gnckКолопроктологияKoloproktologia2073-75562686-7303Russian Association of Coloproctology10.33878/2073-7556-2020-19-4-177-187gnck-1610Research ArticleОБЗОРЫ ЛИТЕРАТУРЫ И МЕТААНАЛИЗLITERATURE REVIEWS AND METAANALYSISМОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКИЕ ОСОБЕННОСТИ ОПУХОЛЕЙ ТОЛСТОЙ КИШКИ ПРИ ПЕРИТОНЕАЛЬНОМ КАРЦИНОМАТОЗЕ И МЕТАСТАЗАХ РАКА В ПЕЧЕНИ (обзор литературы)MOLECULAR-GENETIC FEATURES OF COLORECTAL TUMORS IN PERITONEAL CARCINOMATOSIS AND LIVER METASTASES (review)https://orcid.org/0000-0002-3820-7651ШубинВ. П.ShubinV. P.

Кандидат биологических наук, старший научный сотрудник отдела лабораторной генетики, 6308-6586

ул.Саляма Адиля, д.2, г.Москва, 123423, Россия

тел.: +7(916)3445479

Salyama Adilya str., 2, Moscow, 123423, Russia

+7(916)3445479

shwit@mail.ruhttps://orcid.org/0000-0001-9294-5447АчкасовС. И.AchkasovS. I.

Доктор медицинских наук, профессор, руководитель отдела онкологии и хирургии ободочной кишки, 5467-1062

ул.Саляма Адиля, д.2, г.Москва, 123423, Россия

info@gnck.ruhttps://orcid.org/0000-0001-9780-7916СушковО. И.SushkovO. I.

Кандидат медицинских наук, старший научный сотрудник отдела онкологии и хирургии ободочной кишки,7273-8489

ул.Саляма Адиля, д.2, г.Москва, 123423, Россия

info@gnck.ruhttps://orcid.org/0000-0001-8571-7462ЦукановА. С.TsukanovA. S.

Доктор медицинских наук, ведущий научный сотрудник отдела лабораторной генетики, 4005-0998

ул.Саляма Адиля, д.2, г.Москва, 123423, Россия

tsukanov81@rambler.ruФГБУ «НМИЦ колопроктологии имени А.Н. Рыжих» Минздрава РоссииРоссияRyzhikh National Medical Research Center of ColoproctologyRussian Federation202021122020194177187Copyright © Шубин В.П., Ачкасов С.И., Сушков О.И., Цуканов А.С., 20202020Шубин В.П., Ачкасов С.И., Сушков О.И., Цуканов А.С.Shubin V.P., Achkasov S.I., Sushkov O.I., Tsukanov A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.ruproctology.com/jour/article/view/1610ЦЕЛЬ

ЦЕЛЬ: провести анализ литературы, посвящённой молекулярно-генетическим особенностям у больных перитонеальным карциноматозом и метастазами рака толстой кишки в печень.

МАТЕРИАЛЫ И МЕТОДЫ

МАТЕРИАЛЫ И МЕТОДЫ: при подготовке обзора проанализированы статьи, имеющиеся в информационных базах биомедицинской литературы РИНЦ, Google Scoolar, PubMed, Web of Science. По теме исследования было проанализировано более 200 источников литературы, из которых 67 были включены в данный обзор.

РЕЗУЛЬТАТЫ

РЕЗУЛЬТАТЫ: в обзоре литературы рассмотрены данные о молекулярно-генетических изменениях, происходящих при реализации перитонеального карциноматоза и метастазов в печень у больных раком толстой кишки. Выделены ключевые моменты, на которые необходимо обратить внимание при назначении лечения больным метастатическим колоректальным раком.

ЗАКЛЮЧЕНИЕ

ЗАКЛЮЧЕНИЕ: представленные данные обобщают молекулярно-генетические исследования, позволяющие клиническим онкологам, хирургам и химиотерапевтам выбрать стратегию лечения.

AIM

AIM: to analyze the literature on the molecular genetic characteristics in patients with peritoneal carcinomatosis and liver metastases of colorectal cancer.

PATIENTS AND METHODS

PATIENTS AND METHODS: RSCI, Google Scoolar, PubMed, Web of Science databases were used for review. Over 200 literature sources on the given subject were analyzed, of which 67 were included in this review.

RESULTS

RESULTS: in the review, the data on molecular genetic changes occurring during peritoneal carcinomatosis and liver metastases in patients with colorectal cancer were presented. The key points for treatment patients with metastatic colorectal cancer were identified. 

CONCLUSION

CONCLUSION: the presented data summarizes molecular genetic studies, which in turn enable clinical oncologists, surgeons and chemotherapists to determine treatment modality.  

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The authors declare that there are no conflicts of interest present.