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Early results of simultaneous laparoscopic operations for colorectal cancer with liver metastases

https://doi.org/10.33878/2073-7556-2025-24-2-52-59

Abstract

AIM: to estimate early results and feasibility of simultaneous laparoscopic procedures for patients with colorectal cancer (CRC) with synchronous liver metastases.

PATIENTS AND METHODS: the pilot study included 11 patients with CRC with synchronous liver metastases. They underwent simultaneous procedures using a laparoscopic approach. The inclusion criteria were morphologically confirmed CRC, synchronous resectable liver mts and somatic status level ASA I-II.

RESULTS: no conversions occurred. The operation time was 194.0 ± 36.5 (170–250) min., intraoperative blood loss was 350.0 ± 175.3 (150–600) ml. Anatomical resections were performed in 7 of 11 cases: hemihepatectomy in 2 cases, bisegmentectomy in 2 cases, and resection of a liver segment in 1 case. The postoperative hospital stay was 9.9 (5–20) days. There were no blood transfusions, there was 1 complication — anastomosis leakage. No mortality occurred.

CONCLUSIONS: simultaneous colorectal resection with liver resection using laparoscopic access is a feasible and safe method if strict patient selection criteria are met.

About the Authors

A. A. Valiev
Republican Clinical Oncology Dispensary of the Ministry of Health of the Republic of Tatarstan named after prof. Sigal M.Z.
Russian Federation

Amir A. Valiev

Sibirskiy trakt, 31, Kazan, 420029



B. I. Gataullin
Republican Clinical Oncology Dispensary of the Ministry of Health of the Republic of Tatarstan named after prof. Sigal M.Z.; Kazan State Medical Academy — branch of the Federal State Budgetary Educational Institution of Further Professional Education “Russian Medical Academy of Continuing Professional Education” of the Ministry of Health of the Russian Federation; Federal State Educational Institution of Higher Education “Institute of Fundamental Medicine and Biology, Kazan Federal University”
Russian Federation

Bulat I. Gataullin

Sibirskiy trakt, 31, Kazan, 420029; Mushtari, 11, Kazan, 420012; Karl Marx st., 76, Kazan, 420012



A. P. Zankina
Republican Clinical Oncology Dispensary of the Ministry of Health of the Republic of Tatarstan named after prof. Sigal M.Z.; Kazan State Medical Academy — branch of the Federal State Budgetary Educational Institution of Further Professional Education “Russian Medical Academy of Continuing Professional Education” of the Ministry of Health of the Russian Federation
Russian Federation

Anna P. Zankina

Sibirskiy trakt, 31, Kazan, 420029; Mushtari, 11, Kazan, 420012



I. G. Gataullin
Republican Clinical Oncology Dispensary of the Ministry of Health of the Republic of Tatarstan named after prof. Sigal M.Z.; Kazan State Medical Academy — branch of the Federal State Budgetary Educational Institution of Further Professional Education “Russian Medical Academy of Continuing Professional Education” of the Ministry of Health of the Russian Federation
Russian Federation

Ilgiz G. Gataullin

Sibirskiy trakt, 31, Kazan, 420029; Mushtari, 11, Kazan, 420012



R. Sh. Khasanov
Kazan State Medical Academy — branch of the Federal State Budgetary Educational Institution of Further Professional Education “Russian Medical Academy of Continuing Professional Education” of the Ministry of Health of the Russian Federation
Russian Federation

Rustem Sh. Khasanov

Mushtari, 11, Kazan, 420012



B. R. Valitov
Republican Clinical Oncology Dispensary of the Ministry of Health of the Republic of Tatarstan named after prof. Sigal M.Z.
Russian Federation

Bulat R. Valitov

Sibirskiy trakt, 31, Kazan, 420029



References

1. Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209–249. doi: 10.3322/caac.21660

2. Starostin B.I., Gataullin B.I., Valitov B.R. Colorectal cancer: epidemiology and risk factors. Povolzhsky Oncological Bulletin. 2021; v.12, 4(48):52–59. (In Russ.).

3. Arnold M, Sierra MS, Laversanne M, et al. Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2017 Apr;66(4):683–691. doi: 10.1136/gutjnl-2015-310912

4. Bray F, Steward BW, Wild CP. Transitions in human development and the global cancer burden. World Cancer Report 2014. Lyon: International Agency for Research on Cancer. 2014; pp.54-68.

5. Xi Y, Xu P. Global colorectal cancer burden in 2020 and projections to 2040. Transl Oncol. 2021;14(10):101174. doi: 10.1016/j.tranon.2021.101174

6. Lyadov V.K., Moskalenko A.N., Britskaya N.N. Laparoscopic resections of the liver and colon for synchronous metastases of colorectal cancer: a series of observations. Modern Oncology. 2022;24(1):61–65. (In Russ.). doi: 10.26442/18151434.2022.1.201433

7. Kaprin A.D., Starinsky V.V., Shakhzadova A.O. Malignant neoplasms in Russia in 2019 (morbidity and mortality). Moscow: P.A. Herzen Moscow Oncology Research Institute − branch of the National Medical Research Center of Radiology of the Ministry of Health of the Russian Federation. 2020; 252 p. (In Russ.).

8. Siegel RL, Miller KD, Goding Sauer A, et al. Colorectal cancer statistics, 2020. CA Cancer J Clin. 2020;70(3):145–164. doi: 10.3322/caac.21601

9. Nozawa H, Ishizawa T, Yasunaga H, et al. Open and/or laparoscopic one-stage resections of primary colorectal cancer and synchronous liver metastases: An observational study. Medicine (Baltimore). 2021;9(3):100–11. doi: 10.1097/MD.0000000000025205

10. Rasulov A. O., Aliev V. A., Podluzhny D. V., et al. . Simultaneous hybrid laparoscopic extirpation of the rectum and open liver resection for cancer with synchronous distant metastases (clinical observation). Oncological Coloproctology . 2016;4(6):45–51. (In Russ.). doi: 10.17650/2220-3478-2016-6-4-45-51

11. Izrailov R.E., Alikhanov R.B., Domrachev S.A. Simultaneous laparoscopic liver resection for synchronous metastases of colorectal cancer. Effective pharmacotherapy. 2013;31:38–40. (In Russ.).

12. Leonard GD, Brenner B, Kemeny NE. Neoadjuvant chemotherapy before liver resection for patients with unresectable liver metastases from colorectal carcinoma. J Clin Oncol. 2005; 20;23(9):2038–48. doi: 10.1200/JCO.2005.00.349

13. Abdalla EK, Vauthey JN, Ellis LM, et al. Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases. Ann Surg. 2004;239(6):818–25. doi: 10.1097/01.sla.0000128305.90650.71

14. Choti MA, Sitzmann JV, Tiburi MF, et. al. Trends in long-term survival following liver resection for hepatic colorectal metastases. Ann Surg. 2002;235(6):759–66. doi: 10.1097/00000658-200206000-00002

15. Abdalla EK, Adam R, Bilchik AJ, et. al. Improving resectability of hepatic colorectal metastases: expert consensus statement. Ann Surg Oncol. 2006;13(10):1271–80. doi: 10.1245/s10434-006-9045-5

16. Hillingso JG, Wille-Jorgensen P. Staged or simultaneous resection of synchronous liver metastases from colorectal cancer — a systematic review. Colorectal Dis. 2009;11(1):3–10. doi: 10.1111/j.1463-1318.2008.01625.x

17. Zabelin M.V., Melnikov P.V., Savenkov S.V., et al. Surgical treatment of colorectal liver metastases: current status and development prospects. Surgical practice. 2015;1:19–26. (In Russ.).

18. Patyutko Yu.I., Sagaydak I.V., Kotelnikov A.G., et al. Liver resection: modern technologies for tumor lesions. Annals of surgical hepatology. 2010;15(2):9–17. (In Russ.).

19. Abdalla EK, Vauthey JN, Ellis LM, et al. Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases. Ann Surg. 2004;239(6):818–825. doi: 10.1097/01.sla.0000128305.90650.71

20. Hardy KJ. Liver surgery: the past 2000 years. Australian and New Zealand Journal of Surgery. 1990;60(10):811–817. doi: 10.1111/j.1445-2197.1990.tb07479.x

21. Jemal A, Murray T, Ward E, et al. Cancer statistics, 2005. CA Cancer J Clin. 2005 Jan-Feb; 55(1):10–30. doi: 10.3322/canjclin.55.1.10

22. Efanov M.G., Alikhanov R.B., Tsvirkun V.V., et al. . Short-term results of minimally invasive and open liver resections for colorectal cancer. Experience of a specialized center. Almanac of Clinical Medicine. 2018;46(6):584–591. (In Russ.). doi: 10.18786/2072-0505-2018-46-6-584-591

23. Efanov M.G., Granov D.A., Alikhanov R.B., et al. Survival after laparoscopic and open liver resections for colorectal cancer metastases. Comparative analysis using pseudo randomization. Annals of surgical hepatology. 2019;24(4):45–55. (In Russ.). doi: 10.16931/1995-5464.2019445-55

24. Emelyanov S.I., Alikhanov R.B., Panchenkov D.N., et al. The first experience of laparoscopic left-sided lateral bisegmentectomy for bilobar metastatic liver disease. Annals of surgical hepatology. 2007;4(12):45–47. (In Russ.).

25. Shabunin A.V., Parfenov I.P., Bedin V.V., et al. Comparison of parenchyma-sparing and extensive resections in the treatment of patients with colorectal cancer metastases to the liver. Bulletin of surgical gastroenterology. 2019;1:42–49. (In Russ.).

26. Aksel E.M., Barulina N.M. Colorectal cancer (incidence, mortality, socio-economic damage). Russian Journal of Oncology. 1999;6:40–46. (In Russ.).

27. Patyutko Yu.I. Surgical treatment of malignant liver tumors. Moscow: Practical Medicine. 2005; 312 p. (In Russ.).

28. Jin S, Fu Q, Wuyun G, et al. Management of posthepatectomy complications. World Journal of Gastroenterology. 2013;19(44):7983– 7991.

29. Adam R, de Gramont A, Figueras J, et al. Managing synchronous liver metastases from colorectal cancer: a multidisciplinary international consensus. Cancer Treat Rev. 2015;41(9):729–41. doi: 10.1016/j.ctrv.2015.06.006

30. Gong J, Gao F, Xie Q, et al. Open Resection Compared to MiniInvasive in Colorectal Cancer and Liver Metastases: A Meta-Analysis. Front Surg. 2021;30(8):726217. doi: 10.3389/fsurg.2021.726217

31. Gorchakov S.V., Pravosudov I.V., Vasiliev S.V. et al. Multidisciplinary approach to the treatment of patients with colorectal cancer with liver metastases — an oncologist’s view today. Volga Region Oncological Bulletin. 2015;4:70–8. (In Russ.).

32. Ponomarenko A. A., Achkasov S. I., Panina M. V., et al. . Impulsive operations for colorectal cancer with synchronous metastases in the liver. Koloproktologia. 2017; (4): 45-53. (In Russ.). doi: 10.33878/2073-7556-2017-0-4-45-53

33. Ono Y, Saiura A,Arita J, et al. Short-term outcomes after simultaneous colorectal and major hepatic resection for synchronous colorectal liver metastases. Dig Surg. 2017;34(6):447–454

34. Perfecto A, Gastaca M, Prieto M, et al. Totally laparoscopic simultaneous resection of colorectal cancer and synchronous liver metastases: a single-center case series. Surg Endosc. 36, 980–987 (2022).


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For citations:


Valiev A.A., Gataullin B.I., Zankina A.P., Gataullin I.G., Khasanov R.Sh., Valitov B.R. Early results of simultaneous laparoscopic operations for colorectal cancer with liver metastases. Koloproktologia. 2025;24(2):52-59. https://doi.org/10.33878/2073-7556-2025-24-2-52-59

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