Treatment of rectal fistulas using autologous fat injections. Is it really so clear? (review)
Elizaveta A. Kuzina, 
Mariyam M. Omarova,
Andrey A. Mudrov,
Alexander Y. Titov,
Viktor K. Obukhov,
Ivan V. Kostarev
Mariyam M. Omarova,
Andrey A. Mudrov,
Alexander Y. Titov,
Viktor K. Obukhov,
Ivan V. Kostarev https://doi.org/10.33878/2073-7556-2026-25-2-149-160
Abstract
The review evaluates current approaches to complex cryptoglandular anorectal fistulas and various outcomes following sphincter-preserving procedures, and assesses the efficacy and safety of various treatment methods. The paper primarily focus on existing applications of stem cells technologies in treatment of cryptoglandular fistulas, critical examining the use of autologous adipose tissue as a source of mesenchymal stem cells. Based on current literature, this method is safe, and minimally invasive, moreover it has significant potential, in the treatment of complex rectal fistulas. However, its implementation in clinical practice requires further research and standardization of both preparation processes and application technology.
About the Authors
Elizaveta A. Kuzina
Ryzhikh National Medical Research Center of Coloproctology
Russian Federation
Russian Federation
Salyama Adilya st., 2, Moscow, 123423
Mariyam M. Omarova
Ryzhikh National Medical Research Center of Coloproctology
Russian Federation
Russian Federation
Salyama Adilya st., 2, Moscow, 123423
Andrey A. Mudrov
Ryzhikh National Medical Research Center of Coloproctology; Russian Medical Academy of Continuous Professional Education
Russian Federation
Russian Federation
Salyama Adilya st., 2, Moscow, 123423
Barrikadnaya st., 2/1, bld. 1, Moscow, 125993
Alexander Y. Titov
Ryzhikh National Medical Research Center of Coloproctology
Russian Federation
Russian Federation
Salyama Adilya st., 2, Moscow, 123423
Viktor K. Obukhov
Russian Medical Academy of Continuous Professional Education
Russian Federation
Russian Federation
Barrikadnaya st., 2/1, bld. 1, Moscow, 125993
Ivan V. Kostarev
Ryzhikh National Medical Research Center of Coloproctology; Russian Medical Academy of Continuous Professional Education
Russian Federation
Russian Federation
Salyama Adilya st., 2, Moscow, 123423
Barrikadnaya st., 2/1, bld. 1, Moscow, 125993
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Review
For citations:
Kuzina E.A., Omarova M.M., Mudrov A.A., Titov A.Y., Obukhov V.K., Kostarev I.V. Treatment of rectal fistulas using autologous fat injections. Is it really so clear? (review). Koloproktologia. 2026;25(2):149-160. (In Russ.) https://doi.org/10.33878/2073-7556-2026-25-2-149-160
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