CAN FLUORESCENT ANGIOGRAPHY REDUCE THE LEAK RATE OF COLONIC ANASTOMOSES? (a meta-analysis)
https://doi.org/10.33878/2073-7556-2019-18-4-139-150
Abstract
AIM: to evaluate of efficacy of fluorescence angiography (FA) in reducing the anastomotic leakage (AL) rate after colorectal surgery in meta-analysis.
SEARCH STRATEGY: PubMed were searched up to May 2019 for studies comparing fluorescence imaging with standard approach. The primary outcome measure was colorectal anastomotic leakage (AL) rate. The Newcastle-Ottawa scale was used for quality assessment. A meta-analysis with random-effects model was performed to calculate odds ratios (ORs) from the original data.
RESULTS: Two thousand four hundred and sixty-six patients from 7 non-randomized studies and 1 randomized study were included. Fluorescence imaging significantly reduced the AL rate in patients after colorectal surgery (OR 0.58; 95%CI 0.39-0.85; p=0.006) and after rectal cancer surgery (OR 0.28; 95%CI, 0.14-0.55; p=0.0002). A limitation of this meta-analysis is the inclusion of only one randomized study.
CONCLUSION: Fluorescence angiography with indocyanine green is a method of preventing of leakage of colorectal anastomosis. The results of randomized clinical trials are needed to confirm the effectiveness of this technique.
About the Authors
M. V. Alekseev
State Scientific Centre of Coloproctology of the Ministry of Healthcare of Russia
Russian Federation
Russian Federation
123423, Moscow, str. Salyama Adilya, 2
Yu. A. Shelygin
State Scientific Centre of Coloproctology of the Ministry of Healthcare of Russia;
Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia
Moscow
Moscow
E. G. Rybakov
State Scientific Centre of Coloproctology of the Ministry of Healthcare of Russia
Moscow
Moscow
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Review
For citations:
Alekseev M.V., Shelygin Yu.A., Rybakov E.G. CAN FLUORESCENT ANGIOGRAPHY REDUCE THE LEAK RATE OF COLONIC ANASTOMOSES? (a meta-analysis). Koloproktologia. 2019;18(4):139-150. https://doi.org/10.33878/2073-7556-2019-18-4-139-150
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