Short course radiotherapy with consolidation chemotherapy for rectal cancer: a meta-analysis of randomized trials
https://doi.org/10.33878/2073-7556-2024-23-2-151-160
Abstract
AIM: to study the effect of total neoadjuvant therapy with consolidation chemotherapy for rectal cancer.
MATERIALS AND METHODS: the meta-analysis performed in accordance with PRISMA practices and guidelines.
RESULTS: short-course radiotherapy with consolidation chemotherapy compared to chemoradiotherapy (CRT) improves the rate of complete pathological responses (OR = 1.88; CI 1.47–2.42; p < 0.00001); does not affect the rate of local relapses (OR = 0.95; CI 0.72–1.24; p = 0.69), three-year disease-free survival (OR = 1.19; CI 0.99–1.44; p = 0.06) and overall survival (OR = 1.09; CI 0.88–1.35; p = 0.45). TNT increases the incidence of grade ≥ 3 toxicity (OR = 1.87; CI 1.10–3.18; p = 0.02), and does not affect treatment compliance (OR = 0.57; CI 0.17–1.95; p = 0.37).
CONCLUSION: the use of TNT can improve the oncological results of treatment of patients with rectal cancer by increasing the frequency of complete pathological responses.
About the Authors
R. I. Fayzulin
Ryzhikh National Medical Research Center of Coloproctology
Russian Federation
Russian Federation
Salyama Adilya st., 2, Moscow, 123423, Russia
M. V. Alekseev
Ryzhikh National Medical Research Center of Coloproctology;
Russian Medical Academy of Continuous Professional Education
Russian Federation
Russian Federation
Salyama Adilya st., 2, Moscow, 123423, Russia
Barrikadnaya st., 2/1-1, Moscow, 125993, Russia
E. G. Rybakov
Ryzhikh National Medical Research Center of Coloproctology
Russian Federation
Russian Federation
Salyama Adilya st., 2, Moscow, 123423, Russia
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For citations:
Fayzulin R.I., Alekseev M.V., Rybakov E.G. Short course radiotherapy with consolidation chemotherapy for rectal cancer: a meta-analysis of randomized trials. Koloproktologia. 2024;23(2):151-160. https://doi.org/10.33878/2073-7556-2024-23-2-151-160
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