2073-7556-2020-19-4-93-99
Abstract
High-quality bowel cleansing is the basis for effective colon examination. Inadequate preparation of the colon can be the reason for nondetection of colorectal polyps during the examination and reach 12%. The objective of this publication is to present current literature data based on the principles of evidence-based medicine that address the safety of using trisulfate in preparation for colonoscopy. It was found that the drug for intestinal cleansing, which is a low-volume one-liter hyperosmotic based on a combination of sodium, potassium and magnesium sulfate salts, has a high efficiency of preparing the intestine for colonoscopy. The percentage of patients with successful bowel preparation using trisulfate is 97%. At the same time, the drug has an acceptable safety profile, including for patients from risk groups. The results of this review indicate that the new low-volume one-liter trisulfate is an effective remedy for providing one of the most important indicators of highquality colonoscopy - bowel cleansing and has a high safety profile.
About the Authors
D. V. ZavyalovRussian Federation
prospekt Oktyabrya, 67, Yaroslavl, 150054, Russia
S. V. Kashin
Russian Federation
prospekt Oktyabrya, 67, Yaroslavl, 150054, Russia
References
1. Zav`yalov D.V., Kashin S.V. Propushhenny`e neoplazii tolstoj kishki. Koloproktologia. 2015, no.1(51), pp.32-37. (in Russ.).
2. Knyazev M.V., Scherbakov P.L., Parfenov A.I. Colon cleansing before colonoscopy: balance of effectiveness, safety and accessability of the medications. Endoscopic surgery. 2015; no.3, pp. 30-36. (in Russ.).
3. Mtvralashvili D.A., Veselov V.V., Galyaev A.V. et al. Polyethylene Glycol: Preparation of Patients for Endoscopic Procedures. Lechebnoe delo. 2016; no.3, pp.85-90. (in Russ.).
4. Kostenko N.V., Veselov V.V. Domestic polyetheltneglycol drug in the diagnosis of colonopathies. Farmateca. 2010; nğ.20(213), pp.72-75. (in Russ.).
5. Di Palma JA. A Randomized Clinical Study Evaluating the Safety and Efficacy of a New, Reduced-Volume, Oral Sulfate Colon-Cleansing Preparation for Colonoscopy. Am J Gastroenterol. 2009; 104: 2275-84.
6. Rex DK. A randomized clinical study comparing reduced-volume oral sulfate solution with standard 4-liter sulfate-free electrolyte lavage solution as preparation for colonoscopy gastrointestinal endoscopy. Gastrointest Endosc. 2010 Aug 19;72(2):328-36. Epub 2010 Jun 19.
7. Harrison NM. Bowel cleansing before colonoscopy. World J Gastrointest Endosc. 2016 January 10; 8(1):4-12.
8. Lynn Huynh MPH, Yermakov S, Davis M. et al. Cost-analysis model of colonoscopy preparation using split-dose reduced-volume oral sulfate solution (OSS) and polyethylene glycol with electrolytes solution (PEG-ELS). Journal of Medical Economics. 2016; v.19, Issue 4.
9. Fedorov E.D., Veselov V.V., Kashin S.V., Tikhomirova E.V., et al. Assessment of Bowel Preparation Using Low-Volume SulphateBased Preparations in Comparison with Macrogols: A Multicenter, Randomized, Comparative Clinical Study of the 3rd Phase. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2019; no.29(2), pp.60-75. (In Russ.)
10. Khitaryan A.G., Kovalev S.A., Romodan N.A. et al. The first results of one day preparation with sulfate-based hyperosmotic solution as a preparatory stage for performing endoscopic examinations and (or) surgical treatment on the colon. Koloproktologia. 2019; v.18, no. S3 (69), p.103. (in Russ.).
11. Pelham RW. A Pharmacokinetics Evaluation of a New, Low-Volume, Oral Sulfate Colon Cleansing Preparation in Patients With Renal or Hepatic Impairment and Healthy Volunteers. J Clin Pharmacol. 2010;50:350-354.
12. Pаtel V. Intestinal and Renal Effects of Low-Volume Phosphate and Sulfate Cathartic Solutions Designed for Cleansing the Colon: Pathophysiological Studies in Five Normal Subjects. The American Journal of Gastroenterology. 2009; v. 104, Issue 4, p.953-965. DOI: 10.1038/ajg.2008.124
13. Cole DE, Thurgood AM, Whiting SJ. Increased serum sulfate after protein loading in adult humans. Can J Physiol Pharmacol. 1991; 69: 25-27.
14. Cole DE, Evrovski J. The clinical chemistry of inorganic sulfate. Crit Rev Clin Lab Sci. 2000; 37: 299-344
15. Anastassopoulos K, Farraye FA, Knight T. et al. A Comparative Study of Treatment-Emergent Adverse Events Following Use of Common Bowel Preparations Among a Colonoscopy Screening Population: Results from a Post-Marketing Observational Study. Dig Dis Sci. 2016;61(10):2993-3006.
16. Moulin B, Ponchon T. A comparative review of use of sulphate and phosphate salts for colonoscopy preparations and their potential for nephrotoxicity. Endosc Int Open. 2018;6(10):E1206-E1213. doi: 10.1055/a-0581-8723
17. Smith JM, Lowe RF, Fullerton J et al. An integrative review of the side effects related to the use of magnesium sulfate for preeclampsia and eclampsia management. BMC Pregnancy Childbirth. 2013; 13:34
18. Saltzman JR, Cash BD, et al. ASGE Standards of Practice Committee. Bowel preparation before colonoscopy. Gastrointest Endosc. 2015; 81:781.
19. FDA - Food and Drug Administration. https://gmpnews.ru/terminologiya/fda/ (date: 29.05.2020)
20. Hassan C, East J, Radaelli F, et al. Bowel preparation for colonoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2019. Endoscopy. 2019;51(8):775-794. doi: 10.1055/a-0959-0505
21. Summary of product characteristics Eziclen (in Russ).
Review
For citations:
Zavyalov D.V., Kashin S.V. CURRENT PRACTICE OF TRISULFATE APPLYING FOR BOWEL CLEANSING IN ACCORDING TO CLINICAL SAFETY POSITIONS. Koloproktologia. 2020;19(4):93-99. (In Russ.) https://doi.org/10.33878/2073-7556-2020-19-4-93-99