gnckКолопроктологияKoloproktologia2073-75562686-7303Russian Association of Coloproctology10.33878/2073-7556-2016-0-3-84-90gnck-40Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWАНЕМИИ ПРИ ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЯХ КИШЕЧНИКА (обзор литературы)ANEMIA OF INFLAMMATORY BOWEL DISEASE (review)СадыговаГ. Г.SadigovaG. H.doctorabu@mail.ruАзербайджанский Государственный Институт усовершенствования врачей им. А.АлиеваРоссияAzerbaijan State Advanced Training Institute for Doctors after A. ALIYEVRussian Federation201630092016038490Copyright © Садыгова Г.Г., 20162016Садыгова Г.Г.Sadigova G.H.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.ruproctology.com/jour/article/view/40воспалительные заболевания кишечникаанемияболезнь Кронаязвенный колитIBDanemiaulcerative colitisChron's diseasReferencesАнемия при воспалительных заболеваниях кишечника. В кн. Анемия - скрытая эпидемия / Пер. с англ. М.: МегаПро, 2004. - с. 57-59.Анемия при воспалительных заболеваниях кишечника. В кн. Анемия - скрытая эпидемия / Пер. с англ. М.: МегаПро, 2004. - с. 57-59.Козловская Л.В., Рамеев В.В. и соавт. Патогенез и клиническое значение анемии хронических заболеваний. Анемия. - 2005. - № 4. - с. 4-10.Козловская Л.В., Рамеев В.В. и соавт. Патогенез и клиническое значение анемии хронических заболеваний. Анемия. - 2005. - № 4. - с. 4-10.American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies. Practice guidelines for perioperative blood transfusion and adjuvant therapies: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies. Anesthesiology. - 2006. -105: 198-208.American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies. Practice guidelines for perioperative blood transfusion and adjuvant therapies: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies. Anesthesiology. - 2006. -105: 198-208.Andrews J.M., Travis S.P., Gibson P.R. et al. Systematic review: does concurrent therapy with 5-ASA and immunomodulators in inflammatory bowel disease improve outcomes? Aliment. Pharmacol. Ther. - 2009; 29: 459-69.Andrews J.M., Travis S.P., Gibson P.R. et al. Systematic review: does concurrent therapy with 5-ASA and immunomodulators in inflammatory bowel disease improve outcomes? Aliment. Pharmacol. Ther. - 2009; 29: 459-69.Andrews N.C. Anemia of inflammation: the cytokine-hepcidin link. J. Clin. Invest. - 2004; 113: 1251-1253.Andrews N.C. Anemia of inflammation: the cytokine-hepcidin link. J. Clin. Invest. - 2004; 113: 1251-1253.Bergamaschi G., Di Sabatino A., Albertini R. et al. Prevalence and pathogenesis of anemia in inflammatory bowel disease. Influence of anti-tumor necrosis factor-alpha treatment. Haematologica. -2010; 95: 199-205.Bergamaschi G., Di Sabatino A., Albertini R. et al. Prevalence and pathogenesis of anemia in inflammatory bowel disease. Influence of anti-tumor necrosis factor-alpha treatment. Haematologica. -2010; 95: 199-205.Bodemar G., Kechagias S., Almer S. et al. Treatment of anemia in inflammatory bowel disease with iron sucrose. Scand. J. Gastroenterol. - 2004; 39: 454-8.Bodemar G., Kechagias S., Almer S. et al. Treatment of anemia in inflammatory bowel disease with iron sucrose. Scand. J. Gastroenterol. - 2004; 39: 454-8.Bregman D.B., Morris D., Koch T.A. et al. Hepcidin levels predict nonresponsiveness to oral iron therapy in patients with iron deficiency anemia. Am. J. Hematol. - 2013; 88: 97-101.Bregman D.B., Morris D., Koch T.A. et al. Hepcidin levels predict nonresponsiveness to oral iron therapy in patients with iron deficiency anemia. Am. J. Hematol. - 2013; 88: 97-101.Colombel J.F., Ferrari N., Debuysere H. et al. Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn’s disease and severe myelosuppression during azathioprine therapy. Gastroenterology. - 2000; 118: 1025-30.Colombel J.F., Ferrari N., Debuysere H. et al. Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn’s disease and severe myelosuppression during azathioprine therapy. Gastroenterology. - 2000; 118: 1025-30.Cronin C.C., Shanahan F. Anemia in patients with chronic inflammatory bowel disease. Am. J. Gastroenterol. - 2001; 96: 2296-8.Cronin C.C., Shanahan F. Anemia in patients with chronic inflammatory bowel disease. Am. J. Gastroenterol. - 2001; 96: 2296-8.De Silva A.D., Tsironi E., Feakins R.M. et al. Efficacy and tolerability of oral iron therapy in inflammatory bowel disease: a prospective, comparative trial. Aliment. Pharmacol. Ther. - 2005; 22: 1097-105.De Silva A.D., Tsironi E., Feakins R.M. et al. Efficacy and tolerability of oral iron therapy in inflammatory bowel disease: a prospective, comparative trial. Aliment. Pharmacol. Ther. - 2005; 22: 1097-105.Domenech E., Manosa M., Masnou H. et al. Infliximab for the treatment of chronic anemia in Crohn’s disease. Am. J. Gastroenterol. - 2005; 100: 496.Domenech E., Manosa M., Masnou H. et al. Infliximab for the treatment of chronic anemia in Crohn’s disease. Am. J. Gastroenterol. - 2005; 100: 496.Duerksen D.R., Fallows G., Bernstein C.N. Vitamin B12 malabsorption in patients with limited ileal resection. Nutrition. - 2006; 22: 1210-3.Duerksen D.R., Fallows G., Bernstein C.N. Vitamin B12 malabsorption in patients with limited ileal resection. Nutrition. - 2006; 22: 1210-3.Erichsen K., Ulvik R.J., Nysaeter G. et al. Oral ferrous fumarate or intravenous iron sucrose for patients with inflammatory bowel disease. Scand. J. Gastroenterol. - 2005; 40: 1058-65.Erichsen K., Ulvik R.J., Nysaeter G. et al. Oral ferrous fumarate or intravenous iron sucrose for patients with inflammatory bowel disease. Scand. J. Gastroenterol. - 2005; 40: 1058-65.European Consensus on the Diagnosis and Management of Iron Deficiency and Anaemia in Inflammatory Bowel Diseases. Journal of Crohn’s and Colitis. - 2015. - v. 9, Issue 3. - p. 211-222.European Consensus on the Diagnosis and Management of Iron Deficiency and Anaemia in Inflammatory Bowel Diseases. Journal of Crohn’s and Colitis. - 2015. - v. 9, Issue 3. - p. 211-222.Evstatiev R., Alexeeva O., Bokemeyer B. et al. Ferric carboxymaltose prevents recurrence of anemia in patients with inflammatory bowel disease. Clin. Gastroenterol. Hepatol. - 2013; 11: 269-77.Evstatiev R., Alexeeva O., Bokemeyer B. et al. Ferric carboxymaltose prevents recurrence of anemia in patients with inflammatory bowel disease. Clin. Gastroenterol. Hepatol. - 2013; 11: 269-77.Evstatiev R., Gasche C. Iron sensing and signalling. Gut. - 2012; 61: 933-52.Evstatiev R., Gasche C. Iron sensing and signalling. Gut. - 2012; 61: 933-52.Evstatiev R., Marteau P., Iqbal T. et al. FERGIcor, a randomized controlled trial on ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease. Gastroenterology. - 2011; 141: 846-53, e841-42.Evstatiev R., Marteau P., Iqbal T. et al. FERGIcor, a randomized controlled trial on ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease. Gastroenterology. - 2011; 141: 846-53, e841-42.Favrat B., Balck K., Breymann C. et al. Evaluation of a single dose of ferric carboxymaltose in fatigued, iron-deficient women - PREFER, a randomized, placebo-controlled study. PLoS One. - 2014; 9: e94217.Favrat B., Balck K., Breymann C. et al. Evaluation of a single dose of ferric carboxymaltose in fatigued, iron-deficient women - PREFER, a randomized, placebo-controlled study. PLoS One. - 2014; 9: e94217.Ford D., Cohen M., Strauss W. et al. Evaluation of ferumoxytol treatment for iron deficiency anemia in patients with gastrointestinal disorders who have a history of unsatisfactory oral iron therapy: results of a Phase III, randomized, placebo-controlled trial. Gastroenterology. - 2013; 144: S754.Ford D., Cohen M., Strauss W. et al. Evaluation of ferumoxytol treatment for iron deficiency anemia in patients with gastrointestinal disorders who have a history of unsatisfactory oral iron therapy: results of a Phase III, randomized, placebo-controlled trial. Gastroenterology. - 2013; 144: S754.Hepcidin G.T. A key regulator of iron metabolism and mediator of anemia of inflammation. Blood. -2003; 102: 783-788.Hepcidin G.T. A key regulator of iron metabolism and mediator of anemia of inflammation. Blood. -2003; 102: 783-788.Garcia-Erce J.A., Gomollon F., Munoz M. Blood transfusion for the treatment of acute anemia in inflammatory bowel disease and other digestive diseases. World J. Gastroenterol. - 2009; 15: 4686-94.Garcia-Erce J.A., Gomollon F., Munoz M. Blood transfusion for the treatment of acute anemia in inflammatory bowel disease and other digestive diseases. World J. Gastroenterol. - 2009; 15: 4686-94.Gasche C., Berstad A., Befrits R. et al. Guidelines on the diagnosis and management of iron deficiency and anemia in inflammatory bowel diseases. Inflamm. Bowel Dis. - 2007; 13: 1545-53.Gasche C., Berstad A., Befrits R. et al. Guidelines on the diagnosis and management of iron deficiency and anemia in inflammatory bowel diseases. Inflamm. Bowel Dis. - 2007; 13: 1545-53.Gasche C., Lomer M.C., Cavill I. et al. Iron, anemia, and inflammatory bowel diseases. Gut. -2004; 53: 1190-7.Gasche C., Lomer M.C., Cavill I. et al. Iron, anemia, and inflammatory bowel diseases. Gut. -2004; 53: 1190-7.Gasche C. Anemia in IBD: the overlooked villain. Inflamm Bowel Dis. - 2000; 6: 142-50.Gasche C. Anemia in IBD: the overlooked villain. Inflamm Bowel Dis. - 2000; 6: 142-50.Gasche C. Anemia in Inflammatory Bowel Disease. Bremen, Germany: Unimed. - 2008.Gasche C. Anemia in Inflammatory Bowel Disease. Bremen, Germany: Unimed. - 2008.Gasche C., Kulnigg S. Intravenosus Iron in Inflammatory Bowel Disease. Seminars in Hematology. 2006. - v. 43. - № 4. - Suppl 6, S18-S22.Gasche C., Kulnigg S. Intravenosus Iron in Inflammatory Bowel Disease. Seminars in Hematology. 2006. - v. 43. - № 4. - Suppl 6, S18-S22.Gisbert J.P., Gomollon F. Common misconceptions in the diagnosis and management of anemia in inflammatory bowel disease. Am. J. Gastroenterol. -2008; 103: 1299-307.Gisbert J.P., Gomollon F. Common misconceptions in the diagnosis and management of anemia in inflammatory bowel disease. Am. J. Gastroenterol. -2008; 103: 1299-307.Gomollon F., Gisbert J.P. Anemia and inflammatory bowel diseases. World J. Gastroenterol. -2009; 15: 4659-65.Gomollon F., Gisbert J.P. Anemia and inflammatory bowel diseases. World J. Gastroenterol. -2009; 15: 4659-65.Goodhand J.R., Kamperidis N., Rao A. et al. Prevalence and management of anemia in children, adolescents, and adults with inflammatory bowel disease. Inflamm. Bowel Dis. - 2012; 18: 513-9.Goodhand J.R., Kamperidis N., Rao A. et al. Prevalence and management of anemia in children, adolescents, and adults with inflammatory bowel disease. Inflamm. Bowel Dis. - 2012; 18: 513-9.Green R. Indicators for assessing folate and vitamin B-12 status and for monitoring the efficacy of intervention strategies. Am. J. Clin. Nutr. -2011; 94: 666S-672S.Green R. Indicators for assessing folate and vitamin B-12 status and for monitoring the efficacy of intervention strategies. Am. J. Clin. Nutr. -2011; 94: 666S-672S.Hochman J.A. Autoimmune hemolytic anemia associated with Crohn’s disease. Inflamm. Bowel Dis. - 2002; 8: 98-100.Hochman J.A. Autoimmune hemolytic anemia associated with Crohn’s disease. Inflamm. Bowel Dis. - 2002; 8: 98-100.Kallel L., Boubaker J., Filali A. Autoimmune hemolytic anemia in a young adult with Crohn’s disease and primary sclerosing cholangitis: an unusual association. J. Crohns Colitis. - 2009; 3: 134-5.Kallel L., Boubaker J., Filali A. Autoimmune hemolytic anemia in a young adult with Crohn’s disease and primary sclerosing cholangitis: an unusual association. J. Crohns Colitis. - 2009; 3: 134-5.Khalil A., Goodhand J.R., Wahed M. et al. Efficacy and tolerability of intravenous iron dextran and oral iron in inflammatory bowel disease: a case-matched study in clinical practice. Eur J. Gastroenterol. Hepatol. - 2011; 23: 1029-35.Khalil A., Goodhand J.R., Wahed M. et al. Efficacy and tolerability of intravenous iron dextran and oral iron in inflammatory bowel disease: a case-matched study in clinical practice. Eur J. Gastroenterol. Hepatol. - 2011; 23: 1029-35.Kishikawa H., Nishida J., Nakano M. et al. Ulcerative colitis associated with aplastic anemia. Dig. Dis. Sci. - 2003; 48: 1376-9.Kishikawa H., Nishida J., Nakano M. et al. Ulcerative colitis associated with aplastic anemia. Dig. Dis. Sci. - 2003; 48: 1376-9.Koutroubakis I.E., Karmiris K., Makreas S. et al. Effectiveness of darbepoetin-alfa in combination with intravenous iron sucrose in patients with inflammatory bowel disease and refractory anemia: a pilot study. Eur. J. Gastroenterol. Hepatol. - 2006; 18: 421-5.Koutroubakis I.E., Karmiris K., Makreas S. et al. Effectiveness of darbepoetin-alfa in combination with intravenous iron sucrose in patients with inflammatory bowel disease and refractory anemia: a pilot study. Eur. J. Gastroenterol. Hepatol. - 2006; 18: 421-5.Koutroubakis I.E., Oustamanolakis P., Karakoidas C. et al. Safety and efficacy of total-dose infusion of low molecular weight iron dextran for iron deficiency anemia in patients with inflammatory bowel disease. Dig. Dis. Sci. - 2010; 55: 2327-31.Koutroubakis I.E., Oustamanolakis P., Karakoidas C. et al. Safety and efficacy of total-dose infusion of low molecular weight iron dextran for iron deficiency anemia in patients with inflammatory bowel disease. Dig. Dis. Sci. - 2010; 55: 2327-31.Kulnigg S., Gasche C. Systematic review: managing anemia in Crohn’s disease. Aliment. Pharmacol. Ther. - 2006; 24: 1507-23.Kulnigg S., Gasche C. Systematic review: managing anemia in Crohn’s disease. Aliment. Pharmacol. Ther. - 2006; 24: 1507-23.Kulnigg S., Stoinov S., Simanenkov V. et al. A novel intravenous iron formulation for treatment of anemia in inflammatory bowel disease: the ferric carboxymaltose [FERINJECT] randomized controlled trial. Am. J. Gastroenterol. - 2008; 103: 1182-92.Kulnigg S., Stoinov S., Simanenkov V. et al. A novel intravenous iron formulation for treatment of anemia in inflammatory bowel disease: the ferric carboxymaltose [FERINJECT] randomized controlled trial. Am. J. Gastroenterol. - 2008; 103: 1182-92.Lennard L. TPMT in the treatment of Crohn’s disease with azathioprine. Gut. - 2002; 51: 143-6.Lennard L. TPMT in the treatment of Crohn’s disease with azathioprine. Gut. - 2002; 51: 143-6.Leo Carnerero E., Aoufi S., Montero Cuadrado I. et al. Autoimmune hemolytic anemia associated with ulcerative colitis: response to infliximab. Am. J. Gastroenterol. - 2009; 104: 2370-1.Leo Carnerero E., Aoufi S., Montero Cuadrado I. et al. Autoimmune hemolytic anemia associated with ulcerative colitis: response to infliximab. Am. J. Gastroenterol. - 2009; 104: 2370-1.Lindgren S., Wikman O., Befrits R. et al. Intravenous iron sucrose is superior to oral iron sulphate for correcting anemia and restoring iron stores in IBD patients: a randomized, controlled, evaluator-blind, multicentre study. Scand. J. Gastroenterol. - 2009; 44: 838-45.Lindgren S., Wikman O., Befrits R. et al. Intravenous iron sucrose is superior to oral iron sulphate for correcting anemia and restoring iron stores in IBD patients: a randomized, controlled, evaluator-blind, multicentre study. Scand. J. Gastroenterol. - 2009; 44: 838-45.Lyseng-Williamson K.A., Keating G.M. Ferric carboxymaltose: a review of its use in iron-deficiency anemia. Drugs. - 2009; 69: 739-56.Lyseng-Williamson K.A., Keating G.M. Ferric carboxymaltose: a review of its use in iron-deficiency anemia. Drugs. - 2009; 69: 739-56.Molnar T., Farkas K., Szepes Z. et al. Autoimmune hemolytic anemia associated with ulcerative colitis: the most important step is to induce complete remission. Am. J. Gastroenterol. - 2010; 105: 1203-4.Molnar T., Farkas K., Szepes Z. et al. Autoimmune hemolytic anemia associated with ulcerative colitis: the most important step is to induce complete remission. Am. J. Gastroenterol. - 2010; 105: 1203-4.Naithani R., Mahapatra M., Kumar R. et al. Aplastic anemia and Crohn’s disease - coincidence or association? Indian J. Gastroenterol. - 2005; 24: 183.Naithani R., Mahapatra M., Kumar R. et al. Aplastic anemia and Crohn’s disease - coincidence or association? Indian J. Gastroenterol. - 2005; 24: 183.Oldenburg B., Koningsberger J.C., Berge Henegouwen G.P. et al. Iron and inflammatory bowel disease. Aliment Pharmacol. Ther. - 2001; 15: 429-38.Oldenburg B., Koningsberger J.C., Berge Henegouwen G.P. et al. Iron and inflammatory bowel disease. Aliment Pharmacol. Ther. - 2001; 15: 429-38.Onken J.E., Bregman D.B., Harrington R.A. et al. A multicenter, randomized, active-controlled study to investigate the efficacy and safety of intravenous ferric carboxymaltose in patients with iron deficiency anemia. Transfusion. - 2014; 54: 306-15.Onken J.E., Bregman D.B., Harrington R.A. et al. A multicenter, randomized, active-controlled study to investigate the efficacy and safety of intravenous ferric carboxymaltose in patients with iron deficiency anemia. Transfusion. - 2014; 54: 306-15.Oustamanolakis P., Koutroubakis I.E., Kouroumalis E.A. Diagnosing anemia in inflammatory bowel disease: beyond the established markers. J. Crohns Colitis. - 2011; 5: 381-91.Oustamanolakis P., Koutroubakis I.E., Kouroumalis E.A. Diagnosing anemia in inflammatory bowel disease: beyond the established markers. J. Crohns Colitis. - 2011; 5: 381-91.Oustamanolakis P., Koutroubakis I.E., Messaritakis I. et al. Measurement of reticulocyte and red blood cell indices in the evaluation of anemia in inflammatory bowel disease. J. Crohns Colitis. -2011; 5: 295-300.Oustamanolakis P., Koutroubakis I.E., Messaritakis I. et al. Measurement of reticulocyte and red blood cell indices in the evaluation of anemia in inflammatory bowel disease. J. Crohns Colitis. -2011; 5: 295-300.Reinisch W., Staun M., Tandon R.K. et al. A randomized, open-label, non-inferiority study of intravenous iron isomaltoside 1,000 [Monofer] compared with oral iron for treatment of anemia in IBD [PROCEED]. Am. J. Gastroenterol. -2013; 108: 1877-88.Reinisch W., Staun M., Tandon R.K. et al. A randomized, open-label, non-inferiority study of intravenous iron isomaltoside 1,000 [Monofer] compared with oral iron for treatment of anemia in IBD [PROCEED]. Am. J. Gastroenterol. -2013; 108: 1877-88.Schroder O., Mickisch O., Seidler U. et al. Intravenous iron sucrose versus oral iron supplementation for the treatment of iron deficiency anemia in patients with inflammatory bowel disease -a randomized, controlled, open-label, multicenter study. Am. J. Gastroenterol. - 2005; 100: 2503-9.Schroder O., Mickisch O., Seidler U. et al. Intravenous iron sucrose versus oral iron supplementation for the treatment of iron deficiency anemia in patients with inflammatory bowel disease -a randomized, controlled, open-label, multicenter study. Am. J. Gastroenterol. - 2005; 100: 2503-9.Semrin G., Fishman D.S., Bousvaros A. et al. Impaired intestinal iron absorption in Crohn’s disease correlates with disease activity and markers of inflammation. Inflamm. Bowel Dis. - 2006; 12: 1101-6.Semrin G., Fishman D.S., Bousvaros A. et al. Impaired intestinal iron absorption in Crohn’s disease correlates with disease activity and markers of inflammation. Inflamm. Bowel Dis. - 2006; 12: 1101-6.Skikne B.S., Punnonen K., Caldron P.H. et al. Improved differential diagnosis of anemia of chronic disease and iron deficiency anemia: a prospective multicenter evaluation of soluble transferrin receptor and the sTfR/log ferritin index. Am. J. Hematol. -2011; 86: 923-7.Skikne B.S., Punnonen K., Caldron P.H. et al. Improved differential diagnosis of anemia of chronic disease and iron deficiency anemia: a prospective multicenter evaluation of soluble transferrin receptor and the sTfR/log ferritin index. Am. J. Hematol. -2011; 86: 923-7.Stein J., Hartmann F., Dignass A.U. Diagnosis and management of iron deficiency anemia in patients with IBD. Nat. Rev. Gastroenterol. Hepatol. -2010; 7: 599-610.Stein J., Hartmann F., Dignass A.U. Diagnosis and management of iron deficiency anemia in patients with IBD. Nat. Rev. Gastroenterol. Hepatol. -2010; 7: 599-610.Tsiopoulos F.D., Manolakis A.C., Kapsoritakis A.N. et al. Autoimmune hemolytic anemia and ophthalmic artery thrombosis preceding the intestinal manifestations of Crohn’s disease. Inflamm. Bowel. Dis. -2009; 15: 487-8.Tsiopoulos F.D., Manolakis A.C., Kapsoritakis A.N. et al. Autoimmune hemolytic anemia and ophthalmic artery thrombosis preceding the intestinal manifestations of Crohn’s disease. Inflamm. Bowel. Dis. -2009; 15: 487-8.Villanueva C., Colomo A., Bosch A. et al. Transfusion strategies for acute upper gastrointestinal bleeding. N. Engl. J. Med. - 2013; 368: 11-21.Villanueva C., Colomo A., Bosch A. et al. Transfusion strategies for acute upper gastrointestinal bleeding. N. Engl. J. Med. - 2013; 368: 11-21.Weiss G., Gasche C. Pathogenesis and treatment of anemia in inflammatory bowel disease. Haematologica. - 2010; 95: 175-8.Weiss G., Gasche C. Pathogenesis and treatment of anemia in inflammatory bowel disease. Haematologica. - 2010; 95: 175-8.Weiss G., Goodnough L.T. Anemia of chronic disease. N. Engl. J. Med. - 2005; 352: 1011-23.Weiss G., Goodnough L.T. Anemia of chronic disease. N. Engl. J. Med. - 2005; 352: 1011-23.Werner T., Wagner S.J., Martinez I. et al. Depletion of luminal iron alters the gut microbiota and prevents Crohn’s disease-like ileitis. Gut. - 2011; 60: 325-33.Werner T., Wagner S.J., Martinez I. et al. Depletion of luminal iron alters the gut microbiota and prevents Crohn’s disease-like ileitis. Gut. - 2011; 60: 325-33.Wiesen A., Wiesen J., Limaye S. et al. Mesalazineinduced aplastic anemia. Am. J. Gastroenterol. -2009; 104: 1063.Wiesen A., Wiesen J., Limaye S. et al. Mesalazineinduced aplastic anemia. Am. J. Gastroenterol. -2009; 104: 1063.Wilson A., Reyes E., Ofman J. Prevalence and outcomes of anemia in inflammatory bowel disease: a systematic review of the literature. Am. J. Med. -2004; 116 Suppl 7A: 44S-9S.Wilson A., Reyes E., Ofman J. Prevalence and outcomes of anemia in inflammatory bowel disease: a systematic review of the literature. Am. J. Med. -2004; 116 Suppl 7A: 44S-9S.Wu C.H., Wong J.M., Hsieh S.C. An unusual case of ulcerative colitis with concurrent extraintestinal manifestations of primary sclerosing cholangitis, thromboembolism, hemolytic anemia, and hemochromatosis. J. Microbiol. Immunol. Infect. -2005; 38: 224-9.Wu C.H., Wong J.M., Hsieh S.C. An unusual case of ulcerative colitis with concurrent extraintestinal manifestations of primary sclerosing cholangitis, thromboembolism, hemolytic anemia, and hemochromatosis. J. Microbiol. Immunol. Infect. -2005; 38: 224-9.Yakut M., Ustun Y., Kabacam G. et al. Serum vitamin B12 and folate status in patients with inflammatory bowel diseases. Eur. J. Intern. Med. -2010; 21: 320-3.Yakut M., Ustun Y., Kabacam G. et al. Serum vitamin B12 and folate status in patients with inflammatory bowel diseases. Eur. J. Intern. Med. -2010; 21: 320-3.Yu L.Z., Qian S., Hong M. et al. A case of ulcerative colitis associated with autoimmune hemolytic anemia successfully treated by autologous hematopoietic stem cell transplantation. Am. J. Gastroenterol. -2010; 105: 2302-4.Yu L.Z., Qian S., Hong M. et al. A case of ulcerative colitis associated with autoimmune hemolytic anemia successfully treated by autologous hematopoietic stem cell transplantation. Am. J. Gastroenterol. -2010; 105: 2302-4.
The authors declare that there are no conflicts of interest present.