gnckКолопроктологияKoloproktologia2073-75562686-7303Russian Association of Coloproctology10.33878/2073-7556-2024-23-2-143-150gnck-1829Research ArticleМЕТААНАЛИЗMETA-ANALYSISЭффективность хромоскопии с красителем и виртуальной хромоскопии в эндоскопической диагностике колит-ассоциированной дисплазии (систематический обзор и метаанализ)Chromoendoscopy and virtual chromoendoscopy for dysplasia screening in patients with ulcerative colitis (systematic review and meta-analysis)https://orcid.org/0000-0002-0544-0027АрхиповаО. В.ArkhipovaO. V.

Архипова Ольга Владиславовна 

ул. Саляма Адиля, д. 2, г. Москва, 123423, Россия 

 Olga V. Arkhipova 

 Salyama Adilya st., 2, Moscow, 123423, Russia 

olga2110.arhipova@yandex.ruhttps://orcid.org/0000-0001-5848-4050ЛикутовА. А.LikutovA. A.

 ул. Саляма Адиля, д. 2, г. Москва, 123423, Россия 

ул. Баррикадная, д. 2/1, г. Москва, 125993, Россия 

Salyama Adilya st., 2, Moscow, 123423, Russia 

Barrikadnaya st., 2/1-1, Moscow, 125993, Russia

https://orcid.org/0000-0001-7203-1859ПономаренкоА. А.PonomarenkoA. A.

 ул. Саляма Адиля, д. 2, г. Москва, 123423, Россия 

 Salyama Adilya st., 2, Moscow, 123423, Russia 

https://orcid.org/0000-0003-1697-4670ВыковаБ. А.VykovaB. A.

 ул. Саляма Адиля, д. 2, г. Москва, 123423, Россия 

 Salyama Adilya st., 2, Moscow, 123423, Russia 

ФГБУ «НМИЦ колопроктологии имени А.Н. Рыжих» Минздрава РоссииРоссияRyzhikh National Medical Research Center of ColoproctologyRussian FederationФГБУ «НМИЦ колопроктологии имени А.Н. Рыжих» Минздрава России; ФГБОУ ДПО РМАНПО Минздрава РоссииРоссияRyzhikh National Medical Research Center of Coloproctology; Russian Medical Academy of Continuous Professional EducationRussian Federation202421062024232143150Copyright © Архипова О.В., Ликутов А.А., Пономаренко А.А., Выкова Б.А., 20242024Архипова О.В., Ликутов А.А., Пономаренко А.А., Выкова Б.А.Arkhipova O.V., Likutov A.A., Ponomarenko A.A., Vykova B.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.ruproctology.com/jour/article/view/1829

ЦЕЛЬ: сравнить диагностическую информативность хромоскопии с применением красителя и виртуальной хромоскопии в выявлении колит-ассоциированной дисплазии.МАТЕРИАЛЫ И МЕТОДЫ: выполнен систематический обзор и метаанализ исследований, сравнивающих результаты применения хромоскопии с красителем и виртуальной хромоскопии для диагностики колит-ассоциированной дисплазии. Были оценены следующие показатели: частота встречаемости пациентов с эндоскопически выявленной колит-ассоциированной дисплазией и частота встречаемости колит-ассоциированной дисплазии среди общего количества выявленных изменений слизистой оболочки толстой кишки. Статистическая обработка данных при сравнении исследований, включенных в метаанализ, проводилась в программе Review Manager 5.3.РЕЗУЛЬТАТЫ: в систематический обзор литературы включено 4 исследования, суммарно анализирующих 364 пациента. В исследуемых группах не было установлено статистически значимых различий в частоте встречаемости пациентов с эндоскопически выявленной колит-ассоциированной дисплазией, а также в частоте встречаемости колит-ассоциированной дисплазии среди всех обнаруженных изменений слизистой оболочки толстой кишки (ОШ = 0,87; 95% ДИ 0,60–1,27; р = 0,47 и ОШ = 0,82; 95% ДИ 0,58–1,18; р = 0,29).ЗАКЛЮЧЕНИЕ: результаты проведенного метаанализа показывают, что виртуальная хромоскопия не уступает хромоскопии с применением красителя в выявлении колит-ассоциированной дисплазии. Однако в литературе отсутствуют данные, позволяющие провести оценку диагностической информативности этих двух эндоскопических методик, а также в полной мере оценить возможности виртуальной хромоскопии в диагностике колит-ассоциированной дисплазии. В связи с этим, очевидна необходимость в проведении дальнейших исследований для установления возможностей виртуальной хромоскопии.

AIM: to compare the diagnostic informativeness of mucosal dye spraying (chromoendoscopy) (CE) and virtual chromoendoscopy (VCE) in detecting dysplasia in patients with a long history ulcerative colitis (UC).MATERIALS AND METHODS: a systematic review and meta-analysis of studies comparing the results of the use of CE and VCE for the diagnosis of colitis-associated dysplasia was performed. The following indicators were evaluated: the frequency of patients with endoscopically detected colitis-associated dysplasia and the frequency of endoscopic diagnosis of colitis-associated dysplasia among the total number of identified lesions. The statistical analysis was carried out using the Review Manager software 5.3RESULTS: the systematic review included 4 studies, analyzing 364 patients in total. In the study groups, there were no statistical differences in patients with endoscopically detected colitis-associated dysplasia and in endoscopic diagnosis of colitis-associated dysplasia among total number of detected colorectal neoplasms (OR = 0.87; 95% CI 0.60–1.27; p = 0.47 and OR = 0.82; 95% CI 0.58–1.18; p = 0.29).CONCLUSION: meta-analysis could not demonstrate a significant difference between CE and VCE. However, additional studies are needed to recognize the role of VCE in the differentiation of neoplastic and non-neoplastic lesions in patients with UC

язвенный колитхромоэндоскопияколит-ассоциированная дисплазиявиртуальная хромоскопияulcerative colitischromoendoscopydysplasiavirtual chromoscopyReferencesНикулина И.В., Златкина А.Р., Белоусова Е.А., и соавт. Оценка клинико-эпидемиологических показателей воспалительных заболеваний кишечника в Московской области. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 1997;2:67–71Nikulina I.V., Zlatkina A.R., Belousova E.A., et al. Assessment of clinical and epidemiological indicators of inflammatory bowel diseases in the Moscow region. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 1997;2:67–71. (In Russ.).Николаева Н.Н., и соавт. Эпидемиология язвенного колита и болезни Крона в Красноярском крае. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2004;14(5):133Nikolaeva N.N., et al. Epidemiology of ulcerative colitis and Crohn’s disease in the Krasnoyarsk region. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2004;14(5):133. (In Russ.).Rutter MD, Saunders BP, Wilkinson KH, et al. Thirty-year analysis of a colonoscopic surveillance program for neoplasia in ulcerative colitis. Gastroenterology.2006;130:1030–1038. doi: 10.1053/j.gastro.2005.12.035Rutter MD, Saunders BP, Wilkinson KH, et al. Thirty-year analysis of a colonoscopic surveillance program for neoplasia in ulcerative colitis. Gastroenterology.2006;130:1030–1038. doi: 10.1053/j.gastro.2005.12.035Eaden JA, Abrams KR, Mayberry JF. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut 2001;48:526 — 535. doi: 10.1136/gut.48.4.526Eaden JA, Abrams KR, Mayberry JF. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut 2001;48:526 — 535. doi: 10.1136/gut.48.4.526Magro F, et al. European consensus on the histopathology of inflammatory bowel disease. Journal of Crohn’s and Colitis. 2013;7:827–851. doi: 10.1016/j.crohns.2013.06.001Magro F, et al. European consensus on the histopathology of inflammatory bowel disease. Journal of Crohn’s and Colitis. 2013;7:827–851. doi: 10.1016/j.crohns.2013.06.001Lu X, et al. p53 expression in patients with ulcerative colitis — associated with dysplasia and carcinoma: a systematic meta-analysis. Gastroenterology.2017;17:111. doi: 10.1186/s12876-017-0665-yLu X, et al. p53 expression in patients with ulcerative colitis — associated with dysplasia and carcinoma: a systematic meta-analysis. Gastroenterology.2017;17:111. doi: 10.1186/s12876-017-0665-yШелыгин Ю.А., Ивашкин В.Т., Белоусова Е.А., и соавт. Язвенный колит (К51), взрослые. Колопроктология.2023;22(1):10–44. doi: 10.33878/2073-7556-2023-22-1-10-44Shelygin Y.A., Ivashkin V.T., Belousova E.A., et al. Ulcerative colitis (K51), adults. Koloproktologia. 2023;22(1):10–44. (In Russ.) doi: 10.33878/2073-7556-2023-22-1-10-44Rubin DT, Ananthakrishnan AN, Siegel CA, et al. ACG Clinical Guideline: Ulcerative Colitis in Adults. Am J Gastroenterol. 2019 Mar;114(3):384–413. doi: 10.14309/ajg.0000000000000152Rubin DT, Ananthakrishnan AN, Siegel CA, et al. ACG Clinical Guideline: Ulcerative Colitis in Adults. Am J Gastroenterol. 2019 Mar;114(3):384–413. doi: 10.14309/ajg.0000000000000152Laine L, Kaltenbach T, Barkun A, et al. SCENIC Guideline Development Panel. SCENIC international consensus statement on surveillance and management of dysplasia in inflammatory bowel disease. Gastroenterology. 2015;148(3):639–651.e28. doi: 10.1053/j.gastro.2015.01.031Laine L, Kaltenbach T, Barkun A, et al. SCENIC Guideline Development Panel. SCENIC international consensus statement on surveillance and management of dysplasia in inflammatory bowel disease. Gastroenterology. 2015;148(3):639–651.e28. doi: 10.1053/j.gastro.2015.01.031Maaser C, Sturm A, et al. ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detection of complications. Journal of Crohn’s and Colitis. 2019;13(2):144–164. doi: 10.1093/ecco-jcc/jjy113Maaser C, Sturm A, et al. ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detection of complications. Journal of Crohn’s and Colitis. 2019;13(2):144–164. doi: 10.1093/ecco-jcc/jjy113Bisschops R, East JE, Hassan C, et al. Advanced imaging for detection and differentiation of colorectal neoplasia: European Society of Gastrointestinal Endoscopy (ESGE) Guideline — Update 2019. Endoscopy. 2019;51(12):1155–1179. doi: 10.1055/a-1031-7657 Epub 2019 Nov 11. Erratum in: Endoscopy. 2019 Dec;51(12):C6. PMID: 31711241.Bisschops R, East JE, Hassan C, et al. Advanced imaging for detection and differentiation of colorectal neoplasia: European Society of Gastrointestinal Endoscopy (ESGE) Guideline — Update 2019. Endoscopy. 2019;51(12):1155–1179. doi: 10.1055/a-1031-7657 Epub 2019 Nov 11. Erratum in: Endoscopy. 2019 Dec;51(12):C6. PMID: 31711241.Iannone A, Ruospo M, Wong G, et al. Chromoendoscopy for Surveillance in Ulcerative Colitis and Crohn’s Disease: A Systematic Review of Randomized Trials. Clin Gastroenterol Hepatol. 2017;15(11):1684–1697.e11. doi: 10.1016/j.cgh.2016.11.021Iannone A, Ruospo M, Wong G, et al. Chromoendoscopy for Surveillance in Ulcerative Colitis and Crohn’s Disease: A Systematic Review of Randomized Trials. Clin Gastroenterol Hepatol. 2017;15(11):1684–1697.e11. doi: 10.1016/j.cgh.2016.11.021Marion JF, Waye JD, Present DH, et al. Chromoendoscopytargeted biopsies are superior to standard colonoscopic surveillance for detecting dysplasia in inflammatory bowel disease patients: a prospective endoscopic trial. Am J Gastroenterol. 2008;103:2342 — 2349. doi: 10.1111/j.1572-0241.2008.01934.xMarion JF, Waye JD, Present DH, et al. Chromoendoscopytargeted biopsies are superior to standard colonoscopic surveillance for detecting dysplasia in inflammatory bowel disease patients: a prospective endoscopic trial. Am J Gastroenterol. 2008;103:2342 — 2349. doi: 10.1111/j.1572-0241.2008.01934.xMarion JF, Waye JD, Israel Y, et al. Chromoendoscopy is more effective than standard colonoscopy in detecting dysplasia during long-term surveillance of patients with colitis. Clin Gastroenterol Hepatol. 2016;14:713–719. doi: 10.1016/j.cgh.2015.11.011 Epub 2015 Dec 2.Marion JF, Waye JD, Israel Y, et al. Chromoendoscopy is more effective than standard colonoscopy in detecting dysplasia during long-term surveillance of patients with colitis. Clin Gastroenterol Hepatol. 2016;14:713–719. doi: 10.1016/j.cgh.2015.11.011 Epub 2015 Dec 2.Brooker JC, Saunders BP, Shah SG, et al. Total colonic dyespray increases the detection of diminutive adenomas during routine colonoscopy: a randomized controlled trial. Gastrointest Endosc.2002;56:333 — 338. doi: 10.1016/s0016-5107(02)70034-5Brooker JC, Saunders BP, Shah SG, et al. Total colonic dyespray increases the detection of diminutive adenomas during routine colonoscopy: a randomized controlled trial. Gastrointest Endosc.2002;56:333 — 338. doi: 10.1016/s0016-5107(02)70034-5Le Rhun M, Coron E, Parlier D, et al. High resolution colonoscopy with chromoscopy versus standard colonoscopy for the detection of colonic neoplasia: a randomized study. Clin Gastroenterol Hepatol. 2006;4:349–354. doi: 10.1016/j.cgh.2005.12.009Le Rhun M, Coron E, Parlier D, et al. High resolution colonoscopy with chromoscopy versus standard colonoscopy for the detection of colonic neoplasia: a randomized study. Clin Gastroenterol Hepatol. 2006;4:349–354. doi: 10.1016/j.cgh.2005.12.009Bisschops R, et al. Pit pattern analysis with high-definition chromoendoscopy and narrow-band imaging for optical diagnosis of dysplasia in patients with ulcerative colitis. Gastrointestinal Endoscopy.2017;86:1100–1106. doi: 10.1016/j.gie.2017.09.024Bisschops R, et al. Pit pattern analysis with high-definition chromoendoscopy and narrow-band imaging for optical diagnosis of dysplasia in patients with ulcerative colitis. Gastrointestinal Endoscopy.2017;86:1100–1106. doi: 10.1016/j.gie.2017.09.024Bisschops R, et al. Chromoendoscopy versus narrow band imaging in UC: A prospective randomised controlled trial. Gut. BMJ Group. 2018;67(6):1087–1094. doi: 10.1136/gutjnl-2016-313213Bisschops R, et al. Chromoendoscopy versus narrow band imaging in UC: A prospective randomised controlled trial. Gut. BMJ Group. 2018;67(6):1087–1094. doi: 10.1136/gutjnl-2016-313213Pellisé M, et al. Narrow-band imaging as an alternative to chromoendoscopy for the detection of dysplasia in long-standing inflammatory bowel disease: a prospective, randomized, crossover study. Gastrointestinal Endoscopy. 2011;74(4):840–848. doi: 10.1016/j.gie.2011.05.013Pellisé M, et al. Narrow-band imaging as an alternative to chromoendoscopy for the detection of dysplasia in long-standing inflammatory bowel disease: a prospective, randomized, crossover study. Gastrointestinal Endoscopy. 2011;74(4):840–848. doi: 10.1016/j.gie.2011.05.013WHO Classification of Tumours, 5th Edition, Volume 1. WHO Classification of Tumours Editorial Board, 2019. ISBN-13WHO Classification of Tumours, 5th Edition, Volume 1. WHO Classification of Tumours Editorial Board, 2019. ISBN-13González-Bernardo O, Riestra S, Vivas S, et al. Chromoendoscopy With Indigo Carmine vs Virtual Chromoendoscopy (iSCAN 1) for Neoplasia Screening in Patients With Inflammatory Bowel Disease: A Prospective Randomized Study. Inflamm Bowel Dis. 2021;27(8):1256–1262. doi: 10.1093/ibd/izaa291González-Bernardo O, Riestra S, Vivas S, et al. Chromoendoscopy With Indigo Carmine vs Virtual Chromoendoscopy (iSCAN 1) for Neoplasia Screening in Patients With Inflammatory Bowel Disease: A Prospective Randomized Study. Inflamm Bowel Dis. 2021;27(8):1256–1262. doi: 10.1093/ibd/izaa291Efthymiou M, et al. Chromoendoscopy versus narrow band imaging for colonic surveillance in inflammatory bowel disease. Inflammation Bowel Diseases.2013;19(10):2132–2138. doi: 10.1097/MIB.0b013e31829637b9Efthymiou M, et al. Chromoendoscopy versus narrow band imaging for colonic surveillance in inflammatory bowel disease. Inflammation Bowel Diseases.2013;19(10):2132–2138. doi: 10.1097/MIB.0b013e31829637b9Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanations and elaboration. BMJ [Internet]. 2009;339:2700. doi: 10.1136/bmj.b2700Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanations and elaboration. BMJ [Internet]. 2009;339:2700. doi: 10.1136/bmj.b2700Higgins JP, Altman DР, Gøtzsche PC, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. Br. Med. J. 2011;343:889–893. doi: 10.1136/bmj.d5928Higgins JP, Altman DР, Gøtzsche PC, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. Br. Med. J. 2011;343:889–893. doi: 10.1136/bmj.d5928Lo CK, Mertz D, Loeb M. Newcastle-Ottawa Scale: comparing reviewers’ to authors’ assessments. BMC Med Res Methodol. 2014;14:45. doi: 10.1186/1471-2288-14-45Lo CK, Mertz D, Loeb M. Newcastle-Ottawa Scale: comparing reviewers’ to authors’ assessments. BMC Med Res Methodol. 2014;14:45. doi: 10.1186/1471-2288-14-45Kudo S, et al. Diagnosis of colorectal tumorous lesions by magnifying endoscopy. Gastrointestinal Endoscopy.1996;44:8–14. doi: 10.1016/s0016-5107(96)70222Kudo S, et al. Diagnosis of colorectal tumorous lesions by magnifying endoscopy. Gastrointestinal Endoscopy.1996;44:8–14. doi: 10.1016/s0016-5107(96)70222Hurlstone DP, Sanders DS, Lobo AJ, et al. Indigo carmine-assisted high magnification chromoscopic colonoscopy for the detection and characterization of intraepithelial neoplasia in ulcerative colitis: a prospective evaluation. Endoscopy. 2005;37:1186–1192. doi: 10.1055/s-2005-921032Hurlstone DP, Sanders DS, Lobo AJ, et al. Indigo carmine-assisted high magnification chromoscopic colonoscopy for the detection and characterization of intraepithelial neoplasia in ulcerative colitis: a prospective evaluation. Endoscopy. 2005;37:1186–1192. doi: 10.1055/s-2005-921032Kiesslich R, Fritsch J, Holtmann M, et al. Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer inulcerative colitis. Gastroenterology. 2003;124:880 — 888. doi: 10.1053/gast.2003.50146Kiesslich R, Fritsch J, Holtmann M, et al. Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer inulcerative colitis. Gastroenterology. 2003;124:880 — 888. doi: 10.1053/gast.2003.50146Sano Y, et al. Meshed capillary vessels by use of narrowband imaging for differential diagnosis of small colorectal polyps. Gastrointestinal Endoscopy.2009;69(2):278–283. doi: 10.1016/j.gie.2008.04.066Sano Y, et al. Meshed capillary vessels by use of narrowband imaging for differential diagnosis of small colorectal polyps. Gastrointestinal Endoscopy.2009;69(2):278–283. doi: 10.1016/j.gie.2008.04.066Sano Y, Tanaka S, Kudo SE, et al. Narrow-band imaging (NBI) magnifying endoscopic classification of colorectal tumors proposed by the Japan NBI Expert Team. Dig Endosc. 2016 ;28(5):526–533. doi: 10.1111/den.12644 Epub 2016. PMID: 26927367.Sano Y, Tanaka S, Kudo SE, et al. Narrow-band imaging (NBI) magnifying endoscopic classification of colorectal tumors proposed by the Japan NBI Expert Team. Dig Endosc. 2016 ;28(5):526–533. doi: 10.1111/den.12644 Epub 2016. PMID: 26927367.Kawasaki K, Nakamura S, Esaki M, et al. Clinical usefulness of magnifying colonoscopy for the diagnosis of ulcerative colitisassociated neoplasia. Dig Endosc.2019;31(1):36–42. doi: 10.1111/den.13382 PMID: 30994234.Kawasaki K, Nakamura S, Esaki M, et al. Clinical usefulness of magnifying colonoscopy for the diagnosis of ulcerative colitisassociated neoplasia. Dig Endosc.2019;31(1):36–42. doi: 10.1111/den.13382 PMID: 30994234.

The authors declare that there are no conflicts of interest present.