gnckКолопроктологияKoloproktologia2073-75562686-7303Russian Association of Coloproctology10.33878/2073-7556-2021-20-1-68-76gnck-1626Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWРоль кишечной микробиоты в колоректальном канцерогенезе (обзор литературы)Role of intestinal microbiota in colorectal carcinogenesis (review)https://orcid.org/0000-0003-4795-0751СухинаМ. А.SukhinaM. A.

Сухина Марина Алексеевна

ул. Саляма Адиля, д. 2, Москва, 123423

eLibrary SPIN: 9577-5290

Marina A. Sukhina

Salama Adilya str. 2, Moscow, 123423

eLibrary SPIN: 9577-5290

marinamari272015@gmail.comhttps://orcid.org/0000-0001-5434-9062ЛягинаИ. А.LyaginaI. A.

Лягина Ирина Анатольевна

ул. Саляма Адиля, д. 2, Москва, 123423

Irina A. Lyagina

Salama Adilya str. 2, Moscow, 123423

lyagina59@mail.ruhttps://orcid.org/0000-0001-8013-3863СафинА. Л.SafinA. L.

Сафин Антон Люнерович

ул. Саляма Адиля, д. 2, Москва, 123423

Anton L. Safin

Salama Adilya str. 2, Moscow, 123423

antonyz@rambler.ruhttps://orcid.org/0000-0002-6464-2462ФроловС. А.FrolovS. A.

Фролов Сергей Алексеевич

ул. Саляма Адиля, д. 2, Москва, 123423

Sergey A. Frolov

Salama Adilya str. 2, Moscow, 123423

safrolov@mail.ruhttps://orcid.org/0000-0002-7929-9986КашниковВ. Н.KashnikovV. N.

Кашников Владимир Николаевич

ул. Саляма Адиля, д. 2, Москва, 123423

Vladimir N. Kashnikov

Salama Adilya str. 2, Moscow, 123423

kashnikov-v@yandex.ruФГБУ "НМИЦ колопроктологии имени А.Н. Рыжих" Минздрава РоссииРоссияRyzhikh National Medical Research Center of ColoproctologyRussian Federation2021210320212016876Copyright © Сухина М.А., Лягина И.А., Сафин А.Л., Фролов С.А., Кашников В.Н., 20212021Сухина М.А., Лягина И.А., Сафин А.Л., Фролов С.А., Кашников В.Н.Sukhina M.A., Lyagina I.A., Safin A.L., Frolov S.A., Kashnikov V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.ruproctology.com/jour/article/view/1626

Цель обзора литературы – показать возможные связи между кишечной микробиотой и канцерогенезом колоректального рака, описать проканцерогенные свойства микроорганизмов, связанных с возникновением или пролиферацией рака. Кишечная микробиота играет ведущую роль в метаболизме, предоставляя важные метаболиты макроорганизму. В организме человека существует пространственная изменчивость в качественном и количественном составе микробиоты. Кишечная микробиота обеспечивает колониерезистентность организма человека, защищая его от колонизации условнопатогенными и патогенными микроорганизмами. Все больше появляется данных о роли кишечной микробиоты в возникновении и развитии колоректального рака. Требуется углубленное исследования кишечного микробиома в различных популяциях, что позволит идентифицировать другие микроорганизмы, связанные с возникновением или пролиферацией КРР, которые в дальнейшем могут быть использованы в качестве биомаркеров для скрининга КРР и прогнозирования ответа на иммунотерапию.

The aim of the review is to show possible links between intestinal microbiota and colorectal carcinogenesis, to describe the procarcinogenic properties of microorganisms associated with the development or proliferation of colorectal cancer. The gut microbiota plays a leading role in metabolism, providing important metabolites to the macroorganism. In humans, there is a spatial variability in the qualitative and quantitative microbiota composition. The intestinal microbiota provides the colony resistance, protecting it from colonization by opportunistic and pathogenic microorganisms. There is more and more data on the role of the gut microbiota in the development of colorectal cancer. The profound study of the gut microbiome in various populations is required, which will allow to identify other microorganisms associated with the development or proliferation of colorectal cancer. It can be used as biomarkers for colorectal cancer screening and predicting the response to immunotherapy.

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The authors declare that there are no conflicts of interest present.