Colorectal cancer: epidemiology, carcinogenesis, molecular subtypes and cellular mechanisms of therapy resistance (analytical review)
https://doi.org/10.33878/2073-7556-2023-22-2-160-171
Abstract
This article analyzes the statistical data on colorectal cancer in Russia and in the world, including incidence, mortality and survival. The main pathways of colorectal cancer carcinogenesis, molecular subtypes and their influence on the difference in lesions of the proximal and distal large intestine are presented. The paper provides an overview of the leading chemotherapy agents and targeted therapy in colorectal cancer, as well as the main reasons for the development of therapeutic resistance, including changes in the cellular microenvironment of the tumor.
About the Authors
P. E. Maksimova
The Institute «Medical Academy named after S.I. Georgievsky» V.I. Vernadsky Crimean Federal University
Russian Federation
Russian Federation
Рolina E. Maksimova — sixth year student
Lenin blv, 5/7, Crimean Republic, Simferopol, 295051, Russia
E. P. Golubinskaya
The Institute «Medical Academy named after S.I. Georgievsky» V.I. Vernadsky Crimean Federal University
Russian Federation
Russian Federation
Elena P. Golubinskaya — Dr.Med.Sci., Leading Researcher
Lenin blv, 5/7, Crimean Republic, Simferopol, 295051, Russia
B. D. Seferov
OOO«Center of Clinical Oncology and Hematology»
Russian Federation
Russian Federation
Bekir D. Seferov — Cand.Med.Sci., Assistant of the Department of Oncology
Lenin blv, 5/7, Crimean Republic, Simferopol,295051, Russia
E. Yu. Zyablitskaya
The Institute «Medical Academy named after S.I. Georgievsky» V.I. Vernadsky Crimean Federal University
Russian Federation
Russian Federation
Evgenia Yu. Zyablitskaya — Dr.Med.Sci., Leading Researcher
Lenin blv, 5/7, Crimean Republic, Simferopol, 295051, Russia
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For citations:
Maksimova P.E., Golubinskaya E.P., Seferov B.D., Zyablitskaya E.Yu. Colorectal cancer: epidemiology, carcinogenesis, molecular subtypes and cellular mechanisms of therapy resistance (analytical review). Koloproktologia. 2023;22(2):160-171. https://doi.org/10.33878/2073-7556-2023-22-2-160-171
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