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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gnck</journal-id><journal-title-group><journal-title xml:lang="ru">Колопроктология</journal-title><trans-title-group xml:lang="en"><trans-title>Koloproktologia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-7556</issn><issn pub-type="epub">2686-7303</issn><publisher><publisher-name>Russian Association of Coloproctology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33878/2073-7556-2017-0-3-71-79</article-id><article-id custom-type="elpub" pub-id-type="custom">gnck-324</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>ЭФФЕКТИВНОСТЬ И БЕЗОПАСНОСТЬ ПРИМЕНЕНИЯ ВЕДОЛИЗУМАБА ПРИ БОЛЕЗНИ КРОНА (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>EFFICACY AND SAFETY OF VEDOLIZUMAB IN CROHN'S DISEASE (review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Харитонов</surname><given-names>Андрей Геннадьевич</given-names></name><name name-style="western" xml:lang="en"><surname>Kharitonov</surname><given-names>A. G.</given-names></name></name-alternatives><email xlink:type="simple">mldruz@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Северо-Западный государственный медицинский университет имени И.И.Мечникова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North-Western Medical State University named after I.I.Mechnikov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>30</day><month>09</month><year>2017</year></pub-date><volume>0</volume><issue>3</issue><fpage>71</fpage><lpage>79</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Харитонов А.Г., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Харитонов А.Г.</copyright-holder><copyright-holder xml:lang="en">Kharitonov A.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ruproctology.com/jour/article/view/324">https://www.ruproctology.com/jour/article/view/324</self-uri><kwd-group xml:lang="ru"><kwd>Болезнь Крона</kwd><kwd>воспалительные заболевания кишечника</kwd><kwd>ведолизумаб</kwd><kwd>моноклональные антитела к а4р7-интегрину</kwd><kwd>ингибиторы ФНО-а</kwd><kwd>безопасность</kwd><kwd>эффективность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Crohn's disease</kwd><kwd>inflammatory bowel disease</kwd><kwd>vedolizumab</kwd><kwd>anti-a4β7 integrin monoclonal antibody</kwd><kwd>safety</kwd><kwd>efficacy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Molodecky, N.A. 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