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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gnck</journal-id><journal-title-group><journal-title xml:lang="ru">Колопроктология</journal-title><trans-title-group xml:lang="en"><trans-title>Koloproktologia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-7556</issn><issn pub-type="epub">2686-7303</issn><publisher><publisher-name>Russian Association of Coloproctology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33878/2073-7556-2017-0-2-100-104</article-id><article-id custom-type="elpub" pub-id-type="custom">gnck-313</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>МИКРОСАТЕЛЛИТНАЯ НЕСТАБИЛЬНОСТЬ ПРИ КОЛОРЕКТАЛЬНОМ РАКЕ (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>MICROSATELLITE INSTABILITY IN COLORECTAL CANCER (review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цуканов</surname><given-names>Алексей Сергеевич</given-names></name><name name-style="western" xml:lang="en"><surname>Tsukanov</surname><given-names>A. S.</given-names></name></name-alternatives><email xlink:type="simple">info@gnck.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шелыгин</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shelygin</surname><given-names>Yu. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шубин</surname><given-names>В. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Shubin</surname><given-names>V. P.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «ГНЦК им.А.Н. Рыжих» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Scientific Centre of Coloproctology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>30</day><month>06</month><year>2017</year></pub-date><volume>0</volume><issue>2</issue><fpage>100</fpage><lpage>104</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Цуканов А.С., Шелыгин Ю.А., Шубин В.П., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Цуканов А.С., Шелыгин Ю.А., Шубин В.П.</copyright-holder><copyright-holder xml:lang="en">Tsukanov A.S., Shelygin Y.A., Shubin V.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ruproctology.com/jour/article/view/313">https://www.ruproctology.com/jour/article/view/313</self-uri><kwd-group xml:lang="ru"><kwd>колоректальный рак</kwd><kwd>микросателлитная нестабильность</kwd><kwd>синдром Линча</kwd><kwd>ген BRAF</kwd></kwd-group><kwd-group xml:lang="en"><kwd>colorectal cancer</kwd><kwd>microsatellite instability</kwd><kwd>Lynch syndrome</kwd><kwd>BRAF gene</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Семенов Д.А., Ачкасов С.И., Цуканов А.С. и соавт. Синдром Линча. От «семьи G» до ДНК-диагностики. Колопроктология. - 2014. - №3. - с. 57-61.</mixed-citation><mixed-citation xml:lang="en">Семенов Д.А., Ачкасов С.И., Цуканов А.С. и соавт. Синдром Линча. От «семьи G» до ДНК-диагностики. Колопроктология. - 2014. - №3. - с. 57-61.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Федянин М.Ю., Трякин А.А., Тюляндин С.А. Роль микросателлитной нестабильности при раке толстой кишки. Онкологическая колопроктология. - 2012. - №3. - с. 19-25.</mixed-citation><mixed-citation xml:lang="en">Федянин М.Ю., Трякин А.А., Тюляндин С.А. Роль микросателлитной нестабильности при раке толстой кишки. Онкологическая колопроктология. - 2012. - №3. - с. 19-25.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Цуканов А.С., Поспехова Н.И., Шубин В.П. и соавт. Дифференциальный диагноз синдрома Линча от других форм неполипозного колоректального рака среди российских пациентов. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. - 2014. - т. 24. - №2. - с. 78-84.</mixed-citation><mixed-citation xml:lang="en">Цуканов А.С., Поспехова Н.И., Шубин В.П. и соавт. Дифференциальный диагноз синдрома Линча от других форм неполипозного колоректального рака среди российских пациентов. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. - 2014. - т. 24. - №2. - с. 78-84.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Чернышов С.В. Скрининг колоректального рака. Обзор литературы. Колопроктология. - 2009. -№ 2. - с. 55-59.</mixed-citation><mixed-citation xml:lang="en">Чернышов С.В. Скрининг колоректального рака. Обзор литературы. Колопроктология. - 2009. -№ 2. - с. 55-59.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Янус Г.А., Корнилов А.В., Суспицын Е.Н. и соавт. Молекулярно-генетическая диагностика наследственного неполипозного рака толстой кишки. Сибирский онкологический журнал. - 2012. -№ 2. - с. 29-38.</mixed-citation><mixed-citation xml:lang="en">Янус Г.А., Корнилов А.В., Суспицын Е.Н. и соавт. Молекулярно-генетическая диагностика наследственного неполипозного рака толстой кишки. Сибирский онкологический журнал. - 2012. -№ 2. - с. 29-38.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Berg A., Armstrong K., Botkin J. et al. Recommendations from the EGAPP Working Group: genetic testing strategies in newly diagnosed individuals with colorectal cancer aimed at reducing morbidity and mortality from Lynch syndrome in relatives. Genet. Med. - 2009 Jan; 11 (1): 35-41.</mixed-citation><mixed-citation xml:lang="en">Berg A., Armstrong K., Botkin J. et al. Recommendations from the EGAPP Working Group: genetic testing strategies in newly diagnosed individuals with colorectal cancer aimed at reducing morbidity and mortality from Lynch syndrome in relatives. Genet. Med. - 2009 Jan; 11 (1): 35-41.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Dietmaier W., Wallinger S., Bocker T. et al. Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression. Cancer. Res. - 1997 Nov; 57 (21): 4749-56.</mixed-citation><mixed-citation xml:lang="en">Dietmaier W., Wallinger S., Bocker T. et al. Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression. Cancer. Res. - 1997 Nov; 57 (21): 4749-56.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Engel C., Forberg C., Holinski-Feder E. et al. Novel strategy for optimal sequential application of clinical criteria, immunohistochemistry and microsatellite analysis in the diagnosis of hereditary nonpolyposis colorectal cancer. Int. J. Cancer. - 2006 Jan 1; 118 (1): 115-22.</mixed-citation><mixed-citation xml:lang="en">Engel C., Forberg C., Holinski-Feder E. et al. Novel strategy for optimal sequential application of clinical criteria, immunohistochemistry and microsatellite analysis in the diagnosis of hereditary nonpolyposis colorectal cancer. Int. J. Cancer. - 2006 Jan 1; 118 (1): 115-22.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Evans D.G., Walsh S., Hill J. et al. Strategies for identifying hereditary nonpolyposis colon cancer. Semin. Oncol. - 2007 Oct; 34 (5): 411-7.</mixed-citation><mixed-citation xml:lang="en">Evans D.G., Walsh S., Hill J. et al. Strategies for identifying hereditary nonpolyposis colon cancer. Semin. Oncol. - 2007 Oct; 34 (5): 411-7.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Giardiello F., Allen J., Axilbund J. et al. Guidelines on Genetic Evaluation and Management of Lynch Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer. Dis. Colon. Rectum. - 2014 Aug; 57 (8): 1025-48.</mixed-citation><mixed-citation xml:lang="en">Giardiello F., Allen J., Axilbund J. et al. Guidelines on Genetic Evaluation and Management of Lynch Syndrome: A Consensus Statement by the US Multi-Society Task Force on Colorectal Cancer. Dis. Colon. Rectum. - 2014 Aug; 57 (8): 1025-48.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Gruber S. New developments in Lynch syndrome (hereditary nonpolyposis colorectal cancer) and mismatch repair gene testing. Gastroenterology. - 2006 Feb; 130 (2): 577-87.</mixed-citation><mixed-citation xml:lang="en">Gruber S. New developments in Lynch syndrome (hereditary nonpolyposis colorectal cancer) and mismatch repair gene testing. Gastroenterology. - 2006 Feb; 130 (2): 577-87.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">lonov Y., Peinado M., Malkhosyan S. et al. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colorectal carcinogenesis. Nature. - 1993 Jun 10; 363 (6429): 558-61.</mixed-citation><mixed-citation xml:lang="en">lonov Y., Peinado M., Malkhosyan S. et al. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colorectal carcinogenesis. Nature. - 1993 Jun 10; 363 (6429): 558-61.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Kakar S., Burgart L.J., Thibodeau S.N. et al. Frequency of loss of hMLH1 expression in colorectal carcinoma increases with advancing age. Cancer. - 2003 Mar 15; 97 (6): 1421-7.</mixed-citation><mixed-citation xml:lang="en">Kakar S., Burgart L.J., Thibodeau S.N. et al. Frequency of loss of hMLH1 expression in colorectal carcinoma increases with advancing age. Cancer. - 2003 Mar 15; 97 (6): 1421-7.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Klingbiel D., Saridaki Z., Roth A. et al. Prognosis of stage II and III colon cancer treated with adjuvant 5-fluorouracil or FOLFIRI in relation to microsatellite status: results of the PETACC-3 trial. Ann. Oncol. 2015 Jan; 26 (1): 126-32</mixed-citation><mixed-citation xml:lang="en">Klingbiel D., Saridaki Z., Roth A. et al. Prognosis of stage II and III colon cancer treated with adjuvant 5-fluorouracil or FOLFIRI in relation to microsatellite status: results of the PETACC-3 trial. Ann. Oncol. 2015 Jan; 26 (1): 126-32</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Le D., Uram J., Wang H. et al. PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N. Engl. J. Med. - 2015 Jun 25; 372 (26): 2509-20.</mixed-citation><mixed-citation xml:lang="en">Le D., Uram J., Wang H. et al. PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N. Engl. J. Med. - 2015 Jun 25; 372 (26): 2509-20.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Lochhead P., Kuchiba A., Imamura Y. et al. Microsatellite instability and BRAF mutation testing in colorectal cancer prognostication. J. Natl. Cancer Inst. - 2013 Aug 7; 105 (15): 1151-6.</mixed-citation><mixed-citation xml:lang="en">Lochhead P., Kuchiba A., Imamura Y. et al. Microsatellite instability and BRAF mutation testing in colorectal cancer prognostication. J. Natl. Cancer Inst. - 2013 Aug 7; 105 (15): 1151-6.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Lynch H.T., Shaw M.W., Magnuson C.W. et al. Hereditary factors in cancer: study of two large Midwestern kindreds. Arch. Intern. Med. - 1966 Feb; 117 (2): 206-12.</mixed-citation><mixed-citation xml:lang="en">Lynch H.T., Shaw M.W., Magnuson C.W. et al. Hereditary factors in cancer: study of two large Midwestern kindreds. Arch. Intern. Med. - 1966 Feb; 117 (2): 206-12.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Makrodouli E., Oikonomou E., Koc M. et al. BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study. Mol. Cancer. - 2011 Sep 23; 10: 118.</mixed-citation><mixed-citation xml:lang="en">Makrodouli E., Oikonomou E., Koc M. et al. BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study. Mol. Cancer. - 2011 Sep 23; 10: 118.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Nakaji Y., Oki E., Nakanishi R. et al. Prognostic value of BRAF V600E mutation and microsatellite instability in Japanese patients with sporadic colorectal cancer.J. Cancer. Res. Clin. Oncol. - 2016 Sep 26. [Epub ahead of print].</mixed-citation><mixed-citation xml:lang="en">Nakaji Y., Oki E., Nakanishi R. et al. Prognostic value of BRAF V600E mutation and microsatellite instability in Japanese patients with sporadic colorectal cancer.J. Cancer. Res. Clin. Oncol. - 2016 Sep 26. [Epub ahead of print].</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Peltomaki P., Aaltonen. L.A., Sistonen P. et al. Genetic mapping of a locus predisposing to human colorectal cancer. Science. - 1993 May 7; 260 (5109): 810-2.</mixed-citation><mixed-citation xml:lang="en">Peltomaki P., Aaltonen. L.A., Sistonen P. et al. Genetic mapping of a locus predisposing to human colorectal cancer. Science. - 1993 May 7; 260 (5109): 810-2.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Potter J., Lindor N. Genetics of colorectal cancer. Springer. - 2008. - р. 185.</mixed-citation><mixed-citation xml:lang="en">Potter J., Lindor N. Genetics of colorectal cancer. Springer. - 2008. - р. 185.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Rahner N., Steinke V., Schlegelberger B. et al. Clinical utility gene card for: Lynch syndrome (MLH1, MSH2, MSH6, PMS2). Eur. J. Hum. Genet. - 2010 Sep; 18 (9).</mixed-citation><mixed-citation xml:lang="en">Rahner N., Steinke V., Schlegelberger B. et al. Clinical utility gene card for: Lynch syndrome (MLH1, MSH2, MSH6, PMS2). Eur. J. Hum. Genet. - 2010 Sep; 18 (9).</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Roth A.D., Tejpar S., Delorenzi M. et al. Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial. J. Clin. Oncol. - 2010 Jan 20; 28 (3): 466-74.</mixed-citation><mixed-citation xml:lang="en">Roth A.D., Tejpar S., Delorenzi M. et al. Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial. J. Clin. Oncol. - 2010 Jan 20; 28 (3): 466-74.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Suraweera N., Duval A., Reperant M. et al. Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR. Gastroenterology. - 2002 Dec; 123 (6): 1804-11.</mixed-citation><mixed-citation xml:lang="en">Suraweera N., Duval A., Reperant M. et al. Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR. Gastroenterology. - 2002 Dec; 123 (6): 1804-11.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Thibodeau S.N., Bren G., Schaid D.J. Microsalellite instability in cancer of the proximal colon. Science. - 1993 May 7; 260 (5109): 816-9.</mixed-citation><mixed-citation xml:lang="en">Thibodeau S.N., Bren G., Schaid D.J. Microsalellite instability in cancer of the proximal colon. Science. - 1993 May 7; 260 (5109): 816-9.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Thibodeau S., French A., Cunningham J. et al. Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1. Cancer. Res. - 1998 Apr 15; 58 (8): 1713-8.</mixed-citation><mixed-citation xml:lang="en">Thibodeau S., French A., Cunningham J. et al. Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1. Cancer. Res. - 1998 Apr 15; 58 (8): 1713-8.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Umar A., Boland C., Terdiman J. et al. Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl. Cancer Inst. - 2004 Feb 18; 96 (4): 261-8.</mixed-citation><mixed-citation xml:lang="en">Umar A., Boland C., Terdiman J. et al. Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl. Cancer Inst. - 2004 Feb 18; 96 (4): 261-8.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Vasen H.F., Mecklin J.P., Khan P.M. et al. International Collaborative Group on hereditary non-polyposis colorectal cancer (ICG-HNPCC). Dis. Colon Rectum. - 1991 May; 34 (5): 424-5.</mixed-citation><mixed-citation xml:lang="en">Vasen H.F., Mecklin J.P., Khan P.M. et al. International Collaborative Group on hereditary non-polyposis colorectal cancer (ICG-HNPCC). Dis. Colon Rectum. - 1991 May; 34 (5): 424-5.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Vasen H., Moslein G., Alonso A. et al. Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer). J. Med. Genet. - 2007 Jun; 44 (6): 353-62.</mixed-citation><mixed-citation xml:lang="en">Vasen H., Moslein G., Alonso A. et al. Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer). J. Med. Genet. - 2007 Jun; 44 (6): 353-62.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Vasen H.F., Watsan P., Mecklin J.P. et al. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology. - 1999 Jun; 116 (6): 1453-6.</mixed-citation><mixed-citation xml:lang="en">Vasen H.F., Watsan P., Mecklin J.P. et al. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology. - 1999 Jun; 116 (6): 1453-6.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Venderbosch S., Nagtegaal I., Maughan T. et al. Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: a pooled analysis of the CAIRO, CAIRO2, COIN, and FOCUS studies. Clin. Cancer Res. - 2014. - 15; 20 (20): 5322-30.</mixed-citation><mixed-citation xml:lang="en">Venderbosch S., Nagtegaal I., Maughan T. et al. Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: a pooled analysis of the CAIRO, CAIRO2, COIN, and FOCUS studies. Clin. Cancer Res. - 2014. - 15; 20 (20): 5322-30.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Warthin A.S. Heredity with reference to carcinoma as shown by the study of the cases examined in the Pathological Laboratory of the University of Michigan, 1895-1912. Arch. Int. Med. - 1913; 12: 546-55.</mixed-citation><mixed-citation xml:lang="en">Warthin A.S. Heredity with reference to carcinoma as shown by the study of the cases examined in the Pathological Laboratory of the University of Michigan, 1895-1912. Arch. Int. Med. - 1913; 12: 546-55.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Wellbrock C., Karasarides M., Marais R. The RAF proteins take centre stage. Nat. Rev. Mol. Cell. Biol. - 2004 Nov; 5 (11): 875-85.</mixed-citation><mixed-citation xml:lang="en">Wellbrock C., Karasarides M., Marais R. The RAF proteins take centre stage. Nat. Rev. Mol. Cell. Biol. - 2004 Nov; 5 (11): 875-85.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Yuan L., Chi Y., Chen W. et al. Immunohistochemistry and microsatellite instability analysis in molecular subtyping of colorectal carcinoma based on mismatch repair competency. Int. J. Clin. Exp. - Med. 2015 Nov 15; 8 (11): 20988-1000.</mixed-citation><mixed-citation xml:lang="en">Yuan L., Chi Y., Chen W. et al. Immunohistochemistry and microsatellite instability analysis in molecular subtyping of colorectal carcinoma based on mismatch repair competency. Int. J. Clin. Exp. - Med. 2015 Nov 15; 8 (11): 20988-1000.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
