Predictors of adverse outcomes of steroids in patients with severe ulcerative colitis (systematic review and meta-analyses)
https://doi.org/10.33878/2073-7556-2024-23-1-172-180
Abstract
AIM: to identify predictors of steroid resistance among patients with severe ulcerative colitis (UC).
PATIENTS AND METHODS: the systematic review and meta-analysis were done, 18 observational case-control studies and 2545 patients with severe UC were included.
RESULTS: the rate of patients with effective steroid therapy was 69.5%, and steroid resistance occurred in 30.5%. Pancolitis (OR = 1.5; 95% CI: 1.1–2) and endoscopic picture on the UCEIS ≥ 7 points (OR = 4.5; 95% CI: 3.2–6.5) were predictors of steroid resistance. The levels of albumin and C-reactive protein before the start and on the 3rd day of steroid treatment were also significantly corresponded with adverse outcome of the treatment (p < 0.00001). CONCLUSION: predictors of an adverse outcome are steroid resistance with pancolitis and endoscopic picture on the UCEIS scale ≥ 7 points. Hypoalbuminemia and high level of C-reactive protein were associated with the steroid resistance as well.
About the Authors
A. F. Mingazov
Ryzhikh National Medical Research Center of Coloproctology
Russian Federation
Russian Federation
Salyama Adilya st., 2, Moscow, 123423
O. I. Sushkov
Ryzhikh National Medical Research Center of Coloproctology
Russian Federation
Russian Federation
Salyama Adilya st., 2, Moscow, 123423
B. R. Kalanov
Ryzhikh National Medical Research Center of Coloproctology
Russian Federation
Russian Federation
Salyama Adilya st., 2, Moscow, 123423
T. A. Baranova
Ryzhikh National Medical Research Center of Coloproctology
Russian Federation
Russian Federation
Salyama Adilya st., 2, Moscow, 123423
S. I. Achkasov
Ryzhikh National Medical Research Center of Coloproctology; Russian Medical Academy of Continuous Professional Education
Russian Federation
Russian Federation
Salyama Adilya st., 2, Moscow, 123423
Barrikadnaya st., 2/1, Moscow, 125993
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Review
For citations:
Mingazov A.F., Sushkov O.I., Kalanov B.R., Baranova T.A., Achkasov S.I. Predictors of adverse outcomes of steroids in patients with severe ulcerative colitis (systematic review and meta-analyses). Koloproktologia. 2024;23(1):172-180. https://doi.org/10.33878/2073-7556-2024-23-1-172-180
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