<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gnck</journal-id><journal-title-group><journal-title xml:lang="ru">Колопроктология</journal-title><trans-title-group xml:lang="en"><trans-title>Koloproktologia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-7556</issn><issn pub-type="epub">2686-7303</issn><publisher><publisher-name>Russian Association of Coloproctology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33878/2073-7556-2017-0-3-63-70</article-id><article-id custom-type="elpub" pub-id-type="custom">gnck-323</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>ПРОТИВОРЕЦИДИВНАЯ ТЕРАПИЯ БОЛЕЗНИ КРОНА В ПОСЛЕОПЕРАЦИОННОМ ПЕРИОДЕ (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>POSTOPERATIVE PREVENTIVE TREATMENT OF CROHN'S DISEASE (review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Халиф</surname><given-names>И. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Khalif</surname><given-names>I. L.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Варданян</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vardanyan</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шапина</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shapina</surname><given-names>M. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Полетова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Poletova</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">poletova35@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «ГНЦК им. А.Н.Рыжих» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Scientific Centre of Coloproctology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>30</day><month>09</month><year>2017</year></pub-date><volume>0</volume><issue>3</issue><fpage>63</fpage><lpage>70</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Халиф И.Л., Варданян А.В., Шапина М.В., Полетова А.В., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Халиф И.Л., Варданян А.В., Шапина М.В., Полетова А.В.</copyright-holder><copyright-holder xml:lang="en">Khalif I.L., Vardanyan A.V., Shapina M.V., Poletova A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ruproctology.com/jour/article/view/323">https://www.ruproctology.com/jour/article/view/323</self-uri><kwd-group xml:lang="ru"><kwd>болезнь Крона</kwd><kwd>рецидив</kwd><kwd>терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Crohn's disease</kwd><kwd>recurrence</kwd><kwd>treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Воробьев, Г.И. Неспецифические воспалительные заболевания кишечника / Г.И.Воробьев, И.Л.Халиф // М.: Миклош, 2008. - с. 248-251.</mixed-citation><mixed-citation xml:lang="en">Воробьев, Г.И. Неспецифические воспалительные заболевания кишечника / Г.И.Воробьев, И.Л.Халиф // М.: Миклош, 2008. - с. 248-251.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Головенко, А.О. Профилактика послеоперационных рецидивов болезни Крона. / A.О.Головенко, И.Л.Халиф, О.В.Головенко и соавт. // Колопроктология. - 2012. - 4 (42). - с. 40-48.</mixed-citation><mixed-citation xml:lang="en">Головенко, А.О. Профилактика послеоперационных рецидивов болезни Крона. / A.О.Головенко, И.Л.Халиф, О.В.Головенко и соавт. // Колопроктология. - 2012. - 4 (42). - с. 40-48.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Голышева, С.В. Качество жизни больных неспецифическим язвенным колитом и болезнью Крона до и после операции. / С.В.Голышева // Автореферат дис.. канд. мед. наук. - Москва: Первый МГМУ им. Сеченова, 2007. - с. 24.</mixed-citation><mixed-citation xml:lang="en">Голышева, С.В. Качество жизни больных неспецифическим язвенным колитом и болезнью Крона до и после операции. / С.В.Голышева // Автореферат дис.. канд. мед. наук. - Москва: Первый МГМУ им. Сеченова, 2007. - с. 24.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Репетий, Н.Г. Язвенный колит и болезнь Крона: о выборе решения к переходу от консервативного лечения к хирургическому / Н.Г.Репетий, B.Б.Александров, О.Ю.Рахимова // Медицинский Вестник МВД. - 2010. - 4 (47). - с. 12-15.</mixed-citation><mixed-citation xml:lang="en">Репетий, Н.Г. Язвенный колит и болезнь Крона: о выборе решения к переходу от консервативного лечения к хирургическому / Н.Г.Репетий, B.Б.Александров, О.Ю.Рахимова // Медицинский Вестник МВД. - 2010. - 4 (47). - с. 12-15.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Agrez, M.V. et al. Surgical history of Crohn’s disease in a well-defined population. / M.V.Agrez. // Mayo Clin Proc. - 1982. - 57 (12). - р. 747-752.</mixed-citation><mixed-citation xml:lang="en">Agrez, M.V. et al. Surgical history of Crohn’s disease in a well-defined population. / M.V.Agrez. // Mayo Clin Proc. - 1982. - 57 (12). - р. 747-752.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Aguas, M. Adalimumab in prevention of postoperative recurrence of Crohn’s disease in high-risk patients. / M.Aguas, G.Bastida, E.Cerrillo, et al. // World J. Gastroenterol. - 2012. - 18 (32). - р. 43914398.</mixed-citation><mixed-citation xml:lang="en">Aguas, M. Adalimumab in prevention of postoperative recurrence of Crohn’s disease in high-risk patients. / M.Aguas, G.Bastida, E.Cerrillo, et al. // World J. Gastroenterol. - 2012. - 18 (32). - р. 43914398.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Araki, T. The impact of postoperative infliximab maintenance therapy on preventing the surgical recurrence of Crohn’s disease: a single-center paired case-control study. / T.Araki, K.Uchida, Y.Okita, et al. // Surg. Today. - 2014. - 44 (2). - р. 291-296.</mixed-citation><mixed-citation xml:lang="en">Araki, T. The impact of postoperative infliximab maintenance therapy on preventing the surgical recurrence of Crohn’s disease: a single-center paired case-control study. / T.Araki, K.Uchida, Y.Okita, et al. // Surg. Today. - 2014. - 44 (2). - р. 291-296.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ardizzone, S. Azathioprine and mesalamine for prevention of relapse after conservative surgery for Crohn’s disease. / S.Ardizzone, G.Maconi, G.M.Sampietro et al. // Gastroenterology. - 2004. -127. - р. 730-740.</mixed-citation><mixed-citation xml:lang="en">Ardizzone, S. Azathioprine and mesalamine for prevention of relapse after conservative surgery for Crohn’s disease. / S.Ardizzone, G.Maconi, G.M.Sampietro et al. // Gastroenterology. - 2004. -127. - р. 730-740.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Armuzzi, A. Prevention of postoperative recurrence with azathioprine or infliximab in patients with Crohn’s disease: an open-label pilot study. / M.Regueiro, K.E.Kip, L.Baidoo et al. // J. Crohns Colitis. - 2013. -7 (12). - р. 623-629.</mixed-citation><mixed-citation xml:lang="en">Armuzzi, A. Prevention of postoperative recurrence with azathioprine or infliximab in patients with Crohn’s disease: an open-label pilot study. / M.Regueiro, K.E.Kip, L.Baidoo et al. // J. Crohns Colitis. - 2013. -7 (12). - р. 623-629.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Bernell, O. Risk factors for surgery and postoperative recurrence in Crohn’s disease. / O.Bernell, A.Lapidus, G.Hellers. // Ann. Surg. -2000. - 231. - р. 38-45.</mixed-citation><mixed-citation xml:lang="en">Bernell, O. Risk factors for surgery and postoperative recurrence in Crohn’s disease. / O.Bernell, A.Lapidus, G.Hellers. // Ann. Surg. -2000. - 231. - р. 38-45.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Bernell, O. Risk factors for surgery and recurrence in 907 patients with primary ileocaecalCrohn’s disease. / O.Bernell, A.Lapidus, G.Hellers // Br. J. Surg. - 2000. - 87 (12). - р. 1697-701.</mixed-citation><mixed-citation xml:lang="en">Bernell, O. Risk factors for surgery and recurrence in 907 patients with primary ileocaecalCrohn’s disease. / O.Bernell, A.Lapidus, G.Hellers // Br. J. Surg. - 2000. - 87 (12). - р. 1697-701.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">D’Haens, GR. Early lesions of recurrent Crohn’s disease caused by infusion of intestinal contents in excluded ileum. / G.R.D’Haens, K.Geboes, M.Peeters et al. // Gastroenterology. - 1998. - 114. - p. 262-267.</mixed-citation><mixed-citation xml:lang="en">D’Haens, GR. Early lesions of recurrent Crohn’s disease caused by infusion of intestinal contents in excluded ileum. / G.R.D’Haens, K.Geboes, M.Peeters et al. // Gastroenterology. - 1998. - 114. - p. 262-267.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">De Cruz, P. Crohn’s disease management after intestinal resection: a randomised trial. / P.De Cruz, M.A.Kamm, A.L.Hamilton et al. // Lancet. - 2015. -385 (9976). - Р. 1406-1417.</mixed-citation><mixed-citation xml:lang="en">De Cruz, P. Crohn’s disease management after intestinal resection: a randomised trial. / P.De Cruz, M.A.Kamm, A.L.Hamilton et al. // Lancet. - 2015. -385 (9976). - Р. 1406-1417.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Doherty, G. Interventions for prevention of postoperative recurrence of Crohn’s disease. / G.Doherty, G.Bennett, S.Patil et al. // Cochrane Database Syst Rev. - 2009: - 10.1002/14651858.CD006873.pub2.</mixed-citation><mixed-citation xml:lang="en">Doherty, G. Interventions for prevention of postoperative recurrence of Crohn’s disease. / G.Doherty, G.Bennett, S.Patil et al. // Cochrane Database Syst Rev. - 2009: - 10.1002/14651858.CD006873.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Ewe, K. Postoperative recurrence of Crohn’s disease in relation to radicality of operation and sulfasalazine prophylaxis: a multicenter trial. / K.Ewe, C.Herfarth, H.Malchow et al. // Digestion. - 1989. - 42. - p. 224-232.</mixed-citation><mixed-citation xml:lang="en">Ewe, K. Postoperative recurrence of Crohn’s disease in relation to radicality of operation and sulfasalazine prophylaxis: a multicenter trial. / K.Ewe, C.Herfarth, H.Malchow et al. // Digestion. - 1989. - 42. - p. 224-232.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ford, A.C. 5-aminosalicylates prevent relapse of Crohn’s disease after surgically induced remission: systematic review and meta-analysis. / A.C.Ford, K.J.Khan, N.J.Talley et al. // Am. J. Gastroenterol. - 2011. - 106 (3). - p. 413-420.</mixed-citation><mixed-citation xml:lang="en">Ford, A.C. 5-aminosalicylates prevent relapse of Crohn’s disease after surgically induced remission: systematic review and meta-analysis. / A.C.Ford, K.J.Khan, N.J.Talley et al. // Am. J. Gastroenterol. - 2011. - 106 (3). - p. 413-420.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Greenstein, A.J. Perforating and nonperforating indications for repeated operations in Crohn’s disease: evidence for two clinical forms. / A.J.Greenstein et al. // Gut. - 1988. - 29 (5). - p. 588-592.</mixed-citation><mixed-citation xml:lang="en">Greenstein, A.J. Perforating and nonperforating indications for repeated operations in Crohn’s disease: evidence for two clinical forms. / A.J.Greenstein et al. // Gut. - 1988. - 29 (5). - p. 588-592.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Hanauer, S.B. Postoperative maintenance of Crohn’s disease remission with 6-mercaptopurine, mesalamine, or placebo: a 2-year trial. / S.B.Hanauer, B.I.Korelitz, P.Rutgeerts et al. // Gastroenterology. -2004. - 127. - p. 723-729.</mixed-citation><mixed-citation xml:lang="en">Hanauer, S.B. Postoperative maintenance of Crohn’s disease remission with 6-mercaptopurine, mesalamine, or placebo: a 2-year trial. / S.B.Hanauer, B.I.Korelitz, P.Rutgeerts et al. // Gastroenterology. -2004. - 127. - p. 723-729.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Harvey, R.F. A simple index of Crohn’s-disease activity. / R.F.Harvey, J.M.Bradshaw. // Lancet. -1980. - 1 (8167). - p. 514.</mixed-citation><mixed-citation xml:lang="en">Harvey, R.F. A simple index of Crohn’s-disease activity. / R.F.Harvey, J.M.Bradshaw. // Lancet. -1980. - 1 (8167). - p. 514.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Hashash, J.G. A Practical Approach to Preventing Postoperative Recurrence in Crohn’s Disease. /J.G.Hashash, M.Regueiro. // Curr. Gastroenterol. Rep. - 2016. - May. - 18 (5). - p. 25.</mixed-citation><mixed-citation xml:lang="en">Hashash, J.G. A Practical Approach to Preventing Postoperative Recurrence in Crohn’s Disease. /J.G.Hashash, M.Regueiro. // Curr. Gastroenterol. Rep. - 2016. - May. - 18 (5). - p. 25.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Hashash, J.G. The evolving management of postoperative Crohn’s disease. / J.G.Hashash, M.D.Regueiro // Expert Rev. Gastroenterol. Hepatol. - 2012. - 6 (5). - p. 637-48.</mixed-citation><mixed-citation xml:lang="en">Hashash, J.G. The evolving management of postoperative Crohn’s disease. / J.G.Hashash, M.D.Regueiro // Expert Rev. Gastroenterol. Hepatol. - 2012. - 6 (5). - p. 637-48.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Hellers, G. Crohn’s disease in Stockholm county 1955-1974. A study of epidemiology, results of surgical treatment and long-term prognosis. / G.Hellers // Acta. Chir. Scand. Int. J. Colorectal Disease. - 2007. -22 (9). - p. 1043-1049.</mixed-citation><mixed-citation xml:lang="en">Hellers, G. Crohn’s disease in Stockholm county 1955-1974. A study of epidemiology, results of surgical treatment and long-term prognosis. / G.Hellers // Acta. Chir. Scand. Int. J. Colorectal Disease. - 2007. -22 (9). - p. 1043-1049.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Herfarth, H.H. Inflamm Bowel. / H.H.Herfarth, A.J.Katz, S.B.Hanauer et al.// Dis. - 2013. - 19 (5). -p. 1073-1079.</mixed-citation><mixed-citation xml:lang="en">Herfarth, H.H. Inflamm Bowel. / H.H.Herfarth, A.J.Katz, S.B.Hanauer et al.// Dis. - 2013. - 19 (5). -p. 1073-1079.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Hofer, B. The impact of clinical types of disease manifestation on the risk of early postoperative recurrence in Crohn’s disease. / B.Hofer et al. // Hepatogastroenterology. - 2001. - 48 (37). - p. 152155.</mixed-citation><mixed-citation xml:lang="en">Hofer, B. The impact of clinical types of disease manifestation on the risk of early postoperative recurrence in Crohn’s disease. / B.Hofer et al. // Hepatogastroenterology. - 2001. - 48 (37). - p. 152155.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Jason, M. Swoger and Miguel Regueiro Preventive therapy in postoperative Crohn’sdisease. / M. Jason. // Current Opinion in Gastroenterology. - 2010. - 26. - p. 337-343.</mixed-citation><mixed-citation xml:lang="en">Jason, M. Swoger and Miguel Regueiro Preventive therapy in postoperative Crohn’sdisease. / M. Jason. // Current Opinion in Gastroenterology. - 2010. - 26. - p. 337-343.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Kane, S.V. Tobacco use is associated with accelerated clinical recurrence of Crohn’s disease after surgically induced remission. / S.V.Kane, M.Flicker, F.Katz-Nelson // J. Clin. Gastroenterol. - 2005. -39 (1). - p. 32-35.</mixed-citation><mixed-citation xml:lang="en">Kane, S.V. Tobacco use is associated with accelerated clinical recurrence of Crohn’s disease after surgically induced remission. / S.V.Kane, M.Flicker, F.Katz-Nelson // J. Clin. Gastroenterol. - 2005. -39 (1). - p. 32-35.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Latella, G. Results of the 4th scientific workshop of the ECCO (I): pathophysiology of intestinal fibrosis in IBD. / G.Latella, G.Rogler, G.Bamias et al. // J. Crohns Colitis. - 2014. - pii: S1873-9946 (14) 00120-S1873-9946(14) 00122.</mixed-citation><mixed-citation xml:lang="en">Latella, G. Results of the 4th scientific workshop of the ECCO (I): pathophysiology of intestinal fibrosis in IBD. / G.Latella, G.Rogler, G.Bamias et al. // J. Crohns Colitis. - 2014. - pii: S1873-9946 (14) 00120-S1873-9946(14) 00122.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">McLeod, R.S. Prophylactic mesalamine treatment decreases postoperative recurrence of Crohn’s disease. / R.S.McLeod, B.G.Wolff, A.H.Steinhart et al. // Gastroenterology. - 1995. - 109. - p. 404-413.</mixed-citation><mixed-citation xml:lang="en">McLeod, R.S. Prophylactic mesalamine treatment decreases postoperative recurrence of Crohn’s disease. / R.S.McLeod, B.G.Wolff, A.H.Steinhart et al. // Gastroenterology. - 1995. - 109. - p. 404-413.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Michelassi, F. Primary and recurrent Crohn’s disease. Experience with 1379 patients. / F.Michelassi, T.Balestracci, R.Chappel et al. // Ann. Surg. - 1991. -214. - p. 230-238.</mixed-citation><mixed-citation xml:lang="en">Michelassi, F. Primary and recurrent Crohn’s disease. Experience with 1379 patients. / F.Michelassi, T.Balestracci, R.Chappel et al. // Ann. Surg. - 1991. -214. - p. 230-238.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Modigliani, R. Clinical, biological and endoscopy picture of attacks of Crohn’s disease. Evolution on prednisolone. / R.Modigliani, J.Mary, J.Simon // Gastroenterology. - 1990. - 98. - p. 811-818.</mixed-citation><mixed-citation xml:lang="en">Modigliani, R. Clinical, biological and endoscopy picture of attacks of Crohn’s disease. Evolution on prednisolone. / R.Modigliani, J.Mary, J.Simon // Gastroenterology. - 1990. - 98. - p. 811-818.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Ng, S.C. Management of postoperative Crohn’s disease. / S.C.Ng, M.A.Kamm // Am. J. Gastroenterol. - 2008. - 103 (4). - p. 1029-1035.</mixed-citation><mixed-citation xml:lang="en">Ng, S.C. Management of postoperative Crohn’s disease. / S.C.Ng, M.A.Kamm // Am. J. Gastroenterol. - 2008. - 103 (4). - p. 1029-1035.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Otley, A. Budesonide for induction of remission in Crohn’s disease. / A.Otley, AH.Steinhart // Cochrane Database Syst. Rev. - 2005. - CD000296. - Review.</mixed-citation><mixed-citation xml:lang="en">Otley, A. Budesonide for induction of remission in Crohn’s disease. / A.Otley, AH.Steinhart // Cochrane Database Syst. Rev. - 2005. - CD000296. - Review.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Papamichael, K. Adalimumab for the prevention and/or treatment of post-operative recurrence of Crohn’s disease: a prospective, two-year, single center, pilot study. / K.Papamichael, E.Archavlis, C.Lariou et al. // J. Crohns Colitis. - 2012. - 6 (9). - p. 924-931.</mixed-citation><mixed-citation xml:lang="en">Papamichael, K. Adalimumab for the prevention and/or treatment of post-operative recurrence of Crohn’s disease: a prospective, two-year, single center, pilot study. / K.Papamichael, E.Archavlis, C.Lariou et al. // J. Crohns Colitis. - 2012. - 6 (9). - p. 924-931.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Peyrin-Biroulet, L. Azathioprine and 6-mercaptopurine for the prevention of postoperative recurrence in Crohn’s disease: a meta-analysis. / L.Peyrin-Biroulet, P.Deltenre, S.Ardizzone et al. // Am. J. Gastroenterol. - 2009. - 104. - p. 2089-2096.</mixed-citation><mixed-citation xml:lang="en">Peyrin-Biroulet, L. Azathioprine and 6-mercaptopurine for the prevention of postoperative recurrence in Crohn’s disease: a meta-analysis. / L.Peyrin-Biroulet, P.Deltenre, S.Ardizzone et al. // Am. J. Gastroenterol. - 2009. - 104. - p. 2089-2096.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Peyrin-Biroulet, L. Surgery in a population-based cohort of Crohn’s disease from Olmsted County, Minnesota (1970-2004). / L.Peyrin-Biroulet, W.S.Harmsen, W.J.Tremaine et al. // Am. J. Gastroenterol. - 2012. - 107. - p. 1693-1701.</mixed-citation><mixed-citation xml:lang="en">Peyrin-Biroulet, L. Surgery in a population-based cohort of Crohn’s disease from Olmsted County, Minnesota (1970-2004). / L.Peyrin-Biroulet, W.S.Harmsen, W.J.Tremaine et al. // Am. J. Gastroenterol. - 2012. - 107. - p. 1693-1701.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Reese, G.E. The effect of smoking after surgery for Crohn’s disease: a meta-analysis of observational studies. / G.E.Reese, T.Nanidis, C.Borysiewicz et al. // Int. J. Color Dis. - 2008. - 23 (12). - p. 1213-1221.</mixed-citation><mixed-citation xml:lang="en">Reese, G.E. The effect of smoking after surgery for Crohn’s disease: a meta-analysis of observational studies. / G.E.Reese, T.Nanidis, C.Borysiewicz et al. // Int. J. Color Dis. - 2008. - 23 (12). - p. 1213-1221.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Regueiro, M. Infliximab prevents Crohn’s disease recurrence after ileal resection. / M.Regueiro, W.Schraut, L.Baidoo et al. // Gastroenterology. -2009. - 136 (2). - p. 441-450.</mixed-citation><mixed-citation xml:lang="en">Regueiro, M. Infliximab prevents Crohn’s disease recurrence after ileal resection. / M.Regueiro, W.Schraut, L.Baidoo et al. // Gastroenterology. -2009. - 136 (2). - p. 441-450.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Regueiro, M. Infliximab Reduces Endoscopic, but not Clinical, Recurrence of Crohn’s Disease Following Ileocolonic Resection. / M.Regueiro, B.G.Feagan, B.Zou et al. // Gastroenterology. - 2016. - 150 (7).</mixed-citation><mixed-citation xml:lang="en">Regueiro, M. Infliximab Reduces Endoscopic, but not Clinical, Recurrence of Crohn’s Disease Following Ileocolonic Resection. / M.Regueiro, B.G.Feagan, B.Zou et al. // Gastroenterology. - 2016. - 150 (7).</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Regueiro, M. Postoperative infliximab is not associated with an increase in adverse events in Crohn’s disease. / M.Regueiro, S.El-Hachem, K.E.Kip et al. // Dig. Dis. Sci. - 2011. - 56 (12). - p. 3610-3615.</mixed-citation><mixed-citation xml:lang="en">Regueiro, M. Postoperative infliximab is not associated with an increase in adverse events in Crohn’s disease. / M.Regueiro, S.El-Hachem, K.E.Kip et al. // Dig. Dis. Sci. - 2011. - 56 (12). - p. 3610-3615.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Regueiro, M. Postoperative therapy with infliximab prevents long-term Crohn’s disease recurrence. / M.Regueiro, K.E.Kip, L.Baidoo et al. // Clin. Gastroenterol. Hepatol. - 2014. - 12. - p. 1494-502.</mixed-citation><mixed-citation xml:lang="en">Regueiro, M. Postoperative therapy with infliximab prevents long-term Crohn’s disease recurrence. / M.Regueiro, K.E.Kip, L.Baidoo et al. // Clin. Gastroenterol. Hepatol. - 2014. - 12. - p. 1494-502.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Rutgeerts, P. Controlled trial of metronidazole treatment for prevention of Crohn’s recurrence after ileal resection. / P.Rutgeerts, M.Hiele, K.Geboes et al. // Gastroenterology. - 1995. - 108. - Р. 1617-1621.</mixed-citation><mixed-citation xml:lang="en">Rutgeerts, P. Controlled trial of metronidazole treatment for prevention of Crohn’s recurrence after ileal resection. / P.Rutgeerts, M.Hiele, K.Geboes et al. // Gastroenterology. - 1995. - 108. - Р. 1617-1621.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Rutgeerts, P. Ornidazole for prophylaxis of postoperative Crohn’s disease recurrence: a randomized, double-blind, placebo-controlled trial. / P.Rutgeerts et al. // Gastroenterology. - 2005. -128 (4). - p. 856-861.</mixed-citation><mixed-citation xml:lang="en">Rutgeerts, P. Ornidazole for prophylaxis of postoperative Crohn’s disease recurrence: a randomized, double-blind, placebo-controlled trial. / P.Rutgeerts et al. // Gastroenterology. - 2005. -128 (4). - p. 856-861.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Sakuraba, A. The use of infliximab in the prevention of postsurgical recurrence in polysurgeryCrohn’s disease patients: a pilot open-labeled prospective study. / A.Sakuraba, T.Sato, H.Matsukawa et al. // Int. J. Colorectal Dis. - 2012. - 27 (7) - p. 947-952.</mixed-citation><mixed-citation xml:lang="en">Sakuraba, A. The use of infliximab in the prevention of postsurgical recurrence in polysurgeryCrohn’s disease patients: a pilot open-labeled prospective study. / A.Sakuraba, T.Sato, H.Matsukawa et al. // Int. J. Colorectal Dis. - 2012. - 27 (7) - p. 947-952.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Savarino, E. Adalimumab is more effective than azathioprine and mesalamine at preventing postoperative recurrence of Crohn’s disease: a randomized controlled trial. / E.Savarino, G.Bodini, P.Dulbecco et al. // Am. J. Gastroenterol. - 2013. - 108 (11). - p. 1731-1742.</mixed-citation><mixed-citation xml:lang="en">Savarino, E. Adalimumab is more effective than azathioprine and mesalamine at preventing postoperative recurrence of Crohn’s disease: a randomized controlled trial. / E.Savarino, G.Bodini, P.Dulbecco et al. // Am. J. Gastroenterol. - 2013. - 108 (11). - p. 1731-1742.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Savarino, E. Prevention of postoperative recurrence of Crohn’s disease by Adalimumab: a case series. / E.Savarino, P.Dulbecco, G.Bodini et al. // Eur. J. Gastroenterol. Hepatol. - 2012. - 24 (4). -p. 468-70.</mixed-citation><mixed-citation xml:lang="en">Savarino, E. Prevention of postoperative recurrence of Crohn’s disease by Adalimumab: a case series. / E.Savarino, P.Dulbecco, G.Bodini et al. // Eur. J. Gastroenterol. Hepatol. - 2012. - 24 (4). -p. 468-70.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Simillis, C. A meta-analysis comparing incidence of recurrence and indication for reoperation after surgery for perforating versus nonperforating Crohn’s disease. / C.Simillis, T.Yamamoto, G.E.Reese et al. // Am. J. Gastroenterol. - 2008. - 103 (1). - p. 196-205.</mixed-citation><mixed-citation xml:lang="en">Simillis, C. A meta-analysis comparing incidence of recurrence and indication for reoperation after surgery for perforating versus nonperforating Crohn’s disease. / C.Simillis, T.Yamamoto, G.E.Reese et al. // Am. J. Gastroenterol. - 2008. - 103 (1). - p. 196-205.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Sorrentino, D. Infliximab with low-dose methotrexate for prevention of postsurgical recurrence of ileocolonic Crohn disease. / D.Sorrentino, G.Terrosu, C.Avellini et al. // Arch. Intern. Med. -2007. - 167 (16). - p. 1804-1807.</mixed-citation><mixed-citation xml:lang="en">Sorrentino, D. Infliximab with low-dose methotrexate for prevention of postsurgical recurrence of ileocolonic Crohn disease. / D.Sorrentino, G.Terrosu, C.Avellini et al. // Arch. Intern. Med. -2007. - 167 (16). - p. 1804-1807.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Sorrentino, D. Low-dose maintenance therapy with infliximab prevents postsurgical recurrence of Crohn’s disease. / D.Sorrentino, A.Paviotti, G.Terrosu et al. // Clin. Gastroenterol. Hepatol. - 2010. - 8 (7). -p. 591-599.</mixed-citation><mixed-citation xml:lang="en">Sorrentino, D. Low-dose maintenance therapy with infliximab prevents postsurgical recurrence of Crohn’s disease. / D.Sorrentino, A.Paviotti, G.Terrosu et al. // Clin. Gastroenterol. Hepatol. - 2010. - 8 (7). -p. 591-599.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Sorrentino, D. Prevention of postoperative recurrence of Crohn’s disease by infliximab. / D.Sorrentino, G.Terrosu, C.Avellini et al. // Eur. J. Gastroenterol. Hepatol. - 2006. - 18 (4). - p. 457-459.</mixed-citation><mixed-citation xml:lang="en">Sorrentino, D. Prevention of postoperative recurrence of Crohn’s disease by infliximab. / D.Sorrentino, G.Terrosu, C.Avellini et al. // Eur. J. Gastroenterol. Hepatol. - 2006. - 18 (4). - p. 457-459.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Sorrentino, D. State-of-the-art medical prevention of postoperative recurrence of Crohn’s disease. / D.Sorrentino. // Nat. Rev. Gastroenterol. Hepatol. -2013. - 10 (7). - p. 413-422.</mixed-citation><mixed-citation xml:lang="en">Sorrentino, D. State-of-the-art medical prevention of postoperative recurrence of Crohn’s disease. / D.Sorrentino. // Nat. Rev. Gastroenterol. Hepatol. -2013. - 10 (7). - p. 413-422.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Steinhart, A.H. Corticosteroids for maintaining remission of Crohn’s disease. / A.H.Steinhart, K.Ewe, A.M.Griffiths et al. // Cochrane Database Syst. Rev. - 2003. - CD000301.</mixed-citation><mixed-citation xml:lang="en">Steinhart, A.H. Corticosteroids for maintaining remission of Crohn’s disease. / A.H.Steinhart, K.Ewe, A.M.Griffiths et al. // Cochrane Database Syst. Rev. - 2003. - CD000301.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Terdiman, J.P. Prevention of postoperative recurrence in Crohn’s disease. / J.P.Terdiman. // Clin. Gastroenterol. Hepatol. - 2008. - 6 (6). - p. 616620.</mixed-citation><mixed-citation xml:lang="en">Terdiman, J.P. Prevention of postoperative recurrence in Crohn’s disease. / J.P.Terdiman. // Clin. Gastroenterol. Hepatol. - 2008. - 6 (6). - p. 616620.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Yamamoto, T. Factors affecting recurrence after surgery for Crohn’sdisease. / T.Yamamoto. // World. J. Gastroenterol. - 2005. - 11 (26). - p. 3971-3979.</mixed-citation><mixed-citation xml:lang="en">Yamamoto, T. Factors affecting recurrence after surgery for Crohn’sdisease. / T.Yamamoto. // World. J. Gastroenterol. - 2005. - 11 (26). - p. 3971-3979.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Yamamoto, T. Strategies for 25. the prevention of postoperative recurrence of Crohn’s disease. / T.Yamamoto, T.Watanabe. // Colorectal Disease. - 2013. - 15 (12). - p. 1471-1480.</mixed-citation><mixed-citation xml:lang="en">Yamamoto, T. Strategies for 25. the prevention of postoperative recurrence of Crohn’s disease. / T.Yamamoto, T.Watanabe. // Colorectal Disease. - 2013. - 15 (12). - p. 1471-1480.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
