Validation of the risk questionnaire for colorectal cancer detection
https://doi.org/10.33878/2073-7556-2023-22-3-76-84
Abstract
AIM: to develop and validate of the colorectal cancer screening questionnaire.
PATIENTS AND METHODS: six hundred ninety seven patients without any significant complaints were prospectively included in study. All patients underwent colonoscopy and specific questionnaire. Regression model was performed to stratificate significance level of definite questions.
RESULTS: colorectal cancer (CRC) was diagnosed in 39 (5.6%) patients, benign colon neoplasms — in 283 (40.6%) patients. In the ROC analysis, a cut-off of 23 points divides the group of patients into high and low risk of colorectal neoplasms with a sensitivity of 92.8% and a specificity of 39.2%. The area under the curve was 0.724, which corresponds to the good predictive value.
CONCLUSION: the developed questionnaire show good predictive power for high CRC risk patients identification, and can be included in the screening program model.
About the Authors
D. P. Kulovskaya
Ryzhih National Medical Research Center of Coloproctology
Russian Federation
Russian Federation
Salyama Adilya st., 2, Moscow, 123423
Yu. A. Shelygin
Ryzhih National Medical Research Center of Coloproctology; Russian Medical Academy of Continuous Professional Education
Russian Federation
Russian Federation
Salyama Adilya st., 2, Moscow, 123423
Barrikadnaya st., 2/1, Moscow, 125993
S. A. Frolov
Ryzhih National Medical Research Center of Coloproctology
Russian Federation
Russian Federation
Salyama Adilya st., 2, Moscow, 123423
S. I. Achkasov
Ryzhih National Medical Research Center of Coloproctology; Russian Medical Academy of Continuous Professional Education
Russian Federation
Russian Federation
Salyama Adilya st., 2, Moscow, 123423
Barrikadnaya st., 2/1, Moscow, 125993
References
1. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Canc J Clin. 2021; 71(3): 209-249. DOI: 10.3322/caac.21660.
2. Feng Y, Jin H, Guo K, et al. Causes of Death After Colorectal Cancer Diagnosis: A Population-Based Study. Front Oncol. 2021; Mar 30:11:647179. DOI: 10.3389/fonc.2021.647179.
3. Kaprin A.D., Starinsky V.V., Shakhzadova O.A. The state of oncological care for the population of Russia in 2021. Moscow: P.A. Herzen Moscow State Medical Research Institute branch of the Federal State Budgetary Institution “NMIRC” of the Ministry of Health of Russia; 2022, 239 р. (in Russ.).
4. Kaprin A.D., Starinsky V.V., Shakhzadova O.A. Malignant neoplasms in Russiain 2021 (morbidity and mortality). Moscow: P.A.Herzen Moscow State Medical Research Institute – Branch of the Federal State Budgetary Institution "NMIC of Radiology" of the Ministry of Health of Russia, 2022, 252 p. (In Russ.).
5. Hull MA, Rees CJ, Sharp L, et al. A risk-stratified approach to colorectal cancer prevention and diagnosis. Nat Rev Gastroenterol Hepatol. 2020; 17: 773–780. DOI: 10.1038/s41575-020-00368-3.
6. Siegel RL, Miller KD, Jemal A. Cancer statistics. CA: a cancer journal for clinicians. 2019;69:7-34.
7. Issa IA, Noureddine M. Colorectal cancer screening: An updated review of the available options. World Journal of Gastroenterology. 2018; 23(28): 5086–5096. DOI:10.3748/wjg.v23.i28.5086
8. Rex DK, Boland R, Dominitz JA, et al. Colorectal cancer screening: recommendations for physicians and patients from the U.S. multi-society task force on colorectal cancer. Am J Gastroenterol. 2017;30: 112:1016.DOI: 10.1038/ajg.2017.174.
9. Quintero E, Castells A, Bujanda L. Colonoscopy versus Fecal Immunochemical Testing in Colorectal-Cancer Screening. New England Journal of Medicine. 2012; 366(8): 697–706. DOI:10.1056/nejmoa1108895
10. Wu W, Huang J, Yang Y, et al. Adherence to colonoscopy in cascade screening of colorectal cancer: A systematic review and meta-analysis. J Gastroenterol Hepatol. 2022; Apr;37(4):620-631. DOI: 10.1111/jgh.15762
11. Bertels L, Lucassen P, van Asselt K, et al. Motives for non-adherence to colonoscopy advice after a positive colorectal cancer screening test result: a qualitative study. Scand J Prim Health Care. 2020 Dec; 38(4):487-498. DOI: 10.1080/02813432.2020.1844391
12. Corley DA, Jensen CD, Marks AR, et al. Adenoma Detection Rate and Risk of Colorectal Cancer and Death. New England Journal of Medicine. 2014; 370(14): 1298–1306. DOI:10.1056/nejmoa1309086.
13. Saw KS, Liu C, Xu W, et al. Faecal immunochemical test to triage patients with possible colorectal cancer symptoms: meta-analysis. Br J Surg. 2022 Feb 1;109(2):182-190. DOI: 10.1093/bjs/znab411
14. Benton SC, Piggott C, Blyuss O, et al. Impact of changing from a guaiac faecal occult blood test to a faecal immunochemical test in a national screening programme: Results from a pilot study within the national bowel cancer screening programme in England. J Med Screen. 2021 Dec;28(4):426-432. DOI: 10.1177/09691413211013376.
15. Ladabaum, Ur, Dominitz JA, Kahi Ch, et al. Strategies for Colorectal Cancer Screening. Gastroenterology. 2020 Jan;158(2):418-432. DOI: 10.1053/j.gastro.2019.06.043
16. Hoffman RM, Steel S, Yee EF, et al. Colorectal cancer screening adherence is higher with fecal immunochemical tests than guaiac-based fecal occult blood tests: a randomized, controlled trial. Prev Med. 2010 May-Jun;50(5-6):297-9. DOI: 10.1016/j.ypmed.2010.03.010
17. Kulovskaya D.P., Achkasov S.I., Shelygin Yu.A., et al. Comparative assessment of questionnaire and fecal immunochemical test efficacy in colorectal cancer screening. Surgeon. 2022;4. (in Russ.). DOI:10.33920/med-15-2204-04.
18. Finlay A; Macrae RMG, Seres D, et al. Colorectal Cancer: Epidemiology, Risk Factors, and Protective Factors. Available online: https://www.uptodate.com/contents/colorectal-cancer-epidemiologyrisk-factors-and-protective-factors (accessed on 24 December 2018).
19. Mauri G, Sartore-Bianchi A, Russo AG, et al. Early-onset colorectal cancer in young individuals. Mol Oncol. 2019;13:109–31. DOI: 10.1002/1878-0261.12417
Review
For citations:
Kulovskaya D.P., Shelygin Yu.A., Frolov S.A., Achkasov S.I. Validation of the risk questionnaire for colorectal cancer detection. Koloproktologia. 2023;22(3):76-84. https://doi.org/10.33878/2073-7556-2023-22-3-76-84
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