gnckКолопроктологияKoloproktologia2073-75562686-7303Russian Association of Coloproctology10.33878/10.33878/2073-7556-2022-21-4-39-48gnck-1754Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESМагнитно-резонансная энтероколонография в оценке активности воспалительного процесса при болезни Крона с применением индексов CDMI и MEGSMagnetic resonance enterocolonography for assessing inflammation activity in Crohn’s disease using the CDMI and MEGS indiceshttps://orcid.org/0000-0002-9442-7480ЗароднюкИ. В.ZarodnyukI. V.

ул. Саляма Адиля, д. 2, г. Москва, 123423

Salyama Adilya str., 2, Moscow, 123423

zarodnyuk_iv@gnck.ruhttps://orcid.org/0000-0001-9885-6824ЕлигулашвилиР. Р.EligulashviliR. R.

ул. Саляма Адиля, д. 2, г. Москва, 123423

Salyama Adilya str., 2, Moscow, 123423

https://orcid.org/0000-0001-9992-119XВеселовВ. В.VeselovV. V.

ул. Саляма Адиля, д. 2, г. Москва, 123423

Salyama Adilya str., 2, Moscow, 123423

https://orcid.org/0000-0002-0577-0528МихальченкоВ. А.MikhalchenkoV. A.

ул. Саляма Адиля, д. 2, г. Москва, 123423

Salyama Adilya str., 2, Moscow, 123423

https://orcid.org/0000-0003-1697-4670НанаеваБ. А.NanaevaB. A.

ул. Саляма Адиля, д. 2, г. Москва, 123423

Salyama Adilya str., 2, Moscow, 123423

https://orcid.org/0000-0001-6781-2458ВарданянА. В.VardanyanA. V.

ул. Саляма Адиля, д. 2, г. Москва, 123423

Salyama Adilya str., 2, Moscow, 123423

https://orcid.org/0000-0002-7778-8049ПедаЕ. С.PedaE. S.

ул. Саляма Адиля, д. 2, г. Москва, 123423

Salyama Adilya str., 2, Moscow, 123423

ФГБУ «НМИЦ колопроктологии имени А.Н. Рыжих» Минздрава РоссииРоссияRyzhikh National Medical Research Center of ColoproctologyRussian Federation2022211220222143948Copyright © Зароднюк И.В., Елигулашвили Р.Р., Веселов В.В., Михальченко В.А., Нанаева Б.А., Варданян А.В., Педа Е.С., 20222022Зароднюк И.В., Елигулашвили Р.Р., Веселов В.В., Михальченко В.А., Нанаева Б.А., Варданян А.В., Педа Е.С.Zarodnyuk I.V., Eligulashvili R.R., Veselov V.V., Mikhalchenko V.A., Nanaeva B.A., Vardanyan A.V., Peda E.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.ruproctology.com/jour/article/view/1754ЦЕЛЬ ИССЛЕДОВАНИЯ

ЦЕЛЬ ИССЛЕДОВАНИЯ: определить диагностическую эффективность магнитно-резонансной энтероколонографии с использованием индексов воспаления (CDMI, MEGS) в оценке активности воспалительного процесса в толстой и тонкой кишке при болезни Крона.

ПАЦИЕНТЫ И МЕТОДЫ

ПАЦИЕНТЫ И МЕТОДЫ: в исследование включено 42 пациента с болезнью Крона (возраст варьировался от 19 до 47 лет). Всем больным выполнена магнитно-резонансная энтероколонография (МРЭ) с внутривенным контрастированием и диффузионно-взвешенными изображениями. По результатам МРЭ определялись МР-индексы активности воспаления в тонкой и толстой кишке CDMI и MEGS. МР-индексы активности воспалительного процесса CDMI и MEGS сравнивались с эндоскопическим индексом активности воспаления SES-CD.

РЕЗУЛЬТАТЫ ИССЛЕДОВАНИЯ

РЕЗУЛЬТАТЫ ИССЛЕДОВАНИЯ: МР-индекс активности воспаления CDMI не показал статиcтически значимую диагностическую эффективность (p>0.05). МР-индекс активности воспаления MEGS показал статиcтически значимую диагностическую эффективность (p<0,0001). При анализе номограммы МР-индекс активности воспаления MEGS продемонстрировал высокую предсказательную способность определения истинной активности воспалительного процесса в тонкой и толстой кишке. При анализе корреляции между количественными значениями индексов воспаления MEGS и эндоскопическим индексом воспаления (SES-CD) выявлена прямая сильная связь между ними (r=0,843, p<0,0001).

ЗАКЛЮЧЕНИЕ

ЗАКЛЮЧЕНИЕ: магнитно-резонансная энтероколонография с использованием индекса активности MEGS обладает высокой диагностической эффективностью в оценке активности воспалительного процесса в тонкой и толстой кишке при болезни Крона. МР-индекс активности воспаления CDMI не показал статиcтически значимую диагностическую эффективность. Результаты исследования следует считать предварительными, и требуют дальнейшего изучения возможностей данных индексов активности воспаления на большей выборке пациентов.

AIM

AIM: to determine the diagnostic efficiency of magnetic resonance enterocolonography using inflammation indices (CDMI, MEGS) in assessing activity of the inflammatory process in the colon and small intestine in Crohn's disease.

PATIENTS AND METHODS

PATIENTS AND METHODS: the study included 42 patients with Crohn's disease (age ranged from 19 to 47 years). All patients underwent magnetic resonance enterocolonography (MRE) with intravenous contrast and diffusion-weighted images. According to the results of MRE, were determined MR indices of inflammation activity in the small and large intestine - CDMI and MEGS. The MR inflammatory activity indices CDMI and MEGS were compared with the endoscopic inflammatory activity index SES-CD.

RESULTS

RESULTS: the MR inflammation activity index CDMI did not show a statistically significant diagnostic efficiency (p>0.05). The MR inflammation activity index MEGS showed a statistically significant diagnostic efficiency (p<0.0001). According to the nomogram, the MR inflammation activity index MEGS demonstrated a high predictive ability to determine the true activity of the inflammatory process in the small and large intestine. Correlation demonstrated direct strong relationship between the quantitative values of the MEGS inflammation indices and the endoscopic inflammation index (SES-CD) (r=0.843, p<0.0001).

CONCLUSION

CONCLUSION: magnetic resonance enterocolonography using the MEGS activity index has a high diagnostic efficiency in assessing the activity of the inflammatory process in the small and large intestine in Crohn's disease. The MR inflammation activity index CDMI did not show statistically significant diagnostic efficacy. The results of the study should be considered preliminary and require further study of the possibilities of these indices of inflammation activity in a larger sample of patients.

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The authors declare that there are no conflicts of interest present.