<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gnck</journal-id><journal-title-group><journal-title xml:lang="ru">Колопроктология</journal-title><trans-title-group xml:lang="en"><trans-title>Koloproktologia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-7556</issn><issn pub-type="epub">2686-7303</issn><publisher><publisher-name>Russian Association of Coloproctology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33878/2073-7556-2023-22-1-147-159</article-id><article-id custom-type="elpub" pub-id-type="custom">gnck-1785</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ И МЕТААНАЛИЗ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERATURE REVIEWS AND METAANALYSIS</subject></subj-group></article-categories><title-group><article-title>Лекарственная терапия воспалительных заболеваний кишечника у беременных. Обзор актуальных данных по безопасности и эффективности</article-title><trans-title-group xml:lang="en"><trans-title>Conservative treatment of inflammatory bowel diseases during pregnancy. Review of current safety and efficacy data</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5714-3462</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Успенская</surname><given-names>Ю. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Uspenskaya</surname><given-names>Yu. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Успенская Юлия Борисовна — доктор медицинских наук, ведущий гастроэнтеролог </p><p>Столярный пер., д.3, г.Москва, 123022</p></bio><bio xml:lang="en"><p>Yulia B. Uspenskaya</p><p>Stolyarnyy lane, 3, Moscow, 123022</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1697-4670</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нанаева</surname><given-names>Б. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Nanaeva</surname><given-names>B. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нанаева Бэлла Александровна — кандидат медицинских наук, заведующая гастроэнтерологическим отделением </p><p>ул. Саляма Адиля, д.2, г.Москва, 123423</p></bio><bio xml:lang="en"><p>Bella A. Nanaeva</p><p>Salyama Adilya str., 2, Moscow, 123423</p></bio><email xlink:type="simple">nanaeva_ba@gnck.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3146-0400</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Олейник</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Oleynik</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Олейник Виктория Андреевна — младший научный сотрудник отдела по изучению воспалительных и функциональных заболеваний кишечника </p><p>ул. Саляма Адиля, д.2, г.Москва, 123423</p></bio><bio xml:lang="en"><p>Victoria A. Oleynik</p><p>Salyama Adilya str., 2, Moscow, 123423</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ООО «Медсанчасть №14» (клиника Рассвет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>LLC «Medical Unit № 14» (Сlinic «Rassvet»)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ «НМИЦ колопроктологии имени А.Н. Рыжих» Минздрава России</institution><country>Russian Federation</country></aff><aff xml:lang="en"><institution>Ryzhikh National Medical Research Center of Coloproctology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>21</day><month>03</month><year>2023</year></pub-date><volume>22</volume><issue>1</issue><fpage>147</fpage><lpage>159</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Успенская Ю.Б., Нанаева Б.А., Олейник В.А., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Успенская Ю.Б., Нанаева Б.А., Олейник В.А.</copyright-holder><copyright-holder xml:lang="en">Uspenskaya Y.B., Nanaeva B.A., Oleynik V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ruproctology.com/jour/article/view/1785">https://www.ruproctology.com/jour/article/view/1785</self-uri><abstract><p>Пик заболеваемости язвенным колитом (ЯК) и болезнью Крона (БК) во всем мире приходится на детородный возраст. Высокая активность воспалительных заболеваний кишечника (ВЗК) во время беременности является фактором риска развития акушерских осложнений, в связи с чем необходим контроль над течением заболеваний. Из-за недостатка информации о безопасности лекарственная терапия часто необоснованно отменяется во время беременности. В публикации приводятся современные данные о безопасности у беременных базовой и таргетной терапии ЯК и БК.</p></abstract><trans-abstract xml:lang="en"><p>The incidence of ulcerative colitis (UC) and Crohn’s disease (CD) worldwide falls on the childbearing age. High activity of inflammatory bowel diseases (IBD) during pregnancy is a risk factor for the development of obstetric complications, and therefore it is necessary to control the course of diseases. Due to the lack of safety information, drug therapy is often unreasonably canceled during pregnancy. The publication provides up-to-date on the safety of basic and targeted therapy of UC and CD in pregnant.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>язвенный колит</kwd><kwd>болезнь Крона</kwd><kwd>воспалительные заболевания кишечника</kwd><kwd>беременность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ulcerative colitis</kwd><kwd>Crohn’s disease</kwd><kwd>inflammatory bowel diseases</kwd><kwd>pregnancy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kaplan GG, Windsor JW. The four epidemiological stages in the global evolution of inflammatory bowel disease. Nat Rev Gastroenterol Hepatol. 2021 Jan;18(1):56–66. Epub 2020 Oct 8. PMID: 33033392; PMCID: PMC7542092. doi: 10.1038/s41575-020-00360-x</mixed-citation><mixed-citation xml:lang="en">Kaplan GG, Windsor JW. The four epidemiological stages in the global evolution of inflammatory bowel disease. Nat Rev Gastroenterol Hepatol. 2021 Jan;18(1):56–66. Epub 2020 Oct 8. PMID: 33033392; PMCID: PMC7542092. doi: 10.1038/s41575-020-00360-x</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Molodecky NA, Soon IS, Rabi DM, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology. 2012 Jan;142(1):46–54. e42; quiz e30. Epub 2011 Oct 14. PMID: 22001864. doi: 10.1053/j.gastro.2011.10.001</mixed-citation><mixed-citation xml:lang="en">Molodecky NA, Soon IS, Rabi DM, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology. 2012 Jan;142(1):46–54. e42; quiz e30. Epub 2011 Oct 14. PMID: 22001864. doi: 10.1053/j.gastro.2011.10.001</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Pedersen N, Bortoli A, Duricova D, et al. European Crohn-Colitis Organisation-ECCO-Study Group of Epidemiology Committee-EpiCom. The course of inflammatory bowel disease during pregnancy and postpartum: a prospective European ECCO-EpiCom Study of 209 pregnant women. Aliment Pharmacol Ther. 2013 Sep;38(5):501–12. Epub 2013 Jul 15. PMID: 23855425. doi: 10.1111/apt.12412</mixed-citation><mixed-citation xml:lang="en">Pedersen N, Bortoli A, Duricova D, et al. European Crohn-Colitis Organisation-ECCO-Study Group of Epidemiology Committee-EpiCom. The course of inflammatory bowel disease during pregnancy and postpartum: a prospective European ECCO-EpiCom Study of 209 pregnant women. Aliment Pharmacol Ther. 2013 Sep;38(5):501–12. Epub 2013 Jul 15. PMID: 23855425. doi: 10.1111/apt.12412</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Dickson I. Pregnancy safe and beneficial for women with IBD. Nat Rev Gastroenterol Hepatol. 2019;16(8):454.</mixed-citation><mixed-citation xml:lang="en">Dickson I. Pregnancy safe and beneficial for women with IBD. Nat Rev Gastroenterol Hepatol. 2019;16(8):454.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Eisfeld H, Glimm AM, Burmester GR, et al. Pregnancy outcome in women with different rheumatic diseases: a retrospective analysis. Scand J Rheumatol. 2021 Jul;50(4):299–306. Epub 2021 Feb 24. PMID: 33622159. doi: 10.1080/03009742.2020.1849788</mixed-citation><mixed-citation xml:lang="en">Eisfeld H, Glimm AM, Burmester GR, et al. Pregnancy outcome in women with different rheumatic diseases: a retrospective analysis. Scand J Rheumatol. 2021 Jul;50(4):299–306. Epub 2021 Feb 24. PMID: 33622159. doi: 10.1080/03009742.2020.1849788</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Molnár T, Farkas K, Nagy F, et al. Pregnancy outcome in patients with inflammatory bowel disease according to the activity of the disease and the medical treatment: a case-control study. Scand J Gastroenterol. 2010;45(11), 1302-1306.</mixed-citation><mixed-citation xml:lang="en">Molnár T, Farkas K, Nagy F, et al. Pregnancy outcome in patients with inflammatory bowel disease according to the activity of the disease and the medical treatment: a case-control study. Scand J Gastroenterol. 2010;45(11), 1302-1306.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Sachs HC; Committee On Drugs. The transfer of drugs and therapeutics into human breast milk: an update on selected topics. Pediatrics. 2013 Sep;132(3):e796-809. Epub 2013 Aug 26. PMID: 23979084. doi: 10.1542/peds.2013-1985</mixed-citation><mixed-citation xml:lang="en">Sachs HC; Committee On Drugs. The transfer of drugs and therapeutics into human breast milk: an update on selected topics. Pediatrics. 2013 Sep;132(3):e796-809. Epub 2013 Aug 26. PMID: 23979084. doi: 10.1542/peds.2013-1985</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">McConnell RA, Mahadevan U. Pregnancy and the Patient with Inflammatory Bowel Disease: Fertility, Treatment, Delivery, and Complications. Gastroenterol Clin North Am. 2016 Jun;45(2):285– 301. PMID: 27261899. doi: 10.1016/j.gtc.2016.02.006</mixed-citation><mixed-citation xml:lang="en">McConnell RA, Mahadevan U. Pregnancy and the Patient with Inflammatory Bowel Disease: Fertility, Treatment, Delivery, and Complications. Gastroenterol Clin North Am. 2016 Jun;45(2):285– 301. PMID: 27261899. doi: 10.1016/j.gtc.2016.02.006</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Mahadevan U, Robinson C, Bernasko N, et al. Inflammatory Bowel Disease in Pregnancy Clinical Care Pathway: A Report From the American Gastroenterological Association IBD Parenthood Project Working Group. Gastroenterology. 2019 Apr;156(5):1508–1524. Epub 2019 Jan 16. PMID: 30658060. doi: 10.1053/j.gastro.2018.12.022</mixed-citation><mixed-citation xml:lang="en">Mahadevan U, Robinson C, Bernasko N, et al. Inflammatory Bowel Disease in Pregnancy Clinical Care Pathway: A Report From the American Gastroenterological Association IBD Parenthood Project Working Group. Gastroenterology. 2019 Apr;156(5):1508–1524. Epub 2019 Jan 16. PMID: 30658060. doi: 10.1053/j.gastro.2018.12.022</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Nielsen OH, Gubatan JM, Juhl CB, et al. Biologics for inflammatory bowel disease and their safety in pregnancy: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2020;20:74–87.</mixed-citation><mixed-citation xml:lang="en">Nielsen OH, Gubatan JM, Juhl CB, et al. Biologics for inflammatory bowel disease and their safety in pregnancy: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2020;20:74–87.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Lee HH, Bae JM, Lee BI, et al. Pregnancy outcomes in women with inflammatory bowel disease: a 10-year nationwide population-based cohort study. Aliment Pharmacol Ther. 2020 May;51(9):861–869. Epub 2020 Apr 7. PMID: 32266739. doi: 10.1111/apt.15654</mixed-citation><mixed-citation xml:lang="en">Lee HH, Bae JM, Lee BI, et al. Pregnancy outcomes in women with inflammatory bowel disease: a 10-year nationwide population-based cohort study. Aliment Pharmacol Ther. 2020 May;51(9):861–869. Epub 2020 Apr 7. PMID: 32266739. doi: 10.1111/apt.15654</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Rottenstreich A, Fridman Lev S, Rotem R, et al. Disease flare at prior pregnancy and disease activity at conception are important determinants of disease relapse at subsequent pregnancy in women with inflammatory bowel diseases. Arch Gynecol Obstet. 2020 Jun;301(6):1449–1454. Epub 2020 May 6. PMID: 32377786. doi: 10.1007/s00404-020-05557-8</mixed-citation><mixed-citation xml:lang="en">Rottenstreich A, Fridman Lev S, Rotem R, et al. Disease flare at prior pregnancy and disease activity at conception are important determinants of disease relapse at subsequent pregnancy in women with inflammatory bowel diseases. Arch Gynecol Obstet. 2020 Jun;301(6):1449–1454. Epub 2020 May 6. PMID: 32377786. doi: 10.1007/s00404-020-05557-8</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Laube R, Paramsothy S, Leong RW. Use of medications during pregnancy and breastfeeding for Crohn’s disease and ulcerative colitis. Expert Opin Drug Saf. 2021 Mar;20(3):275–292. Epub 2021 Feb 5. PMID: 33412078. doi: 10.1080/14740338.2021.1873948</mixed-citation><mixed-citation xml:lang="en">Laube R, Paramsothy S, Leong RW. Use of medications during pregnancy and breastfeeding for Crohn’s disease and ulcerative colitis. Expert Opin Drug Saf. 2021 Mar;20(3):275–292. Epub 2021 Feb 5. PMID: 33412078. doi: 10.1080/14740338.2021.1873948</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Walldorf J, Pijan E, Greinert R, et al. Family planning with inflammatory bowel disease: the challenge of childlessness and parent concerns. Z Gastroenterol. 2021 Aug;59(8):841–850. Epub 2021 Mar 18. PMID: 33735917. doi: 10.1055/a-1404-3610</mixed-citation><mixed-citation xml:lang="en">Walldorf J, Pijan E, Greinert R, et al. Family planning with inflammatory bowel disease: the challenge of childlessness and parent concerns. Z Gastroenterol. 2021 Aug;59(8):841–850. Epub 2021 Mar 18. PMID: 33735917. doi: 10.1055/a-1404-3610</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Rahimi R, Nikfar S, Rezaie A, et al. Pregnancy outcome in women with inflammatory bowel disease following exposure to 5-aminosalicylic acid drugs: a meta-analysis. Reprod Toxicol. 2008;25:271–275.</mixed-citation><mixed-citation xml:lang="en">Rahimi R, Nikfar S, Rezaie A, et al. Pregnancy outcome in women with inflammatory bowel disease following exposure to 5-aminosalicylic acid drugs: a meta-analysis. Reprod Toxicol. 2008;25:271–275.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Hernandez-Diaz S, Mitchell AA, Kelley KE, et al. Medications as a potential source of exposure to phthalates in the U.S. population. Environ Health Perspect. 2009;117:185–189.</mixed-citation><mixed-citation xml:lang="en">Hernandez-Diaz S, Mitchell AA, Kelley KE, et al. Medications as a potential source of exposure to phthalates in the U.S. population. Environ Health Perspect. 2009;117:185–189.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Jurewicz J, Hanke W. Exposure to phthalates: reproductive outcome and children health. A review of epidemiological studies. Int J Occup Med Environ Health. 2011;24:115–141.</mixed-citation><mixed-citation xml:lang="en">Jurewicz J, Hanke W. Exposure to phthalates: reproductive outcome and children health. A review of epidemiological studies. Int J Occup Med Environ Health. 2011;24:115–141.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Singh A, Martin CF, Kane SV, et al. Is asacol use associated with congenital anomalies? Results from a nationwide prospective pregnancy registry: su1030. Gastroenterology. 2013;144. doi: 10.1053/j.gastro.2012.10.005</mixed-citation><mixed-citation xml:lang="en">Singh A, Martin CF, Kane SV, et al. Is asacol use associated with congenital anomalies? Results from a nationwide prospective pregnancy registry: su1030. Gastroenterology. 2013;144. doi: 10.1053/j.gastro.2012.10.005</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Baggott J, Morgan S, Ha T, et al. Inhibition of folate-dependent enzymes by non-steroidal anti-inflammatory drugs. Biochem J. 1992;282:197–202.</mixed-citation><mixed-citation xml:lang="en">Baggott J, Morgan S, Ha T, et al. Inhibition of folate-dependent enzymes by non-steroidal anti-inflammatory drugs. Biochem J. 1992;282:197–202.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Shannahan SE, Erlich JM, Peppercorn MA. Insights into the treatment of inflammatory bowel disease in pregnancy. Therap Adv Gastroenterol. 2019;12:175628481985223.</mixed-citation><mixed-citation xml:lang="en">Shannahan SE, Erlich JM, Peppercorn MA. Insights into the treatment of inflammatory bowel disease in pregnancy. Therap Adv Gastroenterol. 2019;12:175628481985223.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Hviid A, Molgaard-Nielsen D. Corticosteroid use during pregnancy and risk of orofacial clefts. CMAJ. 2011;183:796–804.</mixed-citation><mixed-citation xml:lang="en">Hviid A, Molgaard-Nielsen D. Corticosteroid use during pregnancy and risk of orofacial clefts. CMAJ. 2011;183:796–804.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Leung YP, Kaplan GG, Coward S, et al. Intrapartum corticosteroid use significantly increases the risk of gestational diabetes in women with inflammatory bowel disease. J Crohns Colitis. 2015;9:223–230.</mixed-citation><mixed-citation xml:lang="en">Leung YP, Kaplan GG, Coward S, et al. Intrapartum corticosteroid use significantly increases the risk of gestational diabetes in women with inflammatory bowel disease. J Crohns Colitis. 2015;9:223–230.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Lin K, Martin CF, Dassopoulos T, et al. Pregnancy outcomes amongst mothers with inflammatory bowel disease exposed to systemic corticosteroids: results of the PIANO registry. Gastroenterology. 2014;146:S1.</mixed-citation><mixed-citation xml:lang="en">Lin K, Martin CF, Dassopoulos T, et al. Pregnancy outcomes amongst mothers with inflammatory bowel disease exposed to systemic corticosteroids: results of the PIANO registry. Gastroenterology. 2014;146:S1.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Truta B, Althumairi A, Canner J, et al. Potential risks of immunosuppressant drugs to the pregnant patient. Am J Gastroenterol. 2015;110:S966.</mixed-citation><mixed-citation xml:lang="en">Truta B, Althumairi A, Canner J, et al. Potential risks of immunosuppressant drugs to the pregnant patient. Am J Gastroenterol. 2015;110:S966.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Fedorak RN, Bistritz L. Targeted delivery, safety, and efficacy of oral enteric-coated formulations of budesonide. Adv Drug Deliv Rev. 2005;57:303–316.</mixed-citation><mixed-citation xml:lang="en">Fedorak RN, Bistritz L. Targeted delivery, safety, and efficacy of oral enteric-coated formulations of budesonide. Adv Drug Deliv Rev. 2005;57:303–316.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Beaulieu DB, Ananthakrishnan AN, Issa M, et al. Budesonide induction and maintenance therapy for Crohn’s disease during pregnancy. Inflamm Bowel Dis. 2009 Jan;15(1):25–8. PMID: 18680195. doi: 10.1002/ibd.20640</mixed-citation><mixed-citation xml:lang="en">Beaulieu DB, Ananthakrishnan AN, Issa M, et al. Budesonide induction and maintenance therapy for Crohn’s disease during pregnancy. Inflamm Bowel Dis. 2009 Jan;15(1):25–8. PMID: 18680195. doi: 10.1002/ibd.20640</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Rahim MN, Ran S, Shah S, et al. Safety and Efficacy of Budesonide During Pregnancy in Women With Autoimmune Hepatitis. Hepatology. 2021 Jun;73(6):2601–2606. Epub 2021 May 24. PMID: 33188708. doi: 10.1002/hep.31634</mixed-citation><mixed-citation xml:lang="en">Rahim MN, Ran S, Shah S, et al. Safety and Efficacy of Budesonide During Pregnancy in Women With Autoimmune Hepatitis. Hepatology. 2021 Jun;73(6):2601–2606. Epub 2021 May 24. PMID: 33188708. doi: 10.1002/hep.31634</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">van der Woude CJ, Ardizzone S, Bengtson MB, et al. ECCO: The Second European Evidenced-Based Consensus on Reproduction and Pregnancy in Inflammatory Bowel Disease. 2018. https://gastropregnancy.com/spetsialistam/2-j-konsensus-ecco-po-reproduktivnomu-zdorovyu-zhenshhin-s-vzk</mixed-citation><mixed-citation xml:lang="en">van der Woude CJ, Ardizzone S, Bengtson MB, et al. ECCO: The Second European Evidenced-Based Consensus on Reproduction and Pregnancy in Inflammatory Bowel Disease. 2018. https://gastropregnancy.com/spetsialistam/2-j-konsensus-ecco-po-reproduktivnomu-zdorovyu-zhenshhin-s-vzk</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Nguyen GC, Seow CH, Maxwell C, et al. IBD in Pregnancy Consensus Group; Canadian Association of Gastroenterology. The Toronto Consensus Statements for the Management of Inflammatory Bowel Disease in Pregnancy. Gastroenterology. 2016 Mar;150(3):734– 757.e1. Epub 2015 Dec 11. PMID: 26688268. doi: 10.1053/j.gastro.2015.12.003</mixed-citation><mixed-citation xml:lang="en">Nguyen GC, Seow CH, Maxwell C, et al. IBD in Pregnancy Consensus Group; Canadian Association of Gastroenterology. The Toronto Consensus Statements for the Management of Inflammatory Bowel Disease in Pregnancy. Gastroenterology. 2016 Mar;150(3):734– 757.e1. Epub 2015 Dec 11. PMID: 26688268. doi: 10.1053/j.gastro.2015.12.003</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Cleary BJ, Kallen B. Early pregnancy azathioprine use and pregnancy outcomes. Birth Defects Res A Clin Mol Teratol. 2009;85:647– 654.</mixed-citation><mixed-citation xml:lang="en">Cleary BJ, Kallen B. Early pregnancy azathioprine use and pregnancy outcomes. Birth Defects Res A Clin Mol Teratol. 2009;85:647– 654.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Hutson JR, Matlow JN, Moretti ME, Koren G. The fetal safety of thiopurines for the treatment of inflammatory bowel disease in pregnancy. J Obstet Gynaecol. 2013;33(1):1–8. doi: 10.3109/01443615.2012.716106</mixed-citation><mixed-citation xml:lang="en">Hutson JR, Matlow JN, Moretti ME, Koren G. The fetal safety of thiopurines for the treatment of inflammatory bowel disease in pregnancy. J Obstet Gynaecol. 2013;33(1):1–8. doi: 10.3109/01443615.2012.716106</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">de Boer NK, Jarbandhan SV, de Graaf P, et al. Azathioprine use during pregnancy: unexpected intrauterine exposure to metabolites. Am J Gastroenterol. 2006;101(6):1390–1392. doi: 10.1111/j.1572-0241.2006.00538.x</mixed-citation><mixed-citation xml:lang="en">de Boer NK, Jarbandhan SV, de Graaf P, et al. Azathioprine use during pregnancy: unexpected intrauterine exposure to metabolites. Am J Gastroenterol. 2006;101(6):1390–1392. doi: 10.1111/j.1572-0241.2006.00538.x</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Jharap B, de Boer NK, Stokkers P, et al. Intrauterine exposure and pharmacology of conventional thiopurine therapy in pregnant patients with inflammatory bowel disease. Gut. 2014;63(3):451–457. doi: 10.1136/gutjnl-2012-303615</mixed-citation><mixed-citation xml:lang="en">Jharap B, de Boer NK, Stokkers P, et al. Intrauterine exposure and pharmacology of conventional thiopurine therapy in pregnant patients with inflammatory bowel disease. Gut. 2014;63(3):451–457. doi: 10.1136/gutjnl-2012-303615</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Selinger CP, Nelson-Piercy C, Fraser A, et al. IBD in pregnancy: recent advances, practical management. Frontline Gastroenterol. 2020 May 19;12(3):214–224. PMID: 33912333; PMCID: PMC8040511. doi: 10.1136/flgastro-2019-101371</mixed-citation><mixed-citation xml:lang="en">Selinger CP, Nelson-Piercy C, Fraser A, et al. IBD in pregnancy: recent advances, practical management. Frontline Gastroenterol. 2020 May 19;12(3):214–224. PMID: 33912333; PMCID: PMC8040511. doi: 10.1136/flgastro-2019-101371</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Akbari M, Shah S, Velayos FS, et al. Systematic review and metaanalysis on the effects of thiopurines on birth outcomes from female and male patients with inflammatory bowel disease. Inflamm Bowel Dis. 2013;19(1):15–22. doi: 10.1002/ibd.22948</mixed-citation><mixed-citation xml:lang="en">Akbari M, Shah S, Velayos FS, et al. Systematic review and metaanalysis on the effects of thiopurines on birth outcomes from female and male patients with inflammatory bowel disease. Inflamm Bowel Dis. 2013;19(1):15–22. doi: 10.1002/ibd.22948</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Kanis SL, de Lima-Karagiannis A, de Boer NKH, et al. Use of thiopurines during conception and pregnancy is not associated with adverse pregnancy outcomes or health of infants at one year in a prospective study. Clin Gastroenterol Hepatol. 2017;15(8):1232–1241. e1. doi: 10.1016/j.cgh.2017.02.041</mixed-citation><mixed-citation xml:lang="en">Kanis SL, de Lima-Karagiannis A, de Boer NKH, et al. Use of thiopurines during conception and pregnancy is not associated with adverse pregnancy outcomes or health of infants at one year in a prospective study. Clin Gastroenterol Hepatol. 2017;15(8):1232–1241. e1. doi: 10.1016/j.cgh.2017.02.041</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Y, Li D, Guo H, et al. Association between Thiopurines Use and Pregnancy Outcomes in Female Patients with Inflammatory Bowel Disease: A Meta-Analysis. Curr Pharm Des. 2021;27(19):2317–2324. PMID: 32938343. doi: 10.2174/1381612826666200916144249</mixed-citation><mixed-citation xml:lang="en">Zhang Y, Li D, Guo H, et al. Association between Thiopurines Use and Pregnancy Outcomes in Female Patients with Inflammatory Bowel Disease: A Meta-Analysis. Curr Pharm Des. 2021;27(19):2317–2324. PMID: 32938343. doi: 10.2174/1381612826666200916144249</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Mahadevan U, McConnell RA, Chambers CD. Drug safety and risk of adverse outcomes for pregnant patients with inflammatory bowel disease. Gastroenterology. 2017;152(2):451–462.e. doi: 10.1053/j.gastro.2016.10.013</mixed-citation><mixed-citation xml:lang="en">Mahadevan U, McConnell RA, Chambers CD. Drug safety and risk of adverse outcomes for pregnant patients with inflammatory bowel disease. Gastroenterology. 2017;152(2):451–462.e. doi: 10.1053/j.gastro.2016.10.013</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Götestam Skorpen C, Hoeltzenbein M, Tincani A, et al. The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. Ann Rheum Dis. 2016;75(5):795–810. doi: 10.1136/annrheumdis-2015-208840</mixed-citation><mixed-citation xml:lang="en">Götestam Skorpen C, Hoeltzenbein M, Tincani A, et al. The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. Ann Rheum Dis. 2016;75(5):795–810. doi: 10.1136/annrheumdis-2015-208840</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Анкилозирующий спондилит: клинические рекомендации. 2018. http://cr.rosminzdrav.ru/#!/schema/175 (Дата доступа: 3.08.2022).</mixed-citation><mixed-citation xml:lang="en">Ankylosing spondylitis: clinical guidelines. 2018. http://cr.rosminzdrav.ru/#!/schema/175 (Date: 3.08.2022). (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации. Ревматоидный артрит. Ассоциация ревматологов России. 2018 г. http://cr.rosminzdrav.ru/#!/recomend/173</mixed-citation><mixed-citation xml:lang="en">Clinical recommendations. Rheumatoid arthritis. Association of Rheumatologists of Russia. 2018 г. http://cr.rosminzdrav.ru/#!/recomend/173 (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Broms G, Granath F, Linder M, et al. Birth outcomes in women with inflammatory bowel disease: effects of disease activity and drug exposure. Inflamm Bowel Dis. 2014;20:1091–1098.</mixed-citation><mixed-citation xml:lang="en">Broms G, Granath F, Linder M, et al. Birth outcomes in women with inflammatory bowel disease: effects of disease activity and drug exposure. Inflamm Bowel Dis. 2014;20:1091–1098.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Lamb CA, Kennedy NA, Raine T, et al. British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults. Gut. 2019 Dec;68(Suppl 3):s1- s106. Epub 2019 Sep 27. Erratum in: Gut. 2021 Apr;70(4):1. PMID: 31562236; PMCID: PMC6872448. doi: 10.1136/gutjnl-2019-318484</mixed-citation><mixed-citation xml:lang="en">Lamb CA, Kennedy NA, Raine T, et al. British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults. Gut. 2019 Dec;68(Suppl 3):s1- s106. Epub 2019 Sep 27. Erratum in: Gut. 2021 Apr;70(4):1. PMID: 31562236; PMCID: PMC6872448. doi: 10.1136/gutjnl-2019-318484</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Государственный реестр лекарственных средств. https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=1d87cc12-bf19-4072-82fe-88ea48f6eb4d</mixed-citation><mixed-citation xml:lang="en">State Register of Medicines. https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=1d87cc12-bf19-4072-82fe-88ea48f6eb4d (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Adachi J, DuPont H. Rifaximin: a novel nonabsorbed rifamycin for gastrointestinal disorders. Expert Rev Anti Infect Ther. 2006;42:541–547.</mixed-citation><mixed-citation xml:lang="en">Adachi J, DuPont H. Rifaximin: a novel nonabsorbed rifamycin for gastrointestinal disorders. Expert Rev Anti Infect Ther. 2006;42:541–547.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Scarpignato C, Pelosini I. Rifaximin, a poorly absorbed antibiotic: pharmacology and clinical potential. Chemotherapy. 2005;51(Suppl 1):36–66.</mixed-citation><mixed-citation xml:lang="en">Scarpignato C, Pelosini I. Rifaximin, a poorly absorbed antibiotic: pharmacology and clinical potential. Chemotherapy. 2005;51(Suppl 1):36–66.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Simister N. Placental transport of immunoglobulin G. Vaccine. 2003;21:3365–9.</mixed-citation><mixed-citation xml:lang="en">Simister N. Placental transport of immunoglobulin G. Vaccine. 2003;21:3365–9.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Mahadevan U, Wolf DC, Dubinsky M, et al. Placental transfer of anti-tumor necrosis factor agents in pregnant patients with inflammatory bowel disease. Clin Gastroenterol Hepatol. 2013;11:quiz e24:286–92.</mixed-citation><mixed-citation xml:lang="en">Mahadevan U, Wolf DC, Dubinsky M, et al. Placental transfer of anti-tumor necrosis factor agents in pregnant patients with inflammatory bowel disease. Clin Gastroenterol Hepatol. 2013;11:quiz e24:286–92.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Julsgaard M, Christensen LA, Gibson PR, et al. Concentrations of Adalimumab and Infliximab in Mothers and Newborns, and Effects on Infection. Gastroenterology. 2016;151:110–9.</mixed-citation><mixed-citation xml:lang="en">Julsgaard M, Christensen LA, Gibson PR, et al. Concentrations of Adalimumab and Infliximab in Mothers and Newborns, and Effects on Infection. Gastroenterology. 2016;151:110–9.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Mariette X, Förger F, Abraham B, et al. Lack of placental transfer of certolizumab pegol during pregnancy: results from CRIB, a prospective, postmarketing, pharmacokinetic study. Ann Rheum Dis. 2018 Feb;77(2):228–233. Epub 2017 Oct 13. PMID: 29030361; PMCID: PMC5867410. doi: 10.1136/annrheumdis-2017-212196</mixed-citation><mixed-citation xml:lang="en">Mariette X, Förger F, Abraham B, et al. Lack of placental transfer of certolizumab pegol during pregnancy: results from CRIB, a prospective, postmarketing, pharmacokinetic study. Ann Rheum Dis. 2018 Feb;77(2):228–233. Epub 2017 Oct 13. PMID: 29030361; PMCID: PMC5867410. doi: 10.1136/annrheumdis-2017-212196</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Ng SC, Shi HY, Hamidi N, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017 Dec 23;390(10114):2769–2778. Epub 2017 Oct 16. Erratum in: Lancet. 2020 Oct 3;396(10256):e56. PMID: 29050646. doi: 10.1016/S0140-6736(17)32448-0</mixed-citation><mixed-citation xml:lang="en">Ng SC, Shi HY, Hamidi N, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017 Dec 23;390(10114):2769–2778. Epub 2017 Oct 16. Erratum in: Lancet. 2020 Oct 3;396(10256):e56. PMID: 29050646. doi: 10.1016/S0140-6736(17)32448-0</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Mahadevan U, Martin C, Kane SV, et al. Do infant serum levels of biologic agents at birth correlate with risk of adverse outcomes? Results from the PIANO Registry. Gastroenterology. 2016;150:S91– S92.</mixed-citation><mixed-citation xml:lang="en">Mahadevan U, Martin C, Kane SV, et al. Do infant serum levels of biologic agents at birth correlate with risk of adverse outcomes? Results from the PIANO Registry. Gastroenterology. 2016;150:S91– S92.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Mahadevan U, Long MD, Kane SV, et al. Pregnancy and neonatal outcomes after fetal exposure to biologics and thiopurines among women with inflammatory bowel disease. Gastroenterol. 2021;160(4):1131–9.</mixed-citation><mixed-citation xml:lang="en">Mahadevan U, Long MD, Kane SV, et al. Pregnancy and neonatal outcomes after fetal exposure to biologics and thiopurines among women with inflammatory bowel disease. Gastroenterol. 2021;160(4):1131–9.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Chaparro M, Verreth A, Lobaton T, et al. Long-Term Safety of In Utero Exposure to Anti-TNFα Drugs for the Treatment of Inflammatory Bowel Disease: Results from the Multicenter European TEDDY Study. Am J Gastroenterol. 2018 Mar;113(3):396–403. Epub 2018 Feb 20. PMID: 29460920. doi: 10.1038/ajg.2017.501</mixed-citation><mixed-citation xml:lang="en">Chaparro M, Verreth A, Lobaton T, et al. Long-Term Safety of In Utero Exposure to Anti-TNFα Drugs for the Treatment of Inflammatory Bowel Disease: Results from the Multicenter European TEDDY Study. Am J Gastroenterol. 2018 Mar;113(3):396–403. Epub 2018 Feb 20. PMID: 29460920. doi: 10.1038/ajg.2017.501</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Scott R, Parker H, Mccartney S, et al. Outcomes following biosimilar TNF inhibitor use for inflammatory-mediated immune disorders in pregnancy. Obstet Med. 2022 Jun;15(2):104– 107. Epub 2021 Sep 2. PMID: 35845229; PMCID: PMC9277732. doi: 10.1177/1753495X211028779</mixed-citation><mixed-citation xml:lang="en">Scott R, Parker H, Mccartney S, et al. Outcomes following biosimilar TNF inhibitor use for inflammatory-mediated immune disorders in pregnancy. Obstet Med. 2022 Jun;15(2):104– 107. Epub 2021 Sep 2. PMID: 35845229; PMCID: PMC9277732. doi: 10.1177/1753495X211028779</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Kanis SL, Modderman S, Escher JC, et al. Initiative on Crohns and Colitis (ICC). Health outcomes of 1000 children born to mothers with inflammatory bowel disease in their first 5 years of life. Gut. 2021 Jul;70(7):1266–1274. Epub 2020 Oct 12. PMID: 33046558; PMCID: PMC8223671. doi: 10.1136/gutjnl-2019-319129</mixed-citation><mixed-citation xml:lang="en">Kanis SL, Modderman S, Escher JC, et al. Initiative on Crohns and Colitis (ICC). Health outcomes of 1000 children born to mothers with inflammatory bowel disease in their first 5 years of life. Gut. 2021 Jul;70(7):1266–1274. Epub 2020 Oct 12. PMID: 33046558; PMCID: PMC8223671. doi: 10.1136/gutjnl-2019-319129</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Luu M, Benzenine E, Doret M, et al. Continuous anti-TNF alpha use throughout pregnancy: possible complications for the mother but not for the fetus. A retrospective cohort on the French National Health Insurance Database (EVASION). Am J Gastroenterol. 2018;113(11):1669–77.</mixed-citation><mixed-citation xml:lang="en">Luu M, Benzenine E, Doret M, et al. Continuous anti-TNF alpha use throughout pregnancy: possible complications for the mother but not for the fetus. A retrospective cohort on the French National Health Insurance Database (EVASION). Am J Gastroenterol. 2018;113(11):1669–77.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Truta B, Canner JK, Fang SH, et al. Outcomes of Continuation vs Discontinuation of Adalimumab Therapy During Third Trimester of Pregnancy in Inflammatory Bowel Disease. Gastro Hep Advances. 2022;1:785–791. doi: 10.1016/j.gastha.2022.04.009</mixed-citation><mixed-citation xml:lang="en">Truta B, Canner JK, Fang SH, et al. Outcomes of Continuation vs Discontinuation of Adalimumab Therapy During Third Trimester of Pregnancy in Inflammatory Bowel Disease. Gastro Hep Advances. 2022;1:785–791. doi: 10.1016/j.gastha.2022.04.009</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Truta B, Leeds IL, Canner JK, et al. Early Discontinuation of Infliximab in Pregnant Women With Inflammatory Bowel Disease. Inflamm Bowel Dis. 2020 Jun 18;26(7):1110–1117. PMID: 31670762. doi: 10.1093/ibd/izz250</mixed-citation><mixed-citation xml:lang="en">Truta B, Leeds IL, Canner JK, et al. Early Discontinuation of Infliximab in Pregnant Women With Inflammatory Bowel Disease. Inflamm Bowel Dis. 2020 Jun 18;26(7):1110–1117. PMID: 31670762. doi: 10.1093/ibd/izz250</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Lau A, Clark M, Harrison DD, et al. Pregnancy outcomes in women exposed to the tumor necrosis factor inhibitor, Golimumab. Ann Rheum Dis. 2014;73(Suppl2):232.2–3.</mixed-citation><mixed-citation xml:lang="en">Lau A, Clark M, Harrison DD, et al. Pregnancy outcomes in women exposed to the tumor necrosis factor inhibitor, Golimumab. Ann Rheum Dis. 2014;73(Suppl2):232.2–3.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Wieringa JW, Driessen GJ, Van Der Woude CJ. Pregnant women with inflammatory bowel disease: the effects of biologicals on pregnancy, outcome of infants, and the developing immune system. Expert Rev Gastroenterol Hepatol. 2018;12(8):811–8.</mixed-citation><mixed-citation xml:lang="en">Wieringa JW, Driessen GJ, Van Der Woude CJ. Pregnant women with inflammatory bowel disease: the effects of biologicals on pregnancy, outcome of infants, and the developing immune system. Expert Rev Gastroenterol Hepatol. 2018;12(8):811–8.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Kolar M, Bortlik M, Duricova D, et al. Pregnancy outcomes in women with inflammatory bowel disease treated with biosimilar infliximab. Gastroenterol Hepatol. 2018;72:20–26.</mixed-citation><mixed-citation xml:lang="en">Kolar M, Bortlik M, Duricova D, et al. Pregnancy outcomes in women with inflammatory bowel disease treated with biosimilar infliximab. Gastroenterol Hepatol. 2018;72:20–26.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Komaki F, Komaki Y, Micic D, et al. Outcome of pregnancy and neonatal complications with anti-tumor necrosis factor-a use in females with immune mediated diseases; a systematic review and meta-analysis. J Autoimmunity. 2017;76:38–52.</mixed-citation><mixed-citation xml:lang="en">Komaki F, Komaki Y, Micic D, et al. Outcome of pregnancy and neonatal complications with anti-tumor necrosis factor-a use in females with immune mediated diseases; a systematic review and meta-analysis. J Autoimmunity. 2017;76:38–52.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Shihab Z, Yeomans ND and de Cruz P. Anti-tumour necrosis factor a therapies and inflammatory bowel disease pregnancy outcomes: a meta-analysis. J Crohns Colitis. 2016;10:979–988.</mixed-citation><mixed-citation xml:lang="en">Shihab Z, Yeomans ND and de Cruz P. Anti-tumour necrosis factor a therapies and inflammatory bowel disease pregnancy outcomes: a meta-analysis. J Crohns Colitis. 2016;10:979–988.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Julsgaard M, Kjeldsen J, Brock B, et al. Letter: vedolizumab drug levels in cord and maternal blood in women with inflammatory bowel disease. Aliment Pharmacol Ther. 2018;48:386–8.</mixed-citation><mixed-citation xml:lang="en">Julsgaard M, Kjeldsen J, Brock B, et al. Letter: vedolizumab drug levels in cord and maternal blood in women with inflammatory bowel disease. Aliment Pharmacol Ther. 2018;48:386–8.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Mahadevan U, Vermeire S, Lasch K, et al. Letter: vedolizumab drug levels in cord and maternal blood in women with inflammatory bowel disease-authors’ reply. Aliment Pharmacol Ther. 2018;48:388–9.</mixed-citation><mixed-citation xml:lang="en">Mahadevan U, Vermeire S, Lasch K, et al. Letter: vedolizumab drug levels in cord and maternal blood in women with inflammatory bowel disease-authors’ reply. Aliment Pharmacol Ther. 2018;48:388–9.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Mitrova K, Pipek B, Bortlik M, et al. Czech IBD Working Group. Safety of ustekinumab and vedolizumab during pregnancy — pregnancy, neonatal and infant outcome: a prospective multicenter study. J Crohns Colitis. 2022 Jun 16:jjac086. Epub ahead of print. PMID: 35708729. doi: 10.1093/ecco-jcc/jjac086</mixed-citation><mixed-citation xml:lang="en">Mitrova K, Pipek B, Bortlik M, et al. Czech IBD Working Group. Safety of ustekinumab and vedolizumab during pregnancy — pregnancy, neonatal and infant outcome: a prospective multicenter study. J Crohns Colitis. 2022 Jun 16:jjac086. Epub ahead of print. PMID: 35708729. doi: 10.1093/ecco-jcc/jjac086</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Crawford D, Friedman M. Evaluation of the Developmental Toxicity of Vedolizumab, an α4 β7 Receptor Antagonist, in Rabbit and Nonhuman Primate. Int J Toxicol. 2019;38:395–404.</mixed-citation><mixed-citation xml:lang="en">Crawford D, Friedman M. Evaluation of the Developmental Toxicity of Vedolizumab, an α4 β7 Receptor Antagonist, in Rabbit and Nonhuman Primate. Int J Toxicol. 2019;38:395–404.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Moens A, van der Woude CJ, Julsgaard M, et al. Pregnancy outcomes in inflammatory bowel disease patients treated with vedolizumab, anti-TNF or conventional therapy: results of the European CONCEIVE study. Aliment Pharmacol Ther. 2020;51(1):129–138. doi: 10.1111/apt.15539</mixed-citation><mixed-citation xml:lang="en">Moens A, van der Woude CJ, Julsgaard M, et al. Pregnancy outcomes in inflammatory bowel disease patients treated with vedolizumab, anti-TNF or conventional therapy: results of the European CONCEIVE study. Aliment Pharmacol Ther. 2020;51(1):129–138. doi: 10.1111/apt.15539</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Bar-Gil Shitrit A, Ben Yaʼacov A, Livovsky DM, et al. Exposure to Vedolizumab in IBD Pregnant Women Appears of Low Risk for Mother and Neonate: A First Prospective Comparison Study. Am J Gastroenterol. 2019;114(7):1172–1175. doi: 10.14309/ajg.0000000000000186</mixed-citation><mixed-citation xml:lang="en">Bar-Gil Shitrit A, Ben Yaʼacov A, Livovsky DM, et al. Exposure to Vedolizumab in IBD Pregnant Women Appears of Low Risk for Mother and Neonate: A First Prospective Comparison Study. Am J Gastroenterol. 2019;114(7):1172–1175. doi: 10.14309/ajg.0000000000000186</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Nielsen OH, Gubatan JM, Juhl CB, et al. Biologics for Inflammatory Bowel Disease and Their Safety in Pregnancy: A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2022 Jan;20(1):74–87.e3. Epub 2020 Sep 12. PMID: 32931960. doi: 10.1016/j.cgh.2020.09.021</mixed-citation><mixed-citation xml:lang="en">Nielsen OH, Gubatan JM, Juhl CB, et al. Biologics for Inflammatory Bowel Disease and Their Safety in Pregnancy: A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2022 Jan;20(1):74–87.e3. Epub 2020 Sep 12. PMID: 32931960. doi: 10.1016/j.cgh.2020.09.021</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Martin PL, Sachs C, Imai N, et al. Development in the cynomolgus macaque following administration of ustekinumab, a human antiIL-12/23p40 monoclonal antibody, during pregnancy and lactation. Birth Defects Res B Dev Reprod Toxicol. 2010;89(5):351–63.</mixed-citation><mixed-citation xml:lang="en">Martin PL, Sachs C, Imai N, et al. Development in the cynomolgus macaque following administration of ustekinumab, a human antiIL-12/23p40 monoclonal antibody, during pregnancy and lactation. Birth Defects Res B Dev Reprod Toxicol. 2010;89(5):351–63.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Mugheddu C, Atzori L, Lappi A, et al. Biologics exposure during pregnancy and breastfeeding in a psoriasis patient. Dermatol Ther. 2019;32(3):e12895. 32.</mixed-citation><mixed-citation xml:lang="en">Mugheddu C, Atzori L, Lappi A, et al. Biologics exposure during pregnancy and breastfeeding in a psoriasis patient. Dermatol Ther. 2019;32(3):e12895. 32.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Wils P, Seksik P, Stefanescu C, et al. Safety of ustekinumab or vedolizumab in pregnant inflammatory bowel disease patients: a multicentre cohort study. Aliment Pharmacol Ther. 2021;53(4):460– 70.</mixed-citation><mixed-citation xml:lang="en">Wils P, Seksik P, Stefanescu C, et al. Safety of ustekinumab or vedolizumab in pregnant inflammatory bowel disease patients: a multicentre cohort study. Aliment Pharmacol Ther. 2021;53(4):460– 70.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">de Lima A, Zelinkova Z, van der Ent C, et al. Tailored anti-TNF therapy during pregnancy in patients with IBD: maternal and fetal safety. Gut. 2016;65:1261–8.</mixed-citation><mixed-citation xml:lang="en">de Lima A, Zelinkova Z, van der Ent C, et al. Tailored anti-TNF therapy during pregnancy in patients with IBD: maternal and fetal safety. Gut. 2016;65:1261–8.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Seirafi M, de Vroey B, Amiot A, et al. Factors associated with pregnancy outcome in anti-TNF treated women with inflammatory bowel disease. Aliment Pharmacol Ther. 2014;40(4):363–73.</mixed-citation><mixed-citation xml:lang="en">Seirafi M, de Vroey B, Amiot A, et al. Factors associated with pregnancy outcome in anti-TNF treated women with inflammatory bowel disease. Aliment Pharmacol Ther. 2014;40(4):363–73.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Mahadevan U, Naureckas S, Tikhonov I, et al. Pregnancy outcomes following periconceptional or gestational exposure to ustekinumab: Review of cases reported to the manufacturer’s global safety database. Aliment Pharmacol Ther. 2022 Aug;56(3):477–490. Epub 2022 May 12. PMID: 35560249. doi: 10.1111/apt.16960</mixed-citation><mixed-citation xml:lang="en">Mahadevan U, Naureckas S, Tikhonov I, et al. Pregnancy outcomes following periconceptional or gestational exposure to ustekinumab: Review of cases reported to the manufacturer’s global safety database. Aliment Pharmacol Ther. 2022 Aug;56(3):477–490. Epub 2022 May 12. PMID: 35560249. doi: 10.1111/apt.16960</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Armuzzi A, Bortoli A, Castiglione F, et al. Italian Group for the Study of Inflammatory Bowel Disease Working Group. Female reproductive health and inflammatory bowel disease: A practice-based review. Dig Liver Dis. 2022 Jan;54(1):19–29. Epub 2021 Jun 11. PMID: 34120858. doi: 10.1016/j.dld.2021.05.020</mixed-citation><mixed-citation xml:lang="en">Armuzzi A, Bortoli A, Castiglione F, et al. Italian Group for the Study of Inflammatory Bowel Disease Working Group. Female reproductive health and inflammatory bowel disease: A practice-based review. Dig Liver Dis. 2022 Jan;54(1):19–29. Epub 2021 Jun 11. PMID: 34120858. doi: 10.1016/j.dld.2021.05.020</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Picardo S, Seow CH. A pharmacological approach to managing inflammatory bowel disease during conception, pregnancy and breastfeeding: biologic and oral small molecule therapy. Drugs. 2019;79:1053–63.</mixed-citation><mixed-citation xml:lang="en">Picardo S, Seow CH. A pharmacological approach to managing inflammatory bowel disease during conception, pregnancy and breastfeeding: biologic and oral small molecule therapy. Drugs. 2019;79:1053–63.</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Clowse ME, Feldman SR, Isaacs JD, et al. Pregnancy outcomes in the tofacitinib safety databases for rheumatoid arthritis and psoriasis. Drug Saf. 2016;39:755–62.</mixed-citation><mixed-citation xml:lang="en">Clowse ME, Feldman SR, Isaacs JD, et al. Pregnancy outcomes in the tofacitinib safety databases for rheumatoid arthritis and psoriasis. Drug Saf. 2016;39:755–62.</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Yu A, Friedman S, Ananthakrishnan AN. Incidence and Predictors of Flares in the Postpartum Year Among Women With Inflammatory Bowel Disease. Inflamm Bowel Dis. 2020 Nov 19;26(12):1926–1932. PMID: 31895410; PMCID: PMC7676422. doi: 10.1093/ibd/izz313</mixed-citation><mixed-citation xml:lang="en">Yu A, Friedman S, Ananthakrishnan AN. Incidence and Predictors of Flares in the Postpartum Year Among Women With Inflammatory Bowel Disease. Inflamm Bowel Dis. 2020 Nov 19;26(12):1926–1932. PMID: 31895410; PMCID: PMC7676422. doi: 10.1093/ibd/izz313</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Kane S, Lemieux N. The role of breastfeeding in postpartum disease activity in women with inflammatory bowel disease. Am J Gastroenterol. 2005 Jan;100(1):102–5. PMID: 15654788. doi: 10.1111/j.1572-0241.2005.40785.x</mixed-citation><mixed-citation xml:lang="en">Kane S, Lemieux N. The role of breastfeeding in postpartum disease activity in women with inflammatory bowel disease. Am J Gastroenterol. 2005 Jan;100(1):102–5. PMID: 15654788. doi: 10.1111/j.1572-0241.2005.40785.x</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">Mañosa M, Navarro-Llavat M, Marín L, et al. Fecundity, pregnancy outcomes, and breastfeeding in patients with inflammatory bowel disease: a large cohort survey. Scand J Gastroenterol. 2013 Apr;48(4):427–32. Epub 2013 Mar 11. PMID: 23477328. doi: 10.3109/00365521.2013.772229</mixed-citation><mixed-citation xml:lang="en">Mañosa M, Navarro-Llavat M, Marín L, et al. Fecundity, pregnancy outcomes, and breastfeeding in patients with inflammatory bowel disease: a large cohort survey. Scand J Gastroenterol. 2013 Apr;48(4):427–32. Epub 2013 Mar 11. PMID: 23477328. doi: 10.3109/00365521.2013.772229</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">Selinger CP, Eaden J, Selby W, et al. Inflammatory bowel disease and pregnancy: lack of knowledge is associated with negative views. J Crohns Colitis. 2013;7:e206-13.</mixed-citation><mixed-citation xml:lang="en">Selinger CP, Eaden J, Selby W, et al. Inflammatory bowel disease and pregnancy: lack of knowledge is associated with negative views. J Crohns Colitis. 2013;7:e206-13.</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">Barclay AR, Russell RK, Wilson ML, et al. Systematic review: the role of breastfeeding in the development of pediatric inflammatory bowel disease. J Pediatr. 2009 Sep;155(3):421–6. Epub 2009 May 22. PMID: 19464699. doi: 10.1016/j.jpeds.2009.03.017</mixed-citation><mixed-citation xml:lang="en">Barclay AR, Russell RK, Wilson ML, et al. Systematic review: the role of breastfeeding in the development of pediatric inflammatory bowel disease. J Pediatr. 2009 Sep;155(3):421–6. Epub 2009 May 22. PMID: 19464699. doi: 10.1016/j.jpeds.2009.03.017</mixed-citation></citation-alternatives></ref><ref id="cit86"><label>86</label><citation-alternatives><mixed-citation xml:lang="ru">Datta P, Rewers-Felkins K, Kallem RR, et al. Determination of Mesalamine levels in Human Milk as a Function of Dose. Breastfeed Med. 2019 Mar;14(2):98–101. Epub 2018 Nov 15. PMID: 30431332. doi: 10.1089/bfm.2018.0111</mixed-citation><mixed-citation xml:lang="en">Datta P, Rewers-Felkins K, Kallem RR, et al. Determination of Mesalamine levels in Human Milk as a Function of Dose. Breastfeed Med. 2019 Mar;14(2):98–101. Epub 2018 Nov 15. PMID: 30431332. doi: 10.1089/bfm.2018.0111</mixed-citation></citation-alternatives></ref><ref id="cit87"><label>87</label><citation-alternatives><mixed-citation xml:lang="ru">Jarnerot G, Into-Malmberg MB. Sulphasalazine treatment during breast feeding. Scand J Gastroenterol. 1979;14:869–871.</mixed-citation><mixed-citation xml:lang="en">Jarnerot G, Into-Malmberg MB. Sulphasalazine treatment during breast feeding. Scand J Gastroenterol. 1979;14:869–871.</mixed-citation></citation-alternatives></ref><ref id="cit88"><label>88</label><citation-alternatives><mixed-citation xml:lang="ru">Branski D, Kerem E, Gross-Kieselstein E, et al. Bloody diarrhoea — a possible complication of sulfasalazine transferred through human breast milk. J Pediatr Gastr Nutr. 1986;5:316–317.</mixed-citation><mixed-citation xml:lang="en">Branski D, Kerem E, Gross-Kieselstein E, et al. Bloody diarrhoea — a possible complication of sulfasalazine transferred through human breast milk. J Pediatr Gastr Nutr. 1986;5:316–317.</mixed-citation></citation-alternatives></ref><ref id="cit89"><label>89</label><citation-alternatives><mixed-citation xml:lang="ru">Christensen LA, Dahlerup JF, Nielsen MJ, et al. Azathioprine treatment during lactation. Aliment Pharmacol Ther. 2008 Nov 15;28(10):1209–13. Epub 2008 Aug 30. PMID: 18761704. doi: 10.1111/j.1365-2036.2008.03843.x</mixed-citation><mixed-citation xml:lang="en">Christensen LA, Dahlerup JF, Nielsen MJ, et al. Azathioprine treatment during lactation. Aliment Pharmacol Ther. 2008 Nov 15;28(10):1209–13. Epub 2008 Aug 30. PMID: 18761704. doi: 10.1111/j.1365-2036.2008.03843.x</mixed-citation></citation-alternatives></ref><ref id="cit90"><label>90</label><citation-alternatives><mixed-citation xml:lang="ru">Angelberger S, Reinisch W, Messerschmidt A, et al. Long-term follow-up of babies exposed to azathioprine in utero and via breastfeeding. J Crohns Colitis. 2011 Apr;5(2):95–100. Epub 2010 Dec 9. PMID: 21453877. doi: 10.1016/j.crohns.2010.10.005</mixed-citation><mixed-citation xml:lang="en">Angelberger S, Reinisch W, Messerschmidt A, et al. Long-term follow-up of babies exposed to azathioprine in utero and via breastfeeding. J Crohns Colitis. 2011 Apr;5(2):95–100. Epub 2010 Dec 9. PMID: 21453877. doi: 10.1016/j.crohns.2010.10.005</mixed-citation></citation-alternatives></ref><ref id="cit91"><label>91</label><citation-alternatives><mixed-citation xml:lang="ru">Ost L, Wettrell G, Björkhem I, et al. Prednisolone excretion in human milk. J Pediatr. 1985 Jun;106(6):1008–11. PMID: 3998938. doi: 10.1016/s0022-3476(85)80259-6</mixed-citation><mixed-citation xml:lang="en">Ost L, Wettrell G, Björkhem I, et al. Prednisolone excretion in human milk. J Pediatr. 1985 Jun;106(6):1008–11. PMID: 3998938. doi: 10.1016/s0022-3476(85)80259-6</mixed-citation></citation-alternatives></ref><ref id="cit92"><label>92</label><citation-alternatives><mixed-citation xml:lang="ru">Greenberger PA, Odeh YK, Frederiksen MC, et al. Pharmacokinetics of prednisolone transfer to breast milk. Clin Pharmacol Ther. 1993 Mar;53(3):324–8. PMID: 8453851. doi: 10.1038/clpt.1993.28</mixed-citation><mixed-citation xml:lang="en">Greenberger PA, Odeh YK, Frederiksen MC, et al. Pharmacokinetics of prednisolone transfer to breast milk. Clin Pharmacol Ther. 1993 Mar;53(3):324–8. PMID: 8453851. doi: 10.1038/clpt.1993.28</mixed-citation></citation-alternatives></ref><ref id="cit93"><label>93</label><citation-alternatives><mixed-citation xml:lang="ru">American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776–89. PMID: 11533352. doi: 10.1542/peds.108.3.776</mixed-citation><mixed-citation xml:lang="en">American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776–89. PMID: 11533352. doi: 10.1542/peds.108.3.776</mixed-citation></citation-alternatives></ref><ref id="cit94"><label>94</label><citation-alternatives><mixed-citation xml:lang="ru">Ben-Horin S, Yavzori M, Katz L, et al. Adalimumab level in breast milk of a nursing mother. Clin Gastroenterol Hepatol. 2010;8(5):475– 6.</mixed-citation><mixed-citation xml:lang="en">Ben-Horin S, Yavzori M, Katz L, et al. Adalimumab level in breast milk of a nursing mother. Clin Gastroenterol Hepatol. 2010;8(5):475– 6.</mixed-citation></citation-alternatives></ref><ref id="cit95"><label>95</label><citation-alternatives><mixed-citation xml:lang="ru">Ben-Horin S, Yavzori M, Kopylov U, et al. Detection of infliximab in breast milk of nursing mothers with inflammatory bowel disease. J Crohns Colitis. 2011;5(6):555–8.</mixed-citation><mixed-citation xml:lang="en">Ben-Horin S, Yavzori M, Kopylov U, et al. Detection of infliximab in breast milk of nursing mothers with inflammatory bowel disease. J Crohns Colitis. 2011;5(6):555–8.</mixed-citation></citation-alternatives></ref><ref id="cit96"><label>96</label><citation-alternatives><mixed-citation xml:lang="ru">Fritzsche J, Pilch A, Mury D, et al. Infiximab and adalimumab use during breastfeeding. J Clin Gastroenterol. 2012;46(8):718–9.</mixed-citation><mixed-citation xml:lang="en">Fritzsche J, Pilch A, Mury D, et al. Infiximab and adalimumab use during breastfeeding. J Clin Gastroenterol. 2012;46(8):718–9.</mixed-citation></citation-alternatives></ref><ref id="cit97"><label>97</label><citation-alternatives><mixed-citation xml:lang="ru">Matro R, Martin CF, Wolf D, et al. Exposure Concentrations of Infants Breastfed by Women Receiving Biologic Therapies for Inflammatory Bowel Diseases and Effects of Breastfeeding on Infections and Development. Gastroenterology. 2018 Sep;155(3):696–704. Epub 2018 May 30. PMID: 29857090. doi: 10.1053/j.gastro.2018.05.040</mixed-citation><mixed-citation xml:lang="en">Matro R, Martin CF, Wolf D, et al. Exposure Concentrations of Infants Breastfed by Women Receiving Biologic Therapies for Inflammatory Bowel Diseases and Effects of Breastfeeding on Infections and Development. Gastroenterology. 2018 Sep;155(3):696–704. Epub 2018 May 30. PMID: 29857090. doi: 10.1053/j.gastro.2018.05.040</mixed-citation></citation-alternatives></ref><ref id="cit98"><label>98</label><citation-alternatives><mixed-citation xml:lang="ru">Clowse ME, Förger F, Hwang C, et al. Minimal to no transfer of certolizumab pegol into breast milk: results from CRADLE, a prospective, postmarketing, multicentre, pharmacokinetic study. Ann Rheum Dis. 2017;76(11):1890–6.</mixed-citation><mixed-citation xml:lang="en">Clowse ME, Förger F, Hwang C, et al. Minimal to no transfer of certolizumab pegol into breast milk: results from CRADLE, a prospective, postmarketing, multicentre, pharmacokinetic study. Ann Rheum Dis. 2017;76(11):1890–6.</mixed-citation></citation-alternatives></ref><ref id="cit99"><label>99</label><citation-alternatives><mixed-citation xml:lang="ru">Puchner A, Gröchenig HP, Sautner J, et al. Immunosuppressives and biologics during pregnancy and lactation : A consensus report issued by the Austrian Societies of Gastroenterology and Hepatology and Rheumatology and Rehabilitation. Wien Klin Wochenschr. 2019 Jan;131(1-2):29–44. Epub 2019 Jan 14. PMID: 30643992; PMCID: PMC6342891. doi: 10.1007/s00508-019-1448-y</mixed-citation><mixed-citation xml:lang="en">Puchner A, Gröchenig HP, Sautner J, et al. Immunosuppressives and biologics during pregnancy and lactation : A consensus report issued by the Austrian Societies of Gastroenterology and Hepatology and Rheumatology and Rehabilitation. Wien Klin Wochenschr. 2019 Jan;131(1-2):29–44. Epub 2019 Jan 14. PMID: 30643992; PMCID: PMC6342891. doi: 10.1007/s00508-019-1448-y</mixed-citation></citation-alternatives></ref><ref id="cit100"><label>100</label><citation-alternatives><mixed-citation xml:lang="ru">Sun W, Fennimore B, Beaulieu DB, et al. Vedolizumab Concentrations in Breast Milk: Results from a Prospective, Postmarketing, Milk-Only Lactation Study in Nursing Mothers with Inflammatory Bowel Disease. Clin Pharmacokinet. 2021 Jun;60(6):811–818. Epub 2021 Feb 5. PMID: 33544318; PMCID: PMC8195772. doi: 10.1007/s40262-021-00985-4</mixed-citation><mixed-citation xml:lang="en">Sun W, Fennimore B, Beaulieu DB, et al. Vedolizumab Concentrations in Breast Milk: Results from a Prospective, Postmarketing, Milk-Only Lactation Study in Nursing Mothers with Inflammatory Bowel Disease. Clin Pharmacokinet. 2021 Jun;60(6):811–818. Epub 2021 Feb 5. PMID: 33544318; PMCID: PMC8195772. doi: 10.1007/s40262-021-00985-4</mixed-citation></citation-alternatives></ref><ref id="cit101"><label>101</label><citation-alternatives><mixed-citation xml:lang="ru">Julsgaard M, Kjeldsen J, Bibby BM, et al. Vedolizumab concentrations in the breast milk of nursing mothers with infammatory bowel disease. Gastroenterology. 2018;154(3):752–4.e1.</mixed-citation><mixed-citation xml:lang="en">Julsgaard M, Kjeldsen J, Bibby BM, et al. Vedolizumab concentrations in the breast milk of nursing mothers with infammatory bowel disease. Gastroenterology. 2018;154(3):752–4.e1.</mixed-citation></citation-alternatives></ref><ref id="cit102"><label>102</label><citation-alternatives><mixed-citation xml:lang="ru">Lahat A, Shitrit AB, Naftali T, et al. Vedolizumab levels in breast milk of nursing mothers with infammatory bowel disease. J Crohns Colitis. 2018;12.</mixed-citation><mixed-citation xml:lang="en">Lahat A, Shitrit AB, Naftali T, et al. Vedolizumab levels in breast milk of nursing mothers with infammatory bowel disease. J Crohns Colitis. 2018;12.</mixed-citation></citation-alternatives></ref><ref id="cit103"><label>103</label><citation-alternatives><mixed-citation xml:lang="ru">Beaulieu DB, Ananthakrishnan AN, Martin C, et al. Use of biologic therapy by pregnant women with inflammatory bowel disease does not affect infant response to vaccines. Clin Gastroenterol Hepatol. 2018;16:99–105.</mixed-citation><mixed-citation xml:lang="en">Beaulieu DB, Ananthakrishnan AN, Martin C, et al. Use of biologic therapy by pregnant women with inflammatory bowel disease does not affect infant response to vaccines. Clin Gastroenterol Hepatol. 2018;16:99–105.</mixed-citation></citation-alternatives></ref><ref id="cit104"><label>104</label><citation-alternatives><mixed-citation xml:lang="ru">de Lima A, Kanis SL, Escher JC, et al. Hepatitis B vaccination effective in children exposed to anti-tumour necrosis factor alpha in utero. J Crohns Colitis. 2018;12:948–53.</mixed-citation><mixed-citation xml:lang="en">de Lima A, Kanis SL, Escher JC, et al. Hepatitis B vaccination effective in children exposed to anti-tumour necrosis factor alpha in utero. J Crohns Colitis. 2018;12:948–53.</mixed-citation></citation-alternatives></ref><ref id="cit105"><label>105</label><citation-alternatives><mixed-citation xml:lang="ru">Bendaoud S, Nahon S, Gornet J-M, et al. Live-vaccines and lactation in newborn exposed in utero to anti-TNF: A multi-centre French experience in inflammatory bowel disease. J Crohn’s Colitis. 2018;12(Suppl 1):S527.</mixed-citation><mixed-citation xml:lang="en">Bendaoud S, Nahon S, Gornet J-M, et al. Live-vaccines and lactation in newborn exposed in utero to anti-TNF: A multi-centre French experience in inflammatory bowel disease. J Crohn’s Colitis. 2018;12(Suppl 1):S527.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
