gnckКолопроктологияKoloproktologia2073-75562686-7303Russian Association of Coloproctology10.33878/2073-7556-2025-24-3-201-208gnck-2018Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWБолезнь Крона червеобразного отростка. Обзор литературы с описанием отдаленного результата хирургического лечения через 37 летCrohn's disease of the appendix. Late outcome of surgery after 37 years (clinical case and review)https://orcid.org/0000-0003-1696-3146ТимербулатовВ. М.TimerbulatovV. M.

ул. Ленина, д. 3., Уфа, 450008

Vil M. Timerbulatov.

Lenina st., 3, Ufa, 450008

https://orcid.org/0000-0002-4832-6363ТимербулатовШ. В.TimerbulatovSh. V.

ул. Ленина, д. 3., Уфа, 450008

Shamil V. Timerbulatov.

Lenina st., 3, Ufa, 450008

https://orcid.org/0000-0001-9689-0949АитоваЛ. Р.AitovaL. R.

ул. Ленина, д. 3., Уфа, 450008

Liliya R. Aitova.

Lenina st., 3, Ufa, 450008

https://orcid.org/0009-0006-9617-9667ЛопатинД. В.LopatinD. V.

ул. Ленина, д. 3., Уфа, 450008

Denis V. Lopatin.

Lenina st., 3, Ufa, 450008

https://orcid.org/0000-0003-2874-7213ГафароваА. Р.GafarovaA. R.

Гафарова Айгуль Радиковна - кафедра хирургии и эндоскопии.

ул. Ленина, д. 3, Уфа, 450008

тел.: +7 (937) 303-58-88

Aigul R. Gafarova.

Lenina st., 3, Ufa, 450008

tel.: +7 (937) 303-58-88

argafarova@yandex.ruhttps://orcid.org/0000-0002-9351-4582АхмеровР. Р.AkhmerovR. R.

ул. Батырская, д. 39/2, Уфа, 450106

Ruslan R. Akhmerov.

Batyrskaya st., 39/2, Ufa, 450106

https://orcid.org/0009-0005-4710-7299ГаязовИ. Д.GayazovI. D.

ул. Батырская, д. 39/2, Уфа, 450106

Ilmir D. Gayazov.

Batyrskaya st., 39/2, Ufa, 450106

ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава РоссииРоссияBashkir State Medical UniversityRussian FederationГБУЗ «Клиническая больница скрой медицинской помощи» Минздрава Республики БашкортостанРоссияClinical Hospital of Emergency Medical CareRussian Federation202516082025243201208Copyright © Тимербулатов В.М., Тимербулатов Ш.В., Аитова Л.Р., Лопатин Д.В., Гафарова А.Р., Ахмеров Р.Р., Гаязов И.Д., 20252025Тимербулатов В.М., Тимербулатов Ш.В., Аитова Л.Р., Лопатин Д.В., Гафарова А.Р., Ахмеров Р.Р., Гаязов И.Д.Timerbulatov V.M., Timerbulatov S.V., Aitova L.R., Lopatin D.V., Gafarova A.R., Akhmerov R.R., Gayazov I.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.ruproctology.com/jour/article/view/2018ЦЕЛЬ

ЦЕЛЬ: на основании анализа собственного клинического наблюдения и литературного обзора рассмотреть проблему лечения болезни Крона червеобразного отростка.

ПАЦИЕНТЫ И МЕТОДЫ

ПАЦИЕНТЫ И МЕТОДЫ: приводится отдаленный результат (37 лет) пациентки, перенесшей в возрасте 28 лет правостороннюю гемиколэктомию по поводу болезни Крона червеобразного отростка. В течение указанных лет она не получала лечения по поводу данного заболевания. В 2024 году проведено комплексное клинико-инструментальное, молекулярно-генетическое исследование.

РЕЗУЛЬТАТЫ

РЕЗУЛЬТАТЫ: по результатам обследования, данных за рецидив болезни Крона не выявлено, однако при молекулярно-генетическом исследовании выявлены 2 клинически значимых генотипа, связанных с риском развития болезни Крона. Представлен обзор отечественной и иностранной литературы, включая роли брыжейки кишечника в патогенезе болезни Крона.

ЗАКЛЮЧЕНИЕ

ЗАКЛЮЧЕНИЕ: при изолированной форме болезни Крона червеобразного отростка аппендэктомия является приемлемым вариантом хирургического лечения; при поражении основания червеобразного отростка с вовлечением купола слепой кишки следует рассмотреть варианты резекции ободочной кишки.

Хирургические вмешательства приводят к выздоровлению/длительной ремиссии.

OBJECTIVE

OBJECTIVE: based on the analysis of our own clinical observation and literature review, to consider the problem of treatment of Crohn's disease of the appendix.

PATIENT AND METHODS

PATIENT AND METHODS: the long-term result (37 years old) of a patient who underwent right-sided hemicolectomy for Crohn's disease of the appendix at the age of 28 is presented. During these years, she did not receive treatment for this disease. In 2024, a comprehensive clinical, instrumental, and molecular genetic study was conducted.

RESULTS

RESULTS: According to the results of the examination, no data were found for the recurrence of Crohn's disease, however, a molecular genetic study revealed 2 clinically significant genotypes associated with the risk of Crohn's disease. A review of domestic and foreign literature is presented, including the role of the intestinal mesentery in the pathogenesis of Crohn's disease.

CONCLUSION

CONCLUSION: in the isolated form of Crohn's disease of the appendix, appendectomy is an acceptable surgical treatment option; if the base of the appendix is affected and the cecum dome is involved, colon resection options should be considered. Surgical interventions lead to recovery/long-term remission.

червеобразный отростокболезнь Кронахирургические вмешательстваотдаленные результатыappendixCrohn's diseasesurgical interventionslong-term resultsReferencesLopes S, Andrade P, Afonso J, et al. Monitoring Crohn's disease activity: endoscopy, fecal markers and computed tomography enterorrhaphy. Therap Adv Gastroenterol. 2018;11:1756284818769075.Lopes S, Andrade P, Afonso J, et al. Monitoring Crohn's disease activity: endoscopy, fecal markers and computed tomography enterorrhaphy. Therap Adv Gastroenterol. 2018;11:1756284818769075.Шелыгин Ю.А., Ивашкин В.Т., Ачкасов С.И., и соавт. Клинические рекомендации. Болезнь Крона (К50), взрослые. Колопроктология. 2023;22(3):10–49. doi: 10.33878/2073-7556-2023-22-3-10-49Shelygin Y.A., Ivashkin V.T., Achkasov S.I., et al. Clinical guideline. Crohn's disease (K50), adults. Koloproktologia. 2023;22(3):10–49. (In Russ.). doi: 10.33878/2073-7556-2023-22-3-10-49Herdem N, Sali DET. The Effectiveness of CT Enterography in the Radiological Evaluation of Crohn's Disease. Bagcilar Med Bull. 2021;6(3):257–263. doi: 10.4274/BMB.galenos.2021.02.020Herdem N, Sali DET. The Effectiveness of CT Enterography in the Radiological Evaluation of Crohn's Disease. Bagcilar Med Bull. 2021;6(3):257–263. doi: 10.4274/BMB.galenos.2021.02.020Carbo AI, Reddy T, Gates T, et al. The most characteristic lesions and radiologic signs of Crohn disease of the small bowel: air enteroclysis, MDCT, endoscopy, and pathology. Abdom Imaging. 2014;39(1):215–234.Carbo AI, Reddy T, Gates T, et al. The most characteristic lesions and radiologic signs of Crohn disease of the small bowel: air enteroclysis, MDCT, endoscopy, and pathology. Abdom Imaging. 2014;39(1):215–234.Machado NO, Chopra PJ, Hamdani AA. Crohn's disease of the appendix with enterocutaneous fistula postappendicectomy: an approach to management. N Am J Med Sci. 2010, 2:158–61.Machado NO, Chopra PJ, Hamdani AA. Crohn's disease of the appendix with enterocutaneous fistula postappendicectomy: an approach to management. N Am J Med Sci. 2010, 2:158–61.Meyerding EV, Bertram HF. Nonspecific granulomatous inflammation (Crohn's disease) of the appendix: a casereport. Surgery. 1953;34(5):891–894.Meyerding EV, Bertram HF. Nonspecific granulomatous inflammation (Crohn's disease) of the appendix: a casereport. Surgery. 1953;34(5):891–894.Dubrovskaya V, Shamah S, Weisberg I, et al. Crohn's appendicitis: 696. Am J Gastroenterol. 2015,110:307.Dubrovskaya V, Shamah S, Weisberg I, et al. Crohn's appendicitis: 696. Am J Gastroenterol. 2015,110:307.Sakamoto N, Nemoto Y, Masumoto K, et al. Crohn's disease with pathological findings of a granulomatous lesion in the appendix. J Pediatr Surg Case Rep. 2022,76:102121.10.1016/j.epsc.2021.102121Sakamoto N, Nemoto Y, Masumoto K, et al. Crohn's disease with pathological findings of a granulomatous lesion in the appendix. J Pediatr Surg Case Rep. 2022,76:102121.10.1016/j.epsc.2021.102121Gebbers J-O, Laissue J-A. Bacterial translocation in the normal human appendix parallels the development of the local immune system. Ann NY Acad Sci. 2004;1029:337–43.Gebbers J-O, Laissue J-A. Bacterial translocation in the normal human appendix parallels the development of the local immune system. Ann NY Acad Sci. 2004;1029:337–43.Bollinger RR, Barbas AS, Bush EL, et al. Biofilms in the large bowel suggest an apparent function of the human vermiform appendix. J Theor Biol. 2007;249:826–31.Bollinger RR, Barbas AS, Bush EL, et al. Biofilms in the large bowel suggest an apparent function of the human vermiform appendix. J Theor Biol. 2007;249:826–31.Im G, Modayil R, Lin C, et al. The appendix may protect against clostridium difficile recurrence. Clin Gastroenterol Hepatol. 2011;9:1072–7.Im G, Modayil R, Lin C, et al. The appendix may protect against clostridium difficile recurrence. Clin Gastroenterol Hepatol. 2011;9:1072–7.Sanders NL, Bollinger RR, Lee R, et al. Appendectomy and clostridium difficile colitis: relationships revealed by clinical observations and immunology. World J Gastroenterol. 2013;19:5607–14.Sanders NL, Bollinger RR, Lee R, et al. Appendectomy and clostridium difficile colitis: relationships revealed by clinical observations and immunology. World J Gastroenterol. 2013;19:5607–14.Radford-Smith G, Edwards J, Purdie D. Protective role of appendicectomy on onset and severity of ulcerative colitis and Crohn's disease. Gut. 2002;51:808–13.Radford-Smith G, Edwards J, Purdie D. Protective role of appendicectomy on onset and severity of ulcerative colitis and Crohn's disease. Gut. 2002;51:808–13.Gilat T, Hacohen D, Lilos P, et al. Childhood Factors in Ulcerative Colitis and Crohn's Disease: An International Cooperative Study. Scand J of Gastroenterol. 1987;22(8):1009–1024. doi: 10.3109/00365528708991950Gilat T, Hacohen D, Lilos P, et al. Childhood Factors in Ulcerative Colitis and Crohn's Disease: An International Cooperative Study. Scand J of Gastroenterol. 1987;22(8):1009–1024. doi: 10.3109/00365528708991950Sahami S, Kooij IA, Meijer SI, et al. The Link between the Appendix and Ulcerative Colitis: Clinical Relevance and Potential Immunological Mechanisms. Am J Gastroenterol. 2016;111:163–169. doi: 10.1038/ajg.2015.301Sahami S, Kooij IA, Meijer SI, et al. The Link between the Appendix and Ulcerative Colitis: Clinical Relevance and Potential Immunological Mechanisms. Am J Gastroenterol. 2016;111:163–169. doi: 10.1038/ajg.2015.301Frisch M, Pedersen BV, Andersson RE, et al. Appendicitis, mesenteric lymphadenitis, and subsequent risk of ulcerative colitis: cohort studies in Sweden and Denmark. BMJ. 2009;338:716.Frisch M, Pedersen BV, Andersson RE, et al. Appendicitis, mesenteric lymphadenitis, and subsequent risk of ulcerative colitis: cohort studies in Sweden and Denmark. BMJ. 2009;338:716.Singhal R, Taylor J, Owoniyi M, et al. Th e role of appendicectomy in the subsequent development of inflammatory bowel disease: A UK-based study. Int J Colorectal Dis. 2010;25:509–13.Singhal R, Taylor J, Owoniyi M, et al. Th e role of appendicectomy in the subsequent development of inflammatory bowel disease: A UK-based study. Int J Colorectal Dis. 2010;25:509–13.Kurina LM, Goldacre MJ, Yeates D, et al. Appendicectomy, tonsillectomy, and inflammatory bowel disease: a case-control record linkage study. J Study Highlights Epidemiol Community Health. 2002;56:551–4.Kurina LM, Goldacre MJ, Yeates D, et al. Appendicectomy, tonsillectomy, and inflammatory bowel disease: a case-control record linkage study. J Study Highlights Epidemiol Community Health. 2002;56:551–4.Hallas J, Gaist D, Vach W, et al. Appendicectomy has no beneficial effect on admission rates in patients with ulcerative colitis. Gut. 2004;53:351–4.Hallas J, Gaist D, Vach W, et al. Appendicectomy has no beneficial effect on admission rates in patients with ulcerative colitis. Gut. 2004;53:351–4.Cheluvappa R, Luo AS, Grimm MC, et al. T helper type 17 pathway suppression by appendicitis and appendectomy protects against colitis. Clin Exp Immunol. 2014;17:316–22.Cheluvappa R, Luo AS, Grimm MC, et al. T helper type 17 pathway suppression by appendicitis and appendectomy protects against colitis. Clin Exp Immunol. 2014;17:316–22.Cheluvappa R, Luoa S, Palmer C, et al. Protective pathways against colitis mediated by appendicitis and appendectomy. Clin Exp. 2011;165:393–400.Cheluvappa R, Luoa S, Palmer C, et al. Protective pathways against colitis mediated by appendicitis and appendectomy. Clin Exp. 2011;165:393–400.Andersson RE, Olaison G, Tysk C, et al. Appendectomy is followed by increased risk of Crohn's disease. Gastroenterology. 2003;124:40–6.Andersson RE, Olaison G, Tysk C, et al. Appendectomy is followed by increased risk of Crohn's disease. Gastroenterology. 2003;124:40–6.Richards M, Aberger FJ, Landercasper J. Granulomatous appendicitis: Crohn's disease, atypical Crohn's or not Crohn's at all? J Am Coll Surg. 1997;185:13–17.Richards M, Aberger FJ, Landercasper J. Granulomatous appendicitis: Crohn's disease, atypical Crohn's or not Crohn's at all? J Am Coll Surg. 1997;185:13–17.Tucker ON, Healy V, Jeffers M, et al. Granulomatous appendicitis. Surgeon. 2003;1:286–289.Tucker ON, Healy V, Jeffers M, et al. Granulomatous appendicitis. Surgeon. 2003;1:286–289.Bronner MP. Granulomatous appendicitis and the appendix in idiopathic inflammatory bowel disease. Semin Diagn Pathol. 2004;21:98–107.Bronner MP. Granulomatous appendicitis and the appendix in idiopathic inflammatory bowel disease. Semin Diagn Pathol. 2004;21:98–107.Mostyka M, Fulmer CG, Hissong EM, et al. Crohn Disease Infrequently Affects the Appendix and Rarely Causes Granulomatous Appendicitis. Am J Surg Pathol. 2021;45:1703–1706.Mostyka M, Fulmer CG, Hissong EM, et al. Crohn Disease Infrequently Affects the Appendix and Rarely Causes Granulomatous Appendicitis. Am J Surg Pathol. 2021;45:1703–1706.Han H, Kim A, Rehman SM, et al. Appendiceal Crohn's disease clinically presenting as acute appendicitis. World Journal of Clinical Cases. 2414;2(12):888–892, 2014.Han H, Kim A, Rehman SM, et al. Appendiceal Crohn's disease clinically presenting as acute appendicitis. World Journal of Clinical Cases. 2414;2(12):888–892, 2014.Prieto-Nieto JP, Perez-Robledo D, Hardisson JA, et al. Crohn's disease limited to the appendix. The American Journal of Surgery. 2001;182(5):531–533.Prieto-Nieto JP, Perez-Robledo D, Hardisson JA, et al. Crohn's disease limited to the appendix. The American Journal of Surgery. 2001;182(5):531–533.Yang SS, Gibson P, McCaughey RS, et al. Primary Crohn's disease of the appendix: report of 14 cases and review of the literature. Annals of Surgery. 1979;189(3):334–339.Yang SS, Gibson P, McCaughey RS, et al. Primary Crohn's disease of the appendix: report of 14 cases and review of the literature. Annals of Surgery. 1979;189(3):334–339.Jayarajah N, Navarathne N, Samarasekera N, et al. Epidemiology, pathogenesis and treatment of ulcerative colitis in South Asia. International Journal of Progressive Sciences and Technologies. 2017;6(1):205–212.Jayarajah N, Navarathne N, Samarasekera N, et al. Epidemiology, pathogenesis and treatment of ulcerative colitis in South Asia. International Journal of Progressive Sciences and Technologies. 2017;6(1):205–212.Yilmaz M, Akbulut S, Kutluturk K, et al. Unusual histopathological findings in appendectomy specimens from patients with suspected acute appendicitis. World J Gastroenterol. 2013;19:4015–4022.Yilmaz M, Akbulut S, Kutluturk K, et al. Unusual histopathological findings in appendectomy specimens from patients with suspected acute appendicitis. World J Gastroenterol. 2013;19:4015–4022.Guo G, Greenson JK. Histopathology of interval (delayed) appendectomyspecimens: strong association with granulomatous and xanthogranulomatous appendicitis. Am J Surg Pathol. 2003;27:1147–1151.Guo G, Greenson JK. Histopathology of interval (delayed) appendectomyspecimens: strong association with granulomatous and xanthogranulomatous appendicitis. Am J Surg Pathol. 2003;27:1147–1151.Roberts C, Hornick J, Mitsialis V, et al. Progressive Primary Appendiceal Crohn`s Disease in a 21-year-old Female. Case Report in Gastroenterology. 2020;14:504–509. doi: 10.1159/000508860Roberts C, Hornick J, Mitsialis V, et al. Progressive Primary Appendiceal Crohn`s Disease in a 21-year-old Female. Case Report in Gastroenterology. 2020;14:504–509. doi: 10.1159/000508860Fusari M, Sorrentino N, Bottazzi EC, et al. Primary signet ring cell-carcinoma of the appendix mimicking acute appendicitis. Acta Radiol Short Rep. 2012;1:arsr.2012.120017. doi: 10.1258/arsr.2012.120017Fusari M, Sorrentino N, Bottazzi EC, et al. Primary signet ring cell-carcinoma of the appendix mimicking acute appendicitis. Acta Radiol Short Rep. 2012;1:arsr.2012.120017. doi: 10.1258/arsr.2012.120017Mastoraki A, Papanikolaou IS, Kanakis D, et al. A case of signet ring carcinoma of the appendix:dilemmas in differential diagnosis and management. J Gastrointest Cancer. 2010;41:141–144. doi: 10.1007/s12029-009-9123-6Mastoraki A, Papanikolaou IS, Kanakis D, et al. A case of signet ring carcinoma of the appendix:dilemmas in differential diagnosis and management. J Gastrointest Cancer. 2010;41:141–144. doi: 10.1007/s12029-009-9123-6Murdock T, Lim N, Zenali M. Lymphangitic spread from the appendiceal adenocarcinoma to the ileocecal valve, mimicking Crohn's disease. World J Gastroenterol. 2015;21(7):2206–2209. doi: 10.3748/wjg.v21.i7.2206Murdock T, Lim N, Zenali M. Lymphangitic spread from the appendiceal adenocarcinoma to the ileocecal valve, mimicking Crohn's disease. World J Gastroenterol. 2015;21(7):2206–2209. doi: 10.3748/wjg.v21.i7.2206Ariel I, Vinograd I, Hershlag A, et al. Crohn's disease isolated to the appendix: truths and fallacies. Hum Pathol. 1986 Nov;17(11):1116–21. doi: 10.1016/s0046-8177(86)80416-6Ariel I, Vinograd I, Hershlag A, et al. Crohn's disease isolated to the appendix: truths and fallacies. Hum Pathol. 1986 Nov;17(11):1116–21. doi: 10.1016/s0046-8177(86)80416-6Akbulut S, Tas M, Sogutcu N, et al. Unusual histopathological findings in appendectomy specimens: a retrospective analysis and literature review. World J Gastroenterol. 2011 Apr 21;17(15):1961–70. doi: 10.3748/wjg.v17.i15.1961Akbulut S, Tas M, Sogutcu N, et al. Unusual histopathological findings in appendectomy specimens: a retrospective analysis and literature review. World J Gastroenterol. 2011 Apr 21;17(15):1961–70. doi: 10.3748/wjg.v17.i15.1961Emre A, Akbulut S, Bozdag Z, et al. Routine histopathologic examination of appendectomy specimens: retrospective analysis of 1255 patients. Int Surg. 2013 Oct-Dec;98(4):354–62. doi: 10.9738/INTSURG-D-13-00098.1Emre A, Akbulut S, Bozdag Z, et al. Routine histopathologic examination of appendectomy specimens: retrospective analysis of 1255 patients. Int Surg. 2013 Oct-Dec;98(4):354–62. doi: 10.9738/INTSURG-D-13-00098.1Yokota S, Togashi K, Kasahara N, et al. Crohn's disease confined to the appendix. Gastrointest Endosc. 2010 Nov;72(5):1063–4. doi: 10.1016/j.gie.2010.04.049Yokota S, Togashi K, Kasahara N, et al. Crohn's disease confined to the appendix. Gastrointest Endosc. 2010 Nov;72(5):1063–4. doi: 10.1016/j.gie.2010.04.049El-Saady, Ahmed MD. Crohn's disease limited to the appendix, case report. The Egyptian Journal of Surgery. Oct-Dec 2016;35(4):460–463. doi: 10.4103/1110-1121.194739El-Saady, Ahmed MD. Crohn's disease limited to the appendix, case report. The Egyptian Journal of Surgery. Oct-Dec 2016;35(4):460–463. doi: 10.4103/1110-1121.194739Gnanaselvam P, Weerakoon DN, Wijayasuriya WAM, et al. Isolated Crohn's Disease of the Appendix Presenting as Acute Appendicitis in a 60-Year-Old South Asian Female: A Case Report, Review of Literature, and Follow-Up Recommendations. Case Rep Surg. 2019 Oct 13;2019:5285417. doi: 10.1155/2019/5285417Gnanaselvam P, Weerakoon DN, Wijayasuriya WAM, et al. Isolated Crohn's Disease of the Appendix Presenting as Acute Appendicitis in a 60-Year-Old South Asian Female: A Case Report, Review of Literature, and Follow-Up Recommendations. Case Rep Surg. 2019 Oct 13;2019:5285417. doi: 10.1155/2019/5285417Crellin AJ, Musbahi O, Onwu N, et al. Appendiceal Crohn's disease: a rare differential of right iliac fossa pain. BMJ Case Rep. 2020 Feb 28;13(2):e232549. doi: 10.1136/bcr-2019-232549Crellin AJ, Musbahi O, Onwu N, et al. Appendiceal Crohn's disease: a rare differential of right iliac fossa pain. BMJ Case Rep. 2020 Feb 28;13(2):e232549. doi: 10.1136/bcr-2019-232549Тимербулатов В.М., Хавкин А.Ю., Резбаев А.Н., и соавт. Болезнь Крона червеобразного отростка. Хирургия. 1989;134–135.Timerbulatov V.M., Khavkin A.Yu., Rezbaev A.N., et al. Crohn's disease of the appendix. Surgery. 1989;134–135. (In Russ.).Vulkovic J, Cindro PV, Tomic S, et al. Signet Ring Carcinoma of the Appendix Presenting as Crohn`s Disease in a Young Male. Case Rep Gastroenterol. 2018;12:277–285. doi: 10.1159/000489288Vulkovic J, Cindro PV, Tomic S, et al. Signet Ring Carcinoma of the Appendix Presenting as Crohn`s Disease in a Young Male. Case Rep Gastroenterol. 2018;12:277–285. doi: 10.1159/000489288Rutledge RH, Alexander JW. Primary appendiceal malignancies: rare but important. Surgery. 1992;111(3):244–50.Rutledge RH, Alexander JW. Primary appendiceal malignancies: rare but important. Surgery. 1992;111(3):244–50.Katsuno G, Kagawa S, Kokudo Y, et al. Ureteral metastasis from appendiceal cancer: report of a case. Surg Today. 2005;35(2):168–53.Katsuno G, Kagawa S, Kokudo Y, et al. Ureteral metastasis from appendiceal cancer: report of a case. Surg Today. 2005;35(2):168–53.Pizarro TT, Michie MH, Bentz M, et al. IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells. J Immunol. 1999;162:6829–6835.Pizarro TT, Michie MH, Bentz M, et al. IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells. J Immunol. 1999;162:6829–6835.Shaffer VO, Wexner SD. Surgical management of Crohn's disease. Langenbecks Arch Surg. 2012;398:13–27.Shaffer VO, Wexner SD. Surgical management of Crohn's disease. Langenbecks Arch Surg. 2012;398:13–27.Borley NR, Mortensen NJ, Jewell DP, et al. The relationship between inflammatory and serosal connective tissue changes in ilealCrohn's disease: evidence for a possible causative link. J Pathol. 2000;190:196–202.Borley NR, Mortensen NJ, Jewell DP, et al. The relationship between inflammatory and serosal connective tissue changes in ilealCrohn's disease: evidence for a possible causative link. J Pathol. 2000;190:196–202.Shelley-Fraser G, Borley NR, Warren BF, et al. The connective tissue changes of Crohn's disease. Histopathology. 2012;60:1034–1044.Shelley-Fraser G, Borley NR, Warren BF, et al. The connective tissue changes of Crohn's disease. Histopathology. 2012;60:1034–1044.Culligan K, Coffey JC, Kiran RP, et al. The mesocolon: a prospective observational study. Colorectal Dis. 2012;14:421–428.Culligan K, Coffey JC, Kiran RP, et al. The mesocolon: a prospective observational study. Colorectal Dis. 2012;14:421–428.Сoffey JC, Dillon M, Sehgal R, et al. Mesenteric-based surgery exploits gastrointestinal, peritoneal, mesenteric and fascial continuity from duodenojejunal flexure to the anorectal junction: a review. Dig Surg. 2015;32:291–300.Сoffey JC, Dillon M, Sehgal R, et al. Mesenteric-based surgery exploits gastrointestinal, peritoneal, mesenteric and fascial continuity from duodenojejunal flexure to the anorectal junction: a review. Dig Surg. 2015;32:291–300.Coombes JL, Robinson NJ, Maloy KJ, et al. Regulatory T cells and intestinal homeostasis. Immunol Rev. 2005;204:184–194.Coombes JL, Robinson NJ, Maloy KJ, et al. Regulatory T cells and intestinal homeostasis. Immunol Rev. 2005;204:184–194.Schaffler A, Scholmerich J, Buchler C. Mechanisms of disease: adipocytokines and visceral adipose tissue–emerging role in intestinal and mesenteric diseases. Nat Clin Pract Gastroenterol Hepatol. 2005;2:103–111.Schaffler A, Scholmerich J, Buchler C. Mechanisms of disease: adipocytokines and visceral adipose tissue–emerging role in intestinal and mesenteric diseases. Nat Clin Pract Gastroenterol Hepatol. 2005;2:103–111.Wei B, Velazquez P, Turovskaya O, et al. Mesenteric B cells centrally inhibit CD4þ T cell colitis through interaction with regulatory T cell subsets. Proc Natl Acad Sci USA. 2005;102:2010–2015.Wei B, Velazquez P, Turovskaya O, et al. Mesenteric B cells centrally inhibit CD4þ T cell colitis through interaction with regulatory T cell subsets. Proc Natl Acad Sci USA. 2005;102:2010–2015.Fruhbeck G. Overview of adipose tissue and its role in obesity and metabolic disorders. Methods MolBiol. 2008;456:1–22.Fruhbeck G. Overview of adipose tissue and its role in obesity and metabolic disorders. Methods MolBiol. 2008;456:1–22.Sideri A, Bakirtzi K, Shih DQ, et al. Substance P mediates pro-inflammatory cytokine release form mesenteric adipocytes in inflammatory bowel disease patients. Cell Mol Gastroenterol Hepatol. 2015;1:420–432.Sideri A, Bakirtzi K, Shih DQ, et al. Substance P mediates pro-inflammatory cytokine release form mesenteric adipocytes in inflammatory bowel disease patients. Cell Mol Gastroenterol Hepatol. 2015;1:420–432.Le Dréan G, Haure-Mirande V, Ferrier L, et al. Visceral adipose tissue and leptin increase colonic epithelial tight junction permeability via a RhoA-ROCK-dependent pathway. FASEB J. 2014;28:1059–1070.Le Dréan G, Haure-Mirande V, Ferrier L, et al. Visceral adipose tissue and leptin increase colonic epithelial tight junction permeability via a RhoA-ROCK-dependent pathway. FASEB J. 2014;28:1059–1070.Coffey JC, O'Leaty DP, Kiernan MG, et al. The mesentery in Crohn's disease: friend or foe? Curr Opin Gastroenterol. 2016;32:267–273. doi: 10.1097/MOG.0000000000000280Coffey JC, O'Leaty DP, Kiernan MG, et al. The mesentery in Crohn's disease: friend or foe? Curr Opin Gastroenterol. 2016;32:267–273. doi: 10.1097/MOG.0000000000000280Li C, Kuemmerle JF. The mechanisms that mediate the development of fibrosis in patients with Crohn's Disease. Inflamm Bowel Dis. 2014;20:1250–1258.Li C, Kuemmerle JF. The mechanisms that mediate the development of fibrosis in patients with Crohn's Disease. Inflamm Bowel Dis. 2014;20:1250–1258.Zulian A, Cancello R, Micheletto G, et al. Visceral adipocytes: old actors in obesity and new protagonists in Crohn's disease? Gut. 2012;61:86–94.Zulian A, Cancello R, Micheletto G, et al. Visceral adipocytes: old actors in obesity and new protagonists in Crohn's disease? Gut. 2012;61:86–94.Burke JP, Mulsow JJ, O'Keane C, et al. Fibrogenesis in Crohn's Disease. Am J Gastroenterol. 2007;102:439–448.Burke JP, Mulsow JJ, O'Keane C, et al. Fibrogenesis in Crohn's Disease. Am J Gastroenterol. 2007;102:439–448.Sheehan AL, Warren BF, Gear MWL, et al. Fat-wrapping in Crohn's disease: pathological basis and relevance to surgical practice. Br J Surg. 1992;79:955–958.Sheehan AL, Warren BF, Gear MWL, et al. Fat-wrapping in Crohn's disease: pathological basis and relevance to surgical practice. Br J Surg. 1992;79:955–958.Peyrin-Biroulet L, Gonzalez F, Dubuquoy L, et al. Mesenteric fat as a source of C reactive protein and as a target for bacterial translocation in Crohn's disease. Gut. 2012;61:78–85.Peyrin-Biroulet L, Gonzalez F, Dubuquoy L, et al. Mesenteric fat as a source of C reactive protein and as a target for bacterial translocation in Crohn's disease. Gut. 2012;61:78–85.Sakamoto N, Nemoto Y, Masumoto K, et al. Crohn's disease with pathological findings of a granulomatous lesion in the appendix. J Pediatr Surg Case Rep. 2022, 76:102121.10.1016/j.epsc.2021.102121Sakamoto N, Nemoto Y, Masumoto K, et al. Crohn's disease with pathological findings of a granulomatous lesion in the appendix. J Pediatr Surg Case Rep. 2022, 76:102121.10.1016/j.epsc.2021.102121Mao R, Liao WD, He Y, et al. Computed tomographic enterography adds value to colonoscopy in differentiating Crohn's disease from intestinal tuberculosis: a potential diagnostic algorithm. Endoscopy. 2015;47:322–329.Mao R, Liao WD, He Y, et al. Computed tomographic enterography adds value to colonoscopy in differentiating Crohn's disease from intestinal tuberculosis: a potential diagnostic algorithm. Endoscopy. 2015;47:322–329.Li Y, Zhu W, Gong J, et al. Visceral fat area is associated with a high risk for early postoperative recurrence in Crohn's disease. Colorectal Dis. 2015;17:225–234.Li Y, Zhu W, Gong J, et al. Visceral fat area is associated with a high risk for early postoperative recurrence in Crohn's disease. Colorectal Dis. 2015;17:225–234.Chandra Sekar PK, Veerabathiran R. Genetics of Inflammatory Bowel Disease: Current Understanding and Future Directions. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2024;34(5):7–16. doi: 10.22416/1382-4376-2024-34-5-7-16Chandra Sekar PK, Veerabathiran R. Genetics of Inflammatory Bowel Disease: Current Understanding and Future Directions. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2024;34(5):7–16. doi: 10.22416/1382-4376-2024-34-5-7-16Hu S, UnikenVenema WT, Westra H-J, et al. Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease. Nature Communications. 2021;12(1). doi: 10.1038/s41467-021-21458-zHu S, UnikenVenema WT, Westra H-J, et al. Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease. Nature Communications. 2021;12(1). doi: 10.1038/s41467-021-21458-z

The authors declare that there are no conflicts of interest present.