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<article article-type="editorial" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gnck</journal-id><journal-title-group><journal-title xml:lang="ru">Колопроктология</journal-title><trans-title-group xml:lang="en"><trans-title>Koloproktologia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-7556</issn><issn pub-type="epub">2686-7303</issn><publisher><publisher-name>Russian Association of Coloproctology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33878/2073-7556-2020-19-2-8-38</article-id><article-id custom-type="elpub" pub-id-type="custom">gnck-1579</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL GUIDELINES</subject></subj-group></article-categories><title-group><article-title>КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ ПО ДИАГНОСТИКЕ И ЛЕЧЕНИЮ БОЛЕЗНИ КРОНА У ВЗРОСЛЫХ (ПРОЕКТ)</article-title><trans-title-group xml:lang="en"><trans-title>CROHN'S DISEASE. CLINICAL RECOMMENDATIONS (PRELIMINARY VERSION)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Редакционная</surname><given-names>статья</given-names></name><name name-style="western" xml:lang="en"><surname>Editorial</surname><given-names>Article</given-names></name></name-alternatives></contrib></contrib-group><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>02</day><month>06</month><year>2020</year></pub-date><volume>19</volume><issue>2</issue><fpage>8</fpage><lpage>38</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Редакционная с., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Редакционная с.</copyright-holder><copyright-holder xml:lang="en">Editorial a.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ruproctology.com/jour/article/view/1579">https://www.ruproctology.com/jour/article/view/1579</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>болезнь Крона</kwd><kwd>воспалительные заболевания кишечника</kwd><kwd>консервативная терапия</kwd><kwd>хирургическое лечение</kwd><kwd>иммуносупрессоры</kwd><kwd>глюкокортикостероиды</kwd><kwd>биологическая терапия</kwd><kwd>противорецидивная терапия</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Sandborn WJ, Feagan BG, Hanauer SB, Lochs H, et al. A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn's disease. Gastroenterology 2002;122:512-30.</mixed-citation><mixed-citation xml:lang="en">Sandborn WJ, Feagan BG, Hanauer SB, Lochs H, et al. A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn's disease. Gastroenterology 2002;122:512-30.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Reinisch W, Rutgeerts P, Panaccione R, D'Haens G, et al. Identifying appropriate dichotomizing points for SES-CD to predict long-term clinical remission for adalimumab-treated patients with Crohn's disease. J Crohns Colitis. 2010;4:P045.</mixed-citation><mixed-citation xml:lang="en">Reinisch W, Rutgeerts P, Panaccione R, D'Haens G, et al. Identifying appropriate dichotomizing points for SES-CD to predict long-term clinical remission for adalimumab-treated patients with Crohn's disease. J Crohns Colitis. 2010;4:P045.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Воробьев Г.И., Халиф И.Л. Неспецифические воспалительные заболевания кишечника. Миклош, 2008.</mixed-citation><mixed-citation xml:lang="en">Vorobyov G.I., Khalif I.L. Inflammatory bowel diseases. Miklosh, 2008. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Khor B, Gardet A, Xavier RJ. Genetics and pathogenesis of inflammatory bowel disease. Nature. 2011;474:307-17.</mixed-citation><mixed-citation xml:lang="en">Khor B, Gardet A, Xavier RJ. Genetics and pathogenesis of inflammatory bowel disease. Nature. 2011;474:307-17.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Гастроэнтерология. Национальное руководство / Под ред. В.Т. Ивашкина, Т.Л. Лапиной. ГЭОТАР Медиа, 2008; 754 c.</mixed-citation><mixed-citation xml:lang="en">Ivashkin V.T., Lapina T.L. Gastroenterology. National recommendations. GEOTAR Media, 2008. 754p. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Cosnes J, Gower-Rousseau C, Seksik P, Cortot A. Epidemiology and natural history of infl ammatory bowel diseases. Gastroenterology. 2011;140:1785-94.</mixed-citation><mixed-citation xml:lang="en">Cosnes J, Gower-Rousseau C, Seksik P, Cortot A. Epidemiology and natural history of infl ammatory bowel diseases. Gastroenterology. 2011;140:1785-94.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Белоусова Е.А., Абдулганиева Д.И., Алексеева О.П., Алексеенко С.А., и соавт. Социально-демографическая характеристика, особенности течения и варианты лечения воспалительных заболеваний кишечника в России. Результаты двух многоцентровых исследований. Альманах клинической медицины. 2018;46(5):445-463. https://doi.org/10.18786/2072-05052018-46-5-445-463.</mixed-citation><mixed-citation xml:lang="en">Belousova E.A., Abdulganieva D.I., Alexeeva O.P., Alexeenko S.A., et al. Social and demographic characteristics, features of disease course and treatment options of inflammatory bowel disease in Russia: results of two multicenter studies. Almanac of Clinical Medicine. 2018; no. 46(5), pp. 445-463. https://doi.org/10.18786/2072-0505-2018-46-5-445-463. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Silverberg MS, Satsangi J, Ahmad T, Arnott ID, et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol. 2005;19(Suppl A): 5-36.</mixed-citation><mixed-citation xml:lang="en">Silverberg MS, Satsangi J, Ahmad T, Arnott ID, et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol. 2005;19(Suppl A): 5-36.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Cosnes J, Cattan S, Blain A, Beaugerie L, et al. Long-term evo lution of disease behavior of Crohn's disease. Inflamm Bowel Dis. 2002;8:244-50.</mixed-citation><mixed-citation xml:lang="en">Cosnes J, Cattan S, Blain A, Beaugerie L, et al. Long-term evo lution of disease behavior of Crohn's disease. Inflamm Bowel Dis. 2002;8:244-50.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Белоусова Е.А. Рекомендации по диагностике и лечению болезни Крона. Фарматека. 2009; № 13, c. 38-44.</mixed-citation><mixed-citation xml:lang="en">Belousova E.A. Recommendations for diagnosis and treatment of Crohn’s disease. Farmateka. 2009; no. 13, pp. 38-44. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Torres J, Bonovas S, Doherty G, Kucharzik T, et al. ECCO Guidelines on Therapeutics in Crohn's Disease: Medical Treatment. Journal of Crohn's and Colitis. 2020; 4(1): 4-22.</mixed-citation><mixed-citation xml:lang="en">Torres J, Bonovas S, Doherty G, Kucharzik T, et al. ECCO Guidelines on Therapeutics in Crohn's Disease: Medical Treatment. Journal of Crohn's and Colitis. 2020; 4(1): 4-22.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Best WR, Becktel JM, Singleton JW, Kern F Jr. Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterology. 1976 Mar;70(3):439-44.</mixed-citation><mixed-citation xml:lang="en">Best WR, Becktel JM, Singleton JW, Kern F Jr. Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterology. 1976 Mar;70(3):439-44.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Pimentel AM, Rocha R, Santana GO. Crohn’s disease of esophagus, stomach and duodenum. World J Gastrointest Pharmacol Ther. 2019; 10 (2): 35-49.</mixed-citation><mixed-citation xml:lang="en">Pimentel AM, Rocha R, Santana GO. Crohn’s disease of esophagus, stomach and duodenum. World J Gastrointest Pharmacol Ther. 2019; 10 (2): 35-49.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Григорьева Г.А., Мешалкина Н.Ю. О проблеме системных про явлений воспалительных заболеваний кишечника. Фарматека. 2011; № 15, c. 44-49.</mixed-citation><mixed-citation xml:lang="en">Grigoryeva G.A., Meshalkina N.Yu. A problem of systemic complications of inflammatory bowel diaseases. Farmateka. 2011; no. 15, pp. 44-49. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Щукина О.Б. Перианальная болезнь Крона: диагностика и медикаментозная терапия. Фарматека. 2008; № 13, c. 22-30.</mixed-citation><mixed-citation xml:lang="en">Schukina O.B. Perianal Crohn’s disease: diagnosis and medical treatment. Farmateka. 2008; no. 13, pp. 22-30. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Gecse KB, Bemelman W, Kamm MA, Stoker J, et al. A global consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease. Gut. 2014;63(9):1381-92.</mixed-citation><mixed-citation xml:lang="en">Gecse KB, Bemelman W, Kamm MA, Stoker J, et al. A global consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease. Gut. 2014;63(9):1381-92.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Steinhart AH, Panaccione R, Targownik L, et al. Clinical Practice Guideline for the Medical Management of Perianal Fistulizing Crohn's Disease: The Toronto Consensus . Inflamm Bowel Dis. 2019 Jan 1;25(1):1-13. doi: 10.1093/ibd/izy247.</mixed-citation><mixed-citation xml:lang="en">Steinhart AH, Panaccione R, Targownik L, et al. Clinical Practice Guideline for the Medical Management of Perianal Fistulizing Crohn's Disease: The Toronto Consensus . Inflamm Bowel Dis. 2019 Jan 1;25(1):1-13. doi: 10.1093/ibd/izy247.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Horsthuis K, Bipat S, Bennink RJ, Stoker J. Inflammatory bowel disease diagnosed with US, MR, scintigraphy, and CT: metaanalysis of prospective studies. Radiology. 2008;247(1):64-79.</mixed-citation><mixed-citation xml:lang="en">Horsthuis K, Bipat S, Bennink RJ, Stoker J. Inflammatory bowel disease diagnosed with US, MR, scintigraphy, and CT: metaanalysis of prospective studies. Radiology. 2008;247(1):64-79.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Чашкова Е.Ю., Владимирова А.А., Неустроев В.Г. и соавт. Воспалительные заболевания толстой кишки – аспекты диагностики. Бюллетень Восточно-Сибирского научного центра СОРАМН. 2011; № 4-2, c. 209-221.</mixed-citation><mixed-citation xml:lang="en">Chashkova E.Yu., Vladimirova A.A., Neustroyev V.G., et al. Inflammatory bowel diseases – aspects of diagnosis. Acta Biomedica Scientifica. 2011; no. 4, pp. 209-211.(In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Lennard-Jones JE. Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl. 1989;170:2-6.</mixed-citation><mixed-citation xml:lang="en">Lennard-Jones JE. Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl. 1989;170:2-6.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Справочник по колопроктологии под редакцией проф. Ю.А. Шелыгина, проф Л.А. Благодарного. «Литтерра», 2012; c. 460-522.</mixed-citation><mixed-citation xml:lang="en">Shelygin Yu.A., Blagodarny L.A. Reference book on coloproctology. Litterra. 2012:460-522. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Lucendo AJ, Arias Á , Roncero Ó, Hervías D, et al. Anemia at the time of diagnosis of inflammatory bowel disease: Prevalence and associated factors in adolescent and adult patients . Sao Paulo Med J. 2014;132(3):140-6.</mixed-citation><mixed-citation xml:lang="en">Lucendo AJ, Arias Á , Roncero Ó, Hervías D, et al. Anemia at the time of diagnosis of inflammatory bowel disease: Prevalence and associated factors in adolescent and adult patients . Sao Paulo Med J. 2014;132(3):140-6.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Irwin JR, Ferguson E, Simms LA, Hanigan K, et al. Detectable Laboratory Abnormality Is Present up to 12 Months Prior to Diagnosis in Patients with Crohn's Disease. Dig Dis Sci. 2019 Feb;64(2):503-517.</mixed-citation><mixed-citation xml:lang="en">Irwin JR, Ferguson E, Simms LA, Hanigan K, et al. Detectable Laboratory Abnormality Is Present up to 12 Months Prior to Diagnosis in Patients with Crohn's Disease. Dig Dis Sci. 2019 Feb;64(2):503-517.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Feng JR, Qiu X, Wang F, Chen PF, et al. Diagnostic Value of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Crohn's Disease. Gastroenterol Res Pract. 2017;2017:3526460. doi: 10.1155/2017/3526460.</mixed-citation><mixed-citation xml:lang="en">Feng JR, Qiu X, Wang F, Chen PF, et al. Diagnostic Value of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Crohn's Disease. Gastroenterol Res Pract. 2017;2017:3526460. doi: 10.1155/2017/3526460.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Archampong EQ, Harris J, Clark CG. The absorption and secretion of water and electrolytes across the healthy and the diseased human colonic mucosa measured in vitro. Gut. 1972 Nov;13(11):880-6.</mixed-citation><mixed-citation xml:lang="en">Archampong EQ, Harris J, Clark CG. The absorption and secretion of water and electrolytes across the healthy and the diseased human colonic mucosa measured in vitro. Gut. 1972 Nov;13(11):880-6.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Maharshak N, Arbel Y, Gal-Oz A, Rogowski O, et al. Comparative analysis of Bayer wide-range C-reactive protein (wr-CRP) and the Dade-Behring high sensitivity C-reactive protein (hs-CRP) in patients with inflammatory bowel disease. J Dig Dis. 2008 Aug;9(3):140-3.</mixed-citation><mixed-citation xml:lang="en">Maharshak N, Arbel Y, Gal-Oz A, Rogowski O, et al. Comparative analysis of Bayer wide-range C-reactive protein (wr-CRP) and the Dade-Behring high sensitivity C-reactive protein (hs-CRP) in patients with inflammatory bowel disease. J Dig Dis. 2008 Aug;9(3):140-3.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Weber P, Husemann S, Vielhaber H, Zimmer KP, et al. Coagulation and fibrinolysis in children, adolescents, and young adults with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 1999 Apr;28(4):418-22.</mixed-citation><mixed-citation xml:lang="en">Weber P, Husemann S, Vielhaber H, Zimmer KP, et al. Coagulation and fibrinolysis in children, adolescents, and young adults with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 1999 Apr;28(4):418-22.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Vermeire S, Van Assche G, Rutgeerts P. C-reactive protein as a marker for inflammatory bowel disease. Inflamm Bowel Dis. 2004;10:661-665.</mixed-citation><mixed-citation xml:lang="en">Vermeire S, Van Assche G, Rutgeerts P. C-reactive protein as a marker for inflammatory bowel disease. Inflamm Bowel Dis. 2004;10:661-665.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">D'Inca R, Dal Pont E, Di Leo V, et al. Calprotectin and lactoferrin in the assessment of intestinal inflammation and organic disease. Int J Colorectal Dis. 2007;22:429-37.</mixed-citation><mixed-citation xml:lang="en">D'Inca R, Dal Pont E, Di Leo V, et al. Calprotectin and lactoferrin in the assessment of intestinal inflammation and organic disease. Int J Colorectal Dis. 2007;22:429-37.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Issa M, Vikayapal A, Gracham MB et al. Impact of Clostridium difficile in inflammatory bowel disease patients. Clin Gastroenterol Hepatol. 2007; 5: 345-351.</mixed-citation><mixed-citation xml:lang="en">Issa M, Vikayapal A, Gracham MB et al. Impact of Clostridium difficile in inflammatory bowel disease patients. Clin Gastroenterol Hepatol. 2007; 5: 345-351.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Rodeman JF, Dubberke ER, Reske KA et al. Incidence of Clostridium difficile in inflammatory bowel disease. Clin Gastroenterol Hepatol. 2007; 5: 339-344.</mixed-citation><mixed-citation xml:lang="en">Rodeman JF, Dubberke ER, Reske KA et al. Incidence of Clostridium difficile in inflammatory bowel disease. Clin Gastroenterol Hepatol. 2007; 5: 339-344.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Issa M, Ananthakrishnan AN, Binion DG. Clostridium difficile and inflammatory bowel disease. Inflamm Bowel Dis. 2008; 14:1432-42.</mixed-citation><mixed-citation xml:lang="en">Issa M, Ananthakrishnan AN, Binion DG. Clostridium difficile and inflammatory bowel disease. Inflamm Bowel Dis. 2008; 14:1432-42.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Nguyen GC, Kaplan GG, Harris ML et al. A national survey of the prevalence and impact of Clostridium difficile infection among hospitalized inflammatory bowel disease patients. Am J Gastroenterol. 2008; 103: 1443-50.</mixed-citation><mixed-citation xml:lang="en">Nguyen GC, Kaplan GG, Harris ML et al. A national survey of the prevalence and impact of Clostridium difficile infection among hospitalized inflammatory bowel disease patients. Am J Gastroenterol. 2008; 103: 1443-50.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Issa M, Ananthakrishnan AN, Binion DG. Clostridium difficile and inflammatory bowel disease. Inflamm Bowel Dis. 2008; 14:1432-42.</mixed-citation><mixed-citation xml:lang="en">Issa M, Ananthakrishnan AN, Binion DG. Clostridium difficile and inflammatory bowel disease. Inflamm Bowel Dis. 2008; 14:1432-42.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Nguyen GC, Kaplan GG, Harris ML et al. A national survey of the prevalence and impact of Clostridium difficile infection among hospitalized inflammatory bowel disease patients. Am J Gastroenterol. 2008; 103: 1443-50.</mixed-citation><mixed-citation xml:lang="en">Nguyen GC, Kaplan GG, Harris ML et al. A national survey of the prevalence and impact of Clostridium difficile infection among hospitalized inflammatory bowel disease patients. Am J Gastroenterol. 2008; 103: 1443-50.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Mylonaki M, Langmead L, Pantes A, et al. Enteric infection in relapse of inflammatory bowel disease: importance of micro biological examination of stool. Eur J Gastroenterol Hepatol. 2004;16:775-8.</mixed-citation><mixed-citation xml:lang="en">Mylonaki M, Langmead L, Pantes A, et al. Enteric infection in relapse of inflammatory bowel disease: importance of microbiological examination of stool. Eur J Gastroenterol Hepatol. 2004;16:775-8.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Axelrad JE1, Joelson A, Green PHR, Lawlor G, et al. Enteric Infections Are Common in Patients with Flares of Inflammatory Bowel Disease. Am J Gastroenterol. 2018 Oct;113(10):1530-1539. doi: 10.1038/s41395-018-0211-8.</mixed-citation><mixed-citation xml:lang="en">Axelrad JE1, Joelson A, Green PHR, Lawlor G, et al. Enteric Infections Are Common in Patients with Flares of Inflammatory Bowel Disease. Am J Gastroenterol. 2018 Oct;113(10):1530-1539. doi: 10.1038/s41395-018-0211-8.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Nolan DJ. Radiology of inflammatory bowel disease. Br J Hosp Med. 1986 Aug;36(2):128-32.</mixed-citation><mixed-citation xml:lang="en">Nolan DJ. Radiology of inflammatory bowel disease. Br J Hosp Med. 1986 Aug;36(2):128-32.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Long B, Robertson J, Koyfman A. Emergency Medicine Evaluation and Management of Small Bowel Obstruction: EvidenceBased Recommendations. J Emerg Med. 2019 Feb;56(2):166-176. doi: 10.1016/j.jemermed.2018.10.024. Epub 2018 Dec 6.</mixed-citation><mixed-citation xml:lang="en">Long B, Robertson J, Koyfman A. Emergency Medicine Evaluation and Management of Small Bowel Obstruction: EvidenceBased Recommendations. J Emerg Med. 2019 Feb;56(2):166-176. doi: 10.1016/j.jemermed.2018.10.024. Epub 2018 Dec 6.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Coremans G, Rutgeerts P, Geboes K, et al. The value of ileoscopy with biopsy in the diagnosis of intestinal Crohn's disease. Gastrointest Endosc. 1984;30:167-72.</mixed-citation><mixed-citation xml:lang="en">Coremans G, Rutgeerts P, Geboes K, et al. The value of ileoscopy with biopsy in the diagnosis of intestinal Crohn's disease. Gastrointest Endosc. 1984;30:167-72.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Annese V, Daperno M, Rutter MD, et al. European evidence based consensus for endoscopy in inflammatory bowel disease. J Crohns Colitis. 2013;7:982-1018.</mixed-citation><mixed-citation xml:lang="en">Annese V, Daperno M, Rutter MD, et al. European evidence based consensus for endoscopy in inflammatory bowel disease. J Crohns Colitis. 2013;7:982-1018.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Cameron DJ. Upper and lower gastrointestinal endoscopy in children and adolescents with Crohn's disease: a prospective study. J Gastroenterol Hepatol. 1991 Jul-Aug;6(4):355-8.</mixed-citation><mixed-citation xml:lang="en">Cameron DJ. Upper and lower gastrointestinal endoscopy in children and adolescents with Crohn's disease: a prospective study. J Gastroenterol Hepatol. 1991 Jul-Aug;6(4):355-8.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Annunziata ML, Caviglia R, Papparella LG. Cicala M. Upper gastrointestinal involvement of Crohn's disease: a prospective study on the role of upper endoscopy in the diagnostic work-up. Dig Dis Sci. 2012;57:1618-1623.</mixed-citation><mixed-citation xml:lang="en">Annunziata ML, Caviglia R, Papparella LG. Cicala M. Upper gastrointestinal involvement of Crohn's disease: a prospective study on the role of upper endoscopy in the diagnostic work-up. Dig Dis Sci. 2012;57:1618-1623.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Gourtsoyiannis NC, Grammatikakis J, Papamastorakis G, et al. Imaging of small intestinal Crohn's disease: comparison between MR enteroclysis and conventional enteroclysis. Eur Radiol. 2006;16:1915-25.</mixed-citation><mixed-citation xml:lang="en">Gourtsoyiannis NC, Grammatikakis J, Papamastorakis G, et al. Imaging of small intestinal Crohn's disease: comparison between MR enteroclysis and conventional enteroclysis. Eur Radiol. 2006;16:1915-25.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Bettenworth D, Bokemeyer A, Baker M, Mao R, et al. Assessment of Crohn's disease-associated small bowel strictures and fibrosis on cross-sectional imaging: a systematic review. Gut. 2019 June; 68(6):1115-1126.</mixed-citation><mixed-citation xml:lang="en">Bettenworth D, Bokemeyer A, Baker M, Mao R, et al. Assessment of Crohn's disease-associated small bowel strictures and fibrosis on cross-sectional imaging: a systematic review. Gut. 2019 June; 68(6):1115-1126.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Chidi VN, Schwartz DA. Imaging of perianal fistulizing Crohn's disease. Expert Rev Gastroenterol Hepatol. 2015 Jun;9(6):797-806. doi: 10.1586/17474124.2015.1031110. Epub 2015 Mar 30.</mixed-citation><mixed-citation xml:lang="en">Chidi VN, Schwartz DA. Imaging of perianal fistulizing Crohn's disease. Expert Rev Gastroenterol Hepatol. 2015 Jun;9(6):797-806. doi: 10.1586/17474124.2015.1031110. Epub 2015 Mar 30.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Sheedy SP, Bruining DH, Dozois EJ, Faubion WA, et al. MR Imaging of Perianal Crohn Disease. Radiology. 2017 Mar;282(3):628-645. doi: 10.1148/radiol.2016151491.</mixed-citation><mixed-citation xml:lang="en">Sheedy SP, Bruining DH, Dozois EJ, Faubion WA, et al. MR Imaging of Perianal Crohn Disease. Radiology. 2017 Mar;282(3):628-645. doi: 10.1148/radiol.2016151491.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Gasche C, Schober E, Turetschek K. Small bowel barium studies in Crohn's disease. Gastroenterology. 1998 Jun;114(6):1349.</mixed-citation><mixed-citation xml:lang="en">Gasche C, Schober E, Turetschek K. Small bowel barium studies in Crohn's disease. Gastroenterology. 1998 Jun;114(6):1349.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Nolan DJ, Piris J. Crohn's disease of the small intestine: a comparative study of the radiological and pathological appearances. Clin Radiol. 1980 Sep;31(5):591-6.</mixed-citation><mixed-citation xml:lang="en">Nolan DJ, Piris J. Crohn's disease of the small intestine: a comparative study of the radiological and pathological appearances. Clin Radiol. 1980 Sep;31(5):591-6.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Портной Л.М., Исаков В.А., Казанцева И.А. Современная лучевая диагностика болезни Крона тонкой кишки. Вестник рентгенол., радиол. 2001; № 5. c. 10-16.</mixed-citation><mixed-citation xml:lang="en">Portnoi L., Isakov V., Kazantseva I., Petukhova N., et al. Current x-ray diagnosis of Crohn's disease of the small intestine. Vestn Rentgenol Radiol. 2001 Sep-Oct;(5):33-40. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Тертычный А.С., Андреев А.И., Гебоэс К. Современные подходы к морфологической диагностике воспалительных заболеваний кишечника на материале эндоскопических биопсий. Архив патологии. 2011; т. 73; № 1, c. 40-47.</mixed-citation><mixed-citation xml:lang="en">Tertychny A.S., Andreev A.I., Geboes K. Modern approaches to the morphological diagnosis of inflammatory bowel diseases using endoscopic biopsies. Arkhiv patologii. 2011; no. 73(1), pp. 40-47. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Fraquelli M, Colli A, Casazza G, et al. Role of US in detection of Crohn disease: meta-analysis. Radiology. 2005;236:95-101.</mixed-citation><mixed-citation xml:lang="en">Fraquelli M, Colli A, Casazza G, et al. Role of US in detection of Crohn disease: meta-analysis. Radiology. 2005;236:95-101.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Воробьев Г.И., Орлова Л.П., Самсонова Т.В., Капуллер Л.Л., и соавт. Возможности ультразвукового исследования в диагностике болезни крона. Ультразвуковая и функциональная диагностика. 2010; № 1, c. 29-36.</mixed-citation><mixed-citation xml:lang="en">Vorobyov G.I., Orlova L.P., Samsonova T.V., Kapuller L.L. et al. The possibilities of ultrasound in the diagnosis of Crohn's disease. Ultrasound and functional diagnostics. 2010; no. 1, pp. 29-36. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Самсонова Т.В., Орлова Л.П. Ультразвуковая семиотика болезни Крона тонкой кишки. Колопроктология. 2014; № 1(47), c. 60-68.</mixed-citation><mixed-citation xml:lang="en">Samsonova T.V., Orlova L.P.Ultrasonic imaging peculiarities of small intestine crohn's disease. Koloproktologia. 2014; no. 1(47), pp. 60-68. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Dionisio PM, Gurudu SR, Leighton JA, Leontiadis GI, et al. Capsule endoscopy has a significantly higher diagnostic yield in patients with suspected and established small-bowel Crohn's disease: a meta-analysis. Am J Gastroenterol. 2010;105:1240-1248 [quiz 1249].</mixed-citation><mixed-citation xml:lang="en">Dionisio PM, Gurudu SR, Leighton JA, Leontiadis GI, et al. Capsule endoscopy has a significantly higher diagnostic yield in patients with suspected and established small-bowel Crohn's disease: a meta-analysis. Am J Gastroenterol. 2010;105:1240-1248 [quiz 1249].</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Spada C, Riccioni ME, Costamagna G. Patients with known small bowel stricture or with symptoms of small bowel obstruction secondary to Crohn’s disease should not perform video capsule endoscopy without previously tested for small bowel patency. Am J Gastroenterol. 2007; 102:1542-3.</mixed-citation><mixed-citation xml:lang="en">Spada C, Riccioni ME, Costamagna G. Patients with known small bowel stricture or with symptoms of small bowel obstruction secondary to Crohn’s disease should not perform video capsule endoscopy without previously tested for small bowel patency. Am J Gastroenterol. 2007; 102:1542-3.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Spada C, Shah SK, Riccioni ME et al. Video capsule endoscopy in patients with known or suspected small bowel stricture previously tested with the dissolving patency capsule. J Clin Gastroenterol. 2007; 42:576-82.</mixed-citation><mixed-citation xml:lang="en">Spada C, Shah SK, Riccioni ME et al. Video capsule endoscopy in patients with known or suspected small bowel stricture previously tested with the dissolving patency capsule. J Clin Gastroenterol. 2007; 42:576-82.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Schulz C, Mönkemüller K, Salheiser M, et al. Double-balloon enteroscopy in the diagnosis of suspected isolated Crohn's disease of the small bowel. Dig Endosc. 2014 Mar;26(2):236-42. doi: 10.1111/den.12142. Epub 2013 Jul 16.</mixed-citation><mixed-citation xml:lang="en">Schulz C, Mönkemüller K, Salheiser M, et al. Double-balloon enteroscopy in the diagnosis of suspected isolated Crohn's disease of the small bowel. Dig Endosc. 2014 Mar;26(2):236-42. doi: 10.1111/den.12142. Epub 2013 Jul 16.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">American Gastroenterological Association medical position statement: guidelines for the evaluation and management of chronic diarrhea. Gastroenterology. 1999;116(6):1461-3.</mixed-citation><mixed-citation xml:lang="en">American Gastroenterological Association medical position statement: guidelines for the evaluation and management of chronic diarrhea. Gastroenterology. 1999;116(6):1461-3.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Корнеева О.И., Ивашкин В.Т. Антибиотико-ассоциированный колит: патоморфология, клиника, лечение. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2007; т. 17, № 3, c. 65-71.</mixed-citation><mixed-citation xml:lang="en">Korneeva O.I., Ivashkin V.T. Antibiotic-associated colitis: pathomorphology, clinic, treatment. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2007; no. 17(3), pp. 65-71. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Coward S, Kuenzig ME, Hazlewood G, Clement F, et al.Comparative Effectiveness of Mesalamine, Sulfasalazine, Corticosteroids, and Budesonide for the Induction of Remission in Crohn's Disease: A Bayesian Network Meta-analysis. Inflamm Bowel Dis. 2017 Mar;23(3):461-472. doi: 10.1097/MIB.0000000000001023.</mixed-citation><mixed-citation xml:lang="en">Coward S, Kuenzig ME, Hazlewood G, Clement F, et al.Comparative Effectiveness of Mesalamine, Sulfasalazine, Corticosteroids, and Budesonide for the Induction of Remission in Crohn's Disease: A Bayesian Network Meta-analysis. Inflamm Bowel Dis. 2017 Mar;23(3):461-472. doi: 10.1097/MIB.0000000000001023.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Rezaie A, Kuenzig ME, Benchimol EI, Griffiths AM, et al. Budesonide for induction of remission in Crohn's disease. Cochrane Database Syst Rev. 2015 Jun 3;(6):CD000296. doi: 10.1002/14651858.CD000296.pub4.</mixed-citation><mixed-citation xml:lang="en">Rezaie A, Kuenzig ME, Benchimol EI, Griffiths AM, et al. Budesonide for induction of remission in Crohn's disease. Cochrane Database Syst Rev. 2015 Jun 3;(6):CD000296. doi: 10.1002/14651858.CD000296.pub4.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Carter MJ, Lobo AJ, Travis SP. IBD Section, British Society of Gastroenterology. Guidelines for the management of inflammatory bowel disease in adults. Gut. 2004;53(Suppl 5):V1-V16.</mixed-citation><mixed-citation xml:lang="en">Carter MJ, Lobo AJ, Travis SP. IBD Section, British Society of Gastroenterology. Guidelines for the management of inflammatory bowel disease in adults. Gut. 2004;53(Suppl 5):V1-V16.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Tay GS, Binion DG, Eastwood D, Otterson MF. Multivariate analysis suggests improved perioperative outcome in Crohn's disease patients receiving immunomodulator therapy after segmental resection and/or strictureplasty. Surgery. 2003;34:565-72 discussion 572-3.97.</mixed-citation><mixed-citation xml:lang="en">Tay GS, Binion DG, Eastwood D, Otterson MF. Multivariate analysis suggests improved perioperative outcome in Crohn's disease patients receiving immunomodulator therapy after segmental resection and/or strictureplasty. Surgery. 2003;34:565-72 discussion 572-3.97.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Steinhart AH, Ewe K, Griffiths AM, Modigliani R, Thomsen OO. Corticosteroids for maintaining remission of Crohn's disease. Cochrane Database Syst Rev. 2003(4):CD000301.</mixed-citation><mixed-citation xml:lang="en">Steinhart AH, Ewe K, Griffiths AM, Modigliani R, Thomsen OO. Corticosteroids for maintaining remission of Crohn's disease. Cochrane Database Syst Rev. 2003(4):CD000301.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Seow CH, Benchimol EI, Griffiths AM, et al. Budesonide for induction of remission in Crohn's disease. Cochrane Database Syst Rev. 2008:CD000296.</mixed-citation><mixed-citation xml:lang="en">Seow CH, Benchimol EI, Griffiths AM, et al. Budesonide for induction of remission in Crohn's disease. Cochrane Database Syst Rev. 2008:CD000296.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Chande N, Townsend CM, Parker CE, MacDonald JK. Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease. Cochrane Database Syst Rev. 2016 Oct 26;10:CD000545.</mixed-citation><mixed-citation xml:lang="en">Chande N, Townsend CM, Parker CE, MacDonald JK. Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease. Cochrane Database Syst Rev. 2016 Oct 26;10:CD000545.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Herfarth HH, Kappelman MD, Long MD, et al. Use of Methotrexate in the Treatment of Inflammatory Bowel Diseases. Inflamm Bowel Dis. 2016;22:224-33.</mixed-citation><mixed-citation xml:lang="en">Herfarth HH, Kappelman MD, Long MD, et al. Use of Methotrexate in the Treatment of Inflammatory Bowel Diseases. Inflamm Bowel Dis. 2016;22:224-33.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">McDonald JW1, Wang Y, Tsoulis DJ, MacDonald JK, et al. Methotrexate for induction of remission in refractory Crohn's disease. Cochrane Database Syst Rev. 2014 Aug 6;(8):CD003459. doi: 10.1002/14651858.CD003459.pub4.</mixed-citation><mixed-citation xml:lang="en">McDonald JW1, Wang Y, Tsoulis DJ, MacDonald JK, et al. Methotrexate for induction of remission in refractory Crohn's disease. Cochrane Database Syst Rev. 2014 Aug 6;(8):CD003459. doi: 10.1002/14651858.CD003459.pub4.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Pearson DC, May GR, Fick GR, Sutherland LR. Azathioprine for maintaining remission of Crohn's disease. Cochrane Database Syst Rev. 2000(2):CD000067.</mixed-citation><mixed-citation xml:lang="en">Pearson DC, May GR, Fick GR, Sutherland LR. Azathioprine for maintaining remission of Crohn's disease. Cochrane Database Syst Rev. 2000(2):CD000067.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Chande N, Patton PH, Tsoulis DJ, Thomas BS, et al. Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev. 2015 Oct 30;(10):CD000067.</mixed-citation><mixed-citation xml:lang="en">Chande N, Patton PH, Tsoulis DJ, Thomas BS, et al. Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev. 2015 Oct 30;(10):CD000067.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Qiu Y, Chen BL, Feng R, Zhang SH, et al. Prolonged azathioprine treatment reduces the need for surgery in early Crohn's disease. J Gastroenterol Hepatol. 2018 Mar;33(3):664-670. doi: 10.1111/jgh.14000.</mixed-citation><mixed-citation xml:lang="en">Qiu Y, Chen BL, Feng R, Zhang SH, et al. Prolonged azathioprine treatment reduces the need for surgery in early Crohn's disease. J Gastroenterol Hepatol. 2018 Mar;33(3):664-670. doi: 10.1111/jgh.14000.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Benchimol EI, Seow CH, Steinhart AH, Griffiths AM. Traditional corticosteroids for induction of remission in Crohn's disease. Cochrane Database Syst Rev. 2008;2:CD006792.</mixed-citation><mixed-citation xml:lang="en">Benchimol EI, Seow CH, Steinhart AH, Griffiths AM. Traditional corticosteroids for induction of remission in Crohn's disease. Cochrane Database Syst Rev. 2008;2:CD006792.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Ho GT, Chiam P, Drummond H, Loane J, et al. The efficacy of corticosteroid therapy in inflammatory bowel disease: analysis of a 5-year UK inception cohort. Aliment Pharmacol Ther. 2006;24:319-30.</mixed-citation><mixed-citation xml:lang="en">Ho GT, Chiam P, Drummond H, Loane J, et al. The efficacy of corticosteroid therapy in inflammatory bowel disease: analysis of a 5-year UK inception cohort. Aliment Pharmacol Ther. 2006;24:319-30.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Frey BM, Frey FJ. Clinical pharmacokinetics of prednisone and prednisolone. Clin Pharmacokinet. 1990 Aug;19(2):126-46.</mixed-citation><mixed-citation xml:lang="en">Frey BM, Frey FJ. Clinical pharmacokinetics of prednisone and prednisolone. Clin Pharmacokinet. 1990 Aug;19(2):126-46.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Khan KJ, Ullman TA, Ford AC, Abreu MT, et al. Antibiotic therapy in inflammatory bowel disease: a systematic review and metaanalysis. Am J Gastroenterol. 2011;106:661-73.</mixed-citation><mixed-citation xml:lang="en">Khan KJ, Ullman TA, Ford AC, Abreu MT, et al. Antibiotic therapy in inflammatory bowel disease: a systematic review and metaanalysis. Am J Gastroenterol. 2011;106:661-73.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Ohkusa T, Kato K, Terao S, Chiba T, et al. Newly developed antibiotic combination therapy for ulcerative colitis: a doubleblind placebo-controlled multicenter trial. Am J Gastroenterol. 2010;105:1820-9.</mixed-citation><mixed-citation xml:lang="en">Ohkusa T, Kato K, Terao S, Chiba T, et al. Newly developed antibiotic combination therapy for ulcerative colitis: a doubleblind placebo-controlled multicenter trial. Am J Gastroenterol. 2010;105:1820-9.</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Ledder O, Turner D. Antibiotics in IBD: Still a Role in the Biological Era? Inflamm Bowel Dis. 2018 Jul 12;24(8):1676-1688.</mixed-citation><mixed-citation xml:lang="en">Ledder O, Turner D. Antibiotics in IBD: Still a Role in the Biological Era? Inflamm Bowel Dis. 2018 Jul 12;24(8):1676-1688.</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Prantera C, Zannoni F, Scribano ML, et al. An antibiotic regimen for the treatment of active Crohn's disease: a randomized, controlled clinical trial of metronidazole plus ciprofloxacin. Am J Gastroenterol. 1996;91:328-32</mixed-citation><mixed-citation xml:lang="en">Prantera C, Zannoni F, Scribano ML, et al. An antibiotic regimen for the treatment of active Crohn's disease: a randomized, controlled clinical trial of metronidazole plus ciprofloxacin. Am J Gastroenterol. 1996;91:328-32</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Hazlewood GS, Rezaie A, Borman M, et al. Comparative effectiveness of immunosuppressants and biologics for inducing and maintaining remission in Crohn's disease: a network meta-analysis. Gastroenterology. 2015 Feb;148(2):344-54.</mixed-citation><mixed-citation xml:lang="en">Hazlewood GS, Rezaie A, Borman M, et al. Comparative effectiveness of immunosuppressants and biologics for inducing and maintaining remission in Crohn's disease: a network meta-analysis. Gastroenterology. 2015 Feb;148(2):344-54.</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Singh S, Fumery M, Sandborn WJ, Murad MH. Systematic review and network meta-analysis: first- and second-line biologic therapies for moderate-severe Crohn's disease. Aliment Pharmacol Ther. 2018 Aug;48(4):394-409.</mixed-citation><mixed-citation xml:lang="en">Singh S, Fumery M, Sandborn WJ, Murad MH. Systematic review and network meta-analysis: first- and second-line biologic therapies for moderate-severe Crohn's disease. Aliment Pharmacol Ther. 2018 Aug;48(4):394-409.</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Cholapranee A, Hazlewood GS, Kaplan GG, et al. Systematic review with meta-analysis: comparative efficacy of biologics for induction and maintenance of mucosal healing in Crohn's disease and ulcerative colitis controlled trials. Aliment Pharmacol Ther. 2017 May;45(10):1291-1302.</mixed-citation><mixed-citation xml:lang="en">Cholapranee A, Hazlewood GS, Kaplan GG, et al. Systematic review with meta-analysis: comparative efficacy of biologics for induction and maintenance of mucosal healing in Crohn's disease and ulcerative colitis controlled trials. Aliment Pharmacol Ther. 2017 May;45(10):1291-1302.</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">Hazlewood GS, Rezaie A, Borman M, Panaccione R, et al. Comparative effectiveness of immunosuppressants and biologics for inducing and maintaining remission in Crohn's disease: a network meta-analysis. Aliment Pharmacol Ther. 2017 May;45(10):12911302. doi: 10.1111/apt.14030. Epub 2017 Mar 22.</mixed-citation><mixed-citation xml:lang="en">Hazlewood GS, Rezaie A, Borman M, Panaccione R, et al. Comparative effectiveness of immunosuppressants and biologics for inducing and maintaining remission in Crohn's disease: a network meta-analysis. Aliment Pharmacol Ther. 2017 May;45(10):12911302. doi: 10.1111/apt.14030. Epub 2017 Mar 22.</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">Behm BW, Bickston SJ. Tumor necrosis factor-alpha antibody for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev. 2009;1:CD006893.</mixed-citation><mixed-citation xml:lang="en">Behm BW, Bickston SJ. Tumor necrosis factor-alpha antibody for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev. 2009;1:CD006893.</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">Sandborn WJ, Feagan BG, Rutgeerts P, Hanauer S, et al. Vedolizumab as induction and maintenance therapy for Crohn's disease. N Engl J Med. 2013 Aug 22;369(8):711-21. doi: 10.1056/NEJMoa1215739.</mixed-citation><mixed-citation xml:lang="en">Sandborn WJ, Feagan BG, Rutgeerts P, Hanauer S, et al. Vedolizumab as induction and maintenance therapy for Crohn's disease. N Engl J Med. 2013 Aug 22;369(8):711-21. doi: 10.1056/NEJMoa1215739.</mixed-citation></citation-alternatives></ref><ref id="cit86"><label>86</label><citation-alternatives><mixed-citation xml:lang="ru">Feagan BG, Sandborn WJ, Gasink C, Jacobstein D, et al. Ustekinumab as Induction and Maintenance Therapy for Crohn's Disease. N Engl J Med. 2016 Nov 17;375(20):1946-1960.</mixed-citation><mixed-citation xml:lang="en">Feagan BG, Sandborn WJ, Gasink C, Jacobstein D, et al. Ustekinumab as Induction and Maintenance Therapy for Crohn's Disease. N Engl J Med. 2016 Nov 17;375(20):1946-1960.</mixed-citation></citation-alternatives></ref><ref id="cit87"><label>87</label><citation-alternatives><mixed-citation xml:lang="ru">Colombel JF, Sandborn WJ, Reinisch W, et al. Infliximab, azathioprine, or combination therapy for Crohn's disease. N Engl J Med. 2010;362:1383-95.</mixed-citation><mixed-citation xml:lang="en">Colombel JF, Sandborn WJ, Reinisch W, et al. Infliximab, azathioprine, or combination therapy for Crohn's disease. N Engl J Med. 2010;362:1383-95.</mixed-citation></citation-alternatives></ref><ref id="cit88"><label>88</label><citation-alternatives><mixed-citation xml:lang="ru">Lémann M, Mary JY, Duclos B, et al. Infliximab plus azathio prine for steroid-dependent Crohn's disease patients: a randomized placebo-controlled trial. Gastroenterology. 2006;130:1054-61.</mixed-citation><mixed-citation xml:lang="en">Lémann M, Mary JY, Duclos B, et al. Infliximab plus azathio prine for steroid-dependent Crohn's disease patients: a randomized placebo-controlled trial. Gastroenterology. 2006;130:1054-61.</mixed-citation></citation-alternatives></ref><ref id="cit89"><label>89</label><citation-alternatives><mixed-citation xml:lang="ru">Colombel JF, Rutgeerts P, Reinisch W, et al. SONIC: a randomized, double blind, controlled trial comparing infliximab and infliximab plus azathioprine to azathioprine in patients with Crohn's disease naïve to immunomodulators and biologic therapy. Gut. 2008;57 Suppl II:A1.</mixed-citation><mixed-citation xml:lang="en">Colombel JF, Rutgeerts P, Reinisch W, et al. SONIC: a randomized, double blind, controlled trial comparing infliximab and infliximab plus azathioprine to azathioprine in patients with Crohn's disease naïve to immunomodulators and biologic therapy. Gut. 2008;57 Suppl II:A1.</mixed-citation></citation-alternatives></ref><ref id="cit90"><label>90</label><citation-alternatives><mixed-citation xml:lang="ru">Colombel JF, Adedokun OJ, Gasink C, Gao LL, et al. Combination Therapy With Infliximab and Azathioprine Improves Infliximab Pharmacokinetic Features and Efficacy: A Post Hoc Analysis. Clin Gastroenterol Hepatol. 2019 Jul;17(8):1525-1532.e1. doi: 10.1016/j.cgh.2018.09.033. Epub 2018 Sep 26.</mixed-citation><mixed-citation xml:lang="en">Colombel JF, Adedokun OJ, Gasink C, Gao LL, et al. Combination Therapy With Infliximab and Azathioprine Improves Infliximab Pharmacokinetic Features and Efficacy: A Post Hoc Analysis. Clin Gastroenterol Hepatol. 2019 Jul;17(8):1525-1532.e1. doi: 10.1016/j.cgh.2018.09.033. Epub 2018 Sep 26.</mixed-citation></citation-alternatives></ref><ref id="cit91"><label>91</label><citation-alternatives><mixed-citation xml:lang="ru">Singh S, George J, Boland BS, Vande Casteele N, et al. Primary Non-Response to Tumor Necrosis Factor Antagonists is Associated with Inferior Response to Second-line Biologics in Patients with Inflammatory Bowel Diseases: A Systematic Review and Metaanalysis. J Crohns Colitis. 2018 May 25;12(6):635-643. doi: 10.1093/ecco-jcc/jjy004.</mixed-citation><mixed-citation xml:lang="en">Singh S, George J, Boland BS, Vande Casteele N, et al. Primary Non-Response to Tumor Necrosis Factor Antagonists is Associated with Inferior Response to Second-line Biologics in Patients with Inflammatory Bowel Diseases: A Systematic Review and Metaanalysis. J Crohns Colitis. 2018 May 25;12(6):635-643. doi: 10.1093/ecco-jcc/jjy004.</mixed-citation></citation-alternatives></ref><ref id="cit92"><label>92</label><citation-alternatives><mixed-citation xml:lang="ru">Gecse KB, Végh Z, Lakatos PL. Optimizing biological therapy in Crohn's disease. Expert Rev Gastroenterol Hepatol. 2016;10(1):37-45. doi: 10.1586/17474124.2016.1096198. Epub 2015 Oct 16.</mixed-citation><mixed-citation xml:lang="en">Gecse KB, Végh Z, Lakatos PL. Optimizing biological therapy in Crohn's disease. Expert Rev Gastroenterol Hepatol. 2016;10(1):37-45. doi: 10.1586/17474124.2016.1096198. Epub 2015 Oct 16.</mixed-citation></citation-alternatives></ref><ref id="cit93"><label>93</label><citation-alternatives><mixed-citation xml:lang="ru">Kawalec P, Moćko P. An indirect comparison of ustekinumab and vedolizumab in the therapy of TNF-failure Crohn's disease patients. J Comp Eff Res. 2018 Feb;7(2):101-111. doi: 10.2217/cer2017-0041. Epub 2017 Nov 8.</mixed-citation><mixed-citation xml:lang="en">Kawalec P, Moćko P. An indirect comparison of ustekinumab and vedolizumab in the therapy of TNF-failure Crohn's disease patients. J Comp Eff Res. 2018 Feb;7(2):101-111. doi: 10.2217/cer2017-0041. Epub 2017 Nov 8.</mixed-citation></citation-alternatives></ref><ref id="cit94"><label>94</label><citation-alternatives><mixed-citation xml:lang="ru">Bressler B, Yarur A, Kopylov U, Bassel M, et al. United European Gastroenterol J. 2019:7(8 Suppl):624. Abstract P1091.</mixed-citation><mixed-citation xml:lang="en">Bressler B, Yarur A, Kopylov U, Bassel M, et al. United European Gastroenterol J. 2019:7(8 Suppl):624. Abstract P1091.</mixed-citation></citation-alternatives></ref><ref id="cit95"><label>95</label><citation-alternatives><mixed-citation xml:lang="ru">Gisbert JP1, Mar ín AC, McNicholl AG, Chaparro M. Systematic review with meta-analysis: the efficacy of a second anti-TNF in patients with inflammatory bowel disease whose previous anti-TNF treatment has failed. Aliment Pharmacol Ther. 2015 Apr;41(7):613-23. doi: 10.1111/apt.13083. Epub 2015 Feb 4.</mixed-citation><mixed-citation xml:lang="en">Gisbert JP1, Mar ín AC, McNicholl AG, Chaparro M. Systematic review with meta-analysis: the efficacy of a second anti-TNF in patients with inflammatory bowel disease whose previous anti-TNF treatment has failed. Aliment Pharmacol Ther. 2015 Apr;41(7):613-23. doi: 10.1111/apt.13083. Epub 2015 Feb 4.</mixed-citation></citation-alternatives></ref><ref id="cit96"><label>96</label><citation-alternatives><mixed-citation xml:lang="ru">Behm BW, Bickston SJ. Tumor necrosis factor-alpha antibody for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev. 2008 Jan 23;(1):CD006893. doi: 10.1002/14651858.CD006893.</mixed-citation><mixed-citation xml:lang="en">Behm BW, Bickston SJ. Tumor necrosis factor-alpha antibody for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev. 2008 Jan 23;(1):CD006893. doi: 10.1002/14651858.CD006893.</mixed-citation></citation-alternatives></ref><ref id="cit97"><label>97</label><citation-alternatives><mixed-citation xml:lang="ru">Strong SA, Koltun WA, Hyman NH, Buie WD. Standards Practice Task Force of the American Society of Colon and Rectal Surgeons. Practice parameters for the surgical management of Crohn’s disease. Dis Colon Rectum. 2007;50:1735-46.</mixed-citation><mixed-citation xml:lang="en">Strong SA, Koltun WA, Hyman NH, Buie WD. Standards Practice Task Force of the American Society of Colon and Rectal Surgeons. Practice parameters for the surgical management of Crohn’s disease. Dis Colon Rectum. 2007;50:1735-46.</mixed-citation></citation-alternatives></ref><ref id="cit98"><label>98</label><citation-alternatives><mixed-citation xml:lang="ru">Adamina M, Bonovas S, Raine T, Spinelli A, et al. ECCO Guidelines on Therapeutics in Crohn’s Disease: Surgical Treatment. Journal of Crohn's and Colitis. 2020;14(2):155-168 doi:10.1093/ecco-jcc/jjz187.</mixed-citation><mixed-citation xml:lang="en">Adamina M, Bonovas S, Raine T, Spinelli A, et al. ECCO Guidelines on Therapeutics in Crohn’s Disease: Surgical Treatment. Journal of Crohn's and Colitis. 2020;14(2):155-168 doi:10.1093/ecco-jcc/jjz187.</mixed-citation></citation-alternatives></ref><ref id="cit99"><label>99</label><citation-alternatives><mixed-citation xml:lang="ru">Lim WC, Wang Y, MacDonald JK, Hanauer S. Aminosalicylates for induction of remission or response in Crohn's disease. Cochrane Database Syst Rev. 2016 Jul 3;7:CD008870. doi: 10.1002/14651858.CD008870.pub2.</mixed-citation><mixed-citation xml:lang="en">Lim WC, Wang Y, MacDonald JK, Hanauer S. Aminosalicylates for induction of remission or response in Crohn's disease. Cochrane Database Syst Rev. 2016 Jul 3;7:CD008870. doi: 10.1002/14651858. CD008870.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit100"><label>100</label><citation-alternatives><mixed-citation xml:lang="ru">https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=33aa4f17-be46-459a-b95a-c258bb4e29b2&amp;t=</mixed-citation><mixed-citation xml:lang="en">https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=33aa4f17-be46-459a-b95a-c258bb4e29b2&amp;t=</mixed-citation></citation-alternatives></ref><ref id="cit101"><label>101</label><citation-alternatives><mixed-citation xml:lang="ru">Шапина М.В., Халиф И.Л., Нанаева Б.А. Применение цертолизумаба пэгола при болезни Крона. Обзор литературы. Колопроктология. 2016; № 3(57), c .102-108.</mixed-citation><mixed-citation xml:lang="en">Shapina M.V., Khalif I.L., Nanaeva V.A. Сertolizumab pegol in chohn's disease (review). Koloproktologia. 2016; no. 3, pp. 102-108. https://doi.org/10.33878/2073-7556-2016-0-3-102-108. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit102"><label>102</label><citation-alternatives><mixed-citation xml:lang="ru">Wang X, Shen B. Advances in Perianal Disease Associated with Crohn's Disease-Evolving Approaches. Gastrointest Endosc Clin N Am. 2019 Jul;29(3):515-530. doi: 10.1016/j.giec.2019.02.011.</mixed-citation><mixed-citation xml:lang="en">Wang X, Shen B. Advances in Perianal Disease Associated with Crohn's Disease-Evolving Approaches. Gastrointest Endosc Clin N Am. 2019 Jul;29(3):515-530. doi: 10.1016/j.giec.2019.02.011.</mixed-citation></citation-alternatives></ref><ref id="cit103"><label>103</label><citation-alternatives><mixed-citation xml:lang="ru">Prantera C, Zannoni F, Scribano ML, et al. An antibiotic regimen for the treatment of active Crohn's disease: a randomized, controlled clinical trial of metronidazole plus ciprofloxacin. Am J Gastroenterol. 1996;91:328-32.</mixed-citation><mixed-citation xml:lang="en">Prantera C, Zannoni F, Scribano ML, et al. An antibiotic regimen for the treatment of active Crohn's disease: a randomized, controlled clinical trial of metronidazole plus ciprofloxacin. Am J Gastroenterol. 1996;91:328-32.</mixed-citation></citation-alternatives></ref><ref id="cit104"><label>104</label><citation-alternatives><mixed-citation xml:lang="ru">Нанаева Б.А., Варданян А.В. Халиф И.Л. Эффективность терапии такролимусом у больных с перианальными поражениями при болезни Крона. Терапевтический архив. 2015;87(6):83-87 doi: 10.17116/terarkh201587683-87.</mixed-citation><mixed-citation xml:lang="en">Nanaeva BA, Vardanyan AV, Khalif IL. Efficiency of tacrolimus therapy for perianal Crohn's disease. Ter Arkh. 2015; no. 87(6), pp. 83-87. doi: 10.17116/terarkh201587683-87. (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit105"><label>105</label><citation-alternatives><mixed-citation xml:lang="ru">Puolanne AM, Kolho KL, Alfthan H, Färkkil ä M. Is home monitoring of inflammatory bowel disease feasible? A randomized controlled study. Scand J Gastroenterol. 2019 Jul;54(7):849-854. doi: 10.1080/00365521.2019.1618910. Epub 2019 Jul 2.</mixed-citation><mixed-citation xml:lang="en">Puolanne AM, Kolho KL, Alfthan H, Färkkil ä M. Is home monitoring of inflammatory bowel disease feasible? A randomized controlled study. Scand J Gastroenterol. 2019 Jul;54(7):849-854. doi: 10.1080/00365521.2019.1618910. Epub 2019 Jul 2.</mixed-citation></citation-alternatives></ref><ref id="cit106"><label>106</label><citation-alternatives><mixed-citation xml:lang="ru">Kato J, Yoshida T, Hiraoka S. Prediction of treatment outcome and relapse in inflammatory bowel disease. Expert Rev Clin Immunol. 2019 Jun;15(6):667-677. doi: 10.1080/1744666X.2019.1593140. Epub 2019 Mar 20.</mixed-citation><mixed-citation xml:lang="en">Kato J, Yoshida T, Hiraoka S. Prediction of treatment outcome and relapse in inflammatory bowel disease. Expert Rev Clin Immunol. 2019 Jun;15(6):667-677. doi: 10.1080/1744666X.2019.1593140. Epub 2019 Mar 20.</mixed-citation></citation-alternatives></ref><ref id="cit107"><label>107</label><citation-alternatives><mixed-citation xml:lang="ru">Князев О.В., Каграманова А.В., Корнеева И.А. и соавт. Значение фекального кальпротектина в мониторинге активности воспалительных заболеваний кишечника. Терапевтический архив. 2019; № 91(4), с. 53-61. DOI: 10.26442/00403660.2019.04.000229.</mixed-citation><mixed-citation xml:lang="en">Knyazev OV,Kagramanova AV, Korneeva IA, Noskova KK, et al. The use of fecal calprotectin in monitoring activity of inflammatory bowel diseases. Ter Arkh. 2019 May 16; no. 91(4), pp. 53-61. doi: 10.26442/00403660.2019.04.000229. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit108"><label>108</label><citation-alternatives><mixed-citation xml:lang="ru">Vernia F, Di Ruscio M, Stefanelli G, Viscido A, et al. Is fecal calprotectin an accurate marker in the management of Crohn's disease? J Gastroenterol Hepatol. 2020 Mar;35(3):390-400. doi: 10.1111/jgh.14950. Epub 2019 Dec 18.</mixed-citation><mixed-citation xml:lang="en">Vernia F, Di Ruscio M, Stefanelli G, Viscido A, et al. Is fecal calprotectin an accurate marker in the management of Crohn's disease? J Gastroenterol Hepatol. 2020 Mar;35(3):390-400. doi: 10.1111/jgh.14950. Epub 2019 Dec 18.</mixed-citation></citation-alternatives></ref><ref id="cit109"><label>109</label><citation-alternatives><mixed-citation xml:lang="ru">Agrawal M, Colombel JF. Treat-to-Target in Inflammatory Bowel Diseases, What Is the Target and How Do We Treat? Gastrointest Endosc Clin N Am. 2019 Jul;29(3):421-436. doi: 10.1016/j.giec.2019.02.004. Epub 2019 Apr 6.</mixed-citation><mixed-citation xml:lang="en">Agrawal M, Colombel JF. Treat-to-Target in Inflammatory Bowel Diseases, What Is the Target and How Do We Treat? Gastrointest Endosc Clin N Am. 2019 Jul;29(3):421-436. doi: 10.1016/j.giec.2019.02.004. Epub 2019 Apr 6.</mixed-citation></citation-alternatives></ref><ref id="cit110"><label>110</label><citation-alternatives><mixed-citation xml:lang="ru">Peyrin-Biroulet L, Sandborn W, Sands BE, Reinisch W, et al. Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target. Am J Gastroenterol. 2015 Sep;110(9):1324-38. doi: 10.1038/ajg.2015.233. Epub 2015 Aug 25.</mixed-citation><mixed-citation xml:lang="en">Peyrin-Biroulet L, Sandborn W, Sands BE, Reinisch W, et al. Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target. Am J Gastroenterol. 2015 Sep;110(9):1324-38. doi: 10.1038/ajg.2015.233. Epub 2015 Aug 25.</mixed-citation></citation-alternatives></ref><ref id="cit111"><label>111</label><citation-alternatives><mixed-citation xml:lang="ru">Luglio G, Giglio MC, Rispo A, Bucci C, et al. Diagnostic Accuracy of 3-Dimensional Endoanal Ultrasound in Identifying Perianal Crohn's Fistulas. Dis Colon Rectum. 2018 Aug;61(8):931-937. doi: 10.1097/DCR.0000000000001099.</mixed-citation><mixed-citation xml:lang="en">Luglio G, Giglio MC, Rispo A, Bucci C, et al. Diagnostic Accuracy of 3-Dimensional Endoanal Ultrasound in Identifying Perianal Crohn's Fistulas. Dis Colon Rectum. 2018 Aug;61(8):931-937. doi: 10.1097/DCR.0000000000001099.</mixed-citation></citation-alternatives></ref><ref id="cit112"><label>112</label><citation-alternatives><mixed-citation xml:lang="ru">Brand EC, Elias SG, Minderhoud IM, et al. Systematic review and external validation of prediction models based on symptoms and biomarkers for identifying endoscopic activity in Crohn's disease. Clin Gastroenterol Hepatol. 2019 Dec 24. pii: S15423565(19)31493-4.</mixed-citation><mixed-citation xml:lang="en">Brand EC, Elias SG, Minderhoud IM, et al. Systematic review and external validation of prediction models based on symptoms and biomarkers for identifying endoscopic activity in Crohn's disease. Clin Gastroenterol Hepatol. 2019 Dec 24. pii: S15423565(19)31493-4.</mixed-citation></citation-alternatives></ref><ref id="cit113"><label>113</label><citation-alternatives><mixed-citation xml:lang="ru">American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: controlling tuberculosis in the United States. Am J Respir Crit Care Med. 2005. 172(9): 1169-227.</mixed-citation><mixed-citation xml:lang="en">American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: controlling tuberculosis in the United States. Am J Respir Crit Care Med. 2005. 172(9): 1169-227.</mixed-citation></citation-alternatives></ref><ref id="cit114"><label>114</label><citation-alternatives><mixed-citation xml:lang="ru">Rahier JF, Magro F, Abreu C, Armuzzi A, et al. Second European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease. J Crohns Colitis. 2014 Jun;8(6):443-68. doi: 10.1016/j.crohns.2013.12.013. Epub 2014 Mar 6.</mixed-citation><mixed-citation xml:lang="en">Rahier JF, Magro F, Abreu C, Armuzzi A, et al. Second European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease. J Crohns Colitis. 2014 Jun;8(6):443-68. doi: 10.1016/j.crohns.2013.12.013. Epub 2014 Mar 6.</mixed-citation></citation-alternatives></ref><ref id="cit115"><label>115</label><citation-alternatives><mixed-citation xml:lang="ru">Rutgeerts P, Feagan BG, Lichtenstein GR, et al. Comparison of scheduled and episodic treatment strategies of infliximab in Crohn's disease. Gastroenterology. 2004;126:402-13.</mixed-citation><mixed-citation xml:lang="en">Rutgeerts P, Feagan BG, Lichtenstein GR, et al. Comparison of scheduled and episodic treatment strategies of infliximab in Crohn's disease. Gastroenterology. 2004;126:402-13.</mixed-citation></citation-alternatives></ref><ref id="cit116"><label>116</label><citation-alternatives><mixed-citation xml:lang="ru">Billioud V, Ford AC, Tedesco ED, Colombel JF, et al. Preoperative use of anti-TNF therapy and postoperative complications in inflammatory bowel diseases: a meta-analysis. Journal of Crohn's &amp; colitis. 2013;7(11):853-67.</mixed-citation><mixed-citation xml:lang="en">Billioud V, Ford AC, Tedesco ED, Colombel JF, et al. Preoperative use of anti-TNF therapy and postoperative complications in inflammatory bowel diseases: a meta-analysis. Journal of Crohn's &amp; colitis. 2013;7(11):853-67.</mixed-citation></citation-alternatives></ref><ref id="cit117"><label>117</label><citation-alternatives><mixed-citation xml:lang="ru">Kopylov U, Ben-Horin S, Zmora O, Eliakim R, et al. Anti-tumor necrosis factor and postoperative complications in Crohn's disease: systematic review and meta-analysis. Inflammatory Bowel Diseases. 2012;18(12):2404-13.</mixed-citation><mixed-citation xml:lang="en">Kopylov U, Ben-Horin S, Zmora O, Eliakim R, et al. Anti-tumor necrosis factor and postoperative complications in Crohn's disease: systematic review and meta-analysis. Inflammatory Bowel Diseases. 2012;18(12):2404-13.</mixed-citation></citation-alternatives></ref><ref id="cit118"><label>118</label><citation-alternatives><mixed-citation xml:lang="ru">Selvaggi F, Pellino G, Canonico S, Sciaudone G. Effect of preoperative biologic drugs on complications and function after restorative proctocolectomy with primary ileal pouch formation: systematic review and meta-analysis. Inflamm Bowel Dis. 2015;21(1):79-92.</mixed-citation><mixed-citation xml:lang="en">Selvaggi F, Pellino G, Canonico S, Sciaudone G. Effect of preoperative biologic drugs on complications and function after restorative proctocolectomy with primary ileal pouch formation: systematic review and meta-analysis. Inflamm Bowel Dis. 2015;21(1):79-92.</mixed-citation></citation-alternatives></ref><ref id="cit119"><label>119</label><citation-alternatives><mixed-citation xml:lang="ru">Yang ZP, Hong L, Wu Q, Wu KC, et al. Preoperative infliximab use and postoperative complications in Crohn's disease: a systematic review and meta-analysis. International Journal Of Surgery. 2014;12(3):224-30.</mixed-citation><mixed-citation xml:lang="en">Yang ZP, Hong L, Wu Q, Wu KC, et al. Preoperative infliximab use and postoperative complications in Crohn's disease: a systematic review and meta-analysis. International Journal Of Surgery. 2014;12(3):224-30.</mixed-citation></citation-alternatives></ref><ref id="cit120"><label>120</label><citation-alternatives><mixed-citation xml:lang="ru">Хачатурова Э.А., Ерошкина Т.Д., Блинова О.В., и соавт. Коррекция нарушений метаболизма в раннем послеоперационном периоде при тяжелых формах неспецифического язвенного колита и болезни Крона. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2003, т. 8, № 4, с.63-68.</mixed-citation><mixed-citation xml:lang="en">Khachaturova E.A., Eroshkina T.D., Blinova O.V., et al. Correction of metabolic disorders in the early postoperative period in severe forms of ulcerative colitis and Crohn's disease. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2003; no. 8(4), pp. 63-68. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit121"><label>121</label><citation-alternatives><mixed-citation xml:lang="ru">Korzenik JR. Massive lower gastrointestinal hemorrhage in Crohn’s disease. Curr Treat Options Gastroenterol. 2000;3:211-6.</mixed-citation><mixed-citation xml:lang="en">Korzenik JR. Massive lower gastrointestinal hemorrhage in Crohn’s disease. Curr Treat Options Gastroenterol. 2000;3:211-6.</mixed-citation></citation-alternatives></ref><ref id="cit122"><label>122</label><citation-alternatives><mixed-citation xml:lang="ru">Bundred NJ, Dixon JM, Lumsden AB, Gilmour HM, et al. Free perforation in Crohn’s colitis. A ten-year review. Dis Colon Rectum. 1985;28:35-7.</mixed-citation><mixed-citation xml:lang="en">Bundred NJ, Dixon JM, Lumsden AB, Gilmour HM, et al. Free perforation in Crohn’s colitis. A ten-year review. Dis Colon Rectum. 1985;28:35-7.</mixed-citation></citation-alternatives></ref><ref id="cit123"><label>123</label><citation-alternatives><mixed-citation xml:lang="ru">Werbin N, Haddad R, Greenberg R, Karin E, et al. Free perforation in Crohn’s disease. Isr Med Assoc J. 2003;5:175-7.</mixed-citation><mixed-citation xml:lang="en">Werbin N, Haddad R, Greenberg R, Karin E, et al. Free perforation in Crohn’s disease. Isr Med Assoc J. 2003;5:175-7.</mixed-citation></citation-alternatives></ref><ref id="cit124"><label>124</label><citation-alternatives><mixed-citation xml:lang="ru">Papi C, Festa V, Fagnani C, Stazi A, et al. Evolution of clinical behaviour in Crohn’s disease: predictive factors of penetrating complications. Dig Liver Dis. 2005;37:247-53.</mixed-citation><mixed-citation xml:lang="en">Papi C, Festa V, Fagnani C, Stazi A, et al. Evolution of clinical behaviour in Crohn’s disease: predictive factors of penetrating complications. Dig Liver Dis. 2005;37:247-53.</mixed-citation></citation-alternatives></ref><ref id="cit125"><label>125</label><citation-alternatives><mixed-citation xml:lang="ru">Poggioli G, Stocchi L, Laureti S, Selleri S, et al. Conservative surgical management of terminal ileitis: side-to-side enterocolic anastomosis. Dis Colon Rectum. 1997;40:234-7.</mixed-citation><mixed-citation xml:lang="en">Poggioli G, Stocchi L, Laureti S, Selleri S, et al. Conservative surgical management of terminal ileitis: side-to-side enterocolic anastomosis. Dis Colon Rectum. 1997;40:234-7.</mixed-citation></citation-alternatives></ref><ref id="cit126"><label>126</label><citation-alternatives><mixed-citation xml:lang="ru">Melton GB, Fazio VW, Kiran RP, He J, et al. Long-term outcomes with ileal pouch-anal anastomosis and Crohn’s disease: pouch retention and implications of delayed diagnosis. Ann Surg. 2008;248:608-16.</mixed-citation><mixed-citation xml:lang="en">Melton GB, Fazio VW, Kiran RP, He J, et al. Long-term outcomes with ileal pouch-anal anastomosis and Crohn’s disease: pouch retention and implications of delayed diagnosis. Ann Surg. 2008;248:608-16.</mixed-citation></citation-alternatives></ref><ref id="cit127"><label>127</label><citation-alternatives><mixed-citation xml:lang="ru">Panes J, Bouhnik Y, Reinisch W, Stoker J, et al. Imaging techniques for assessment of inflammatory bowel disease: joint ECCO and ESGAR evidence-based consensus guidelines. J Crohns Colitis. 2013;7(7):556-85.</mixed-citation><mixed-citation xml:lang="en">Panes J, Bouhnik Y, Reinisch W, Stoker J, et al. Imaging techniques for assessment of inflammatory bowel disease: joint ECCO and ESGAR evidence-based consensus guidelines. J Crohns Colitis. 2013;7(7):556-85.</mixed-citation></citation-alternatives></ref><ref id="cit128"><label>128</label><citation-alternatives><mixed-citation xml:lang="ru">Варданян А.В., Кашников В.Н., Болихов К.В., Халиф И.Л. Лапароскопическая илеостомия при болезни Крона. Колопроктология. 2011, № 3(37), с. 20-23.</mixed-citation><mixed-citation xml:lang="en">Vardanyan A.V., Kashnikov V.N., Bolikhov K.V., Khalif I.L. Laparoscopic ileostomy in Crohn's disease. Koloproktologia. 2011; no. 3(37), pp. 20-23. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit129"><label>129</label><citation-alternatives><mixed-citation xml:lang="ru">Воробьев Г.И., Болихов К.В., Варданян А.В. Место лапароскопической илеостомии в лечении болезни Крона толстой кишки (обзор литературы). Колопроктология. 2009, № 3(29), с. 52-58.</mixed-citation><mixed-citation xml:lang="en">Vorobyov G.I., Bolikhov K.V., Vardanyan A.V. The place of laparoscopic ileostomy in the treatment of Crohn's disease of the colon (literature review). Koloproktologia. 2009; no. 3(29), pp. 52-58. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit130"><label>130</label><citation-alternatives><mixed-citation xml:lang="ru">Sagar PM, Dozois RR, Wolff BG. Long-term results of ileal pouch-anal anastomosis in patients with Crohn’s disease. Dis Colon Rectum. 1996;39:893-8.</mixed-citation><mixed-citation xml:lang="en">Sagar PM, Dozois RR, Wolff BG. Long-term results of ileal pouch-anal anastomosis in patients with Crohn’s disease. Dis Colon Rectum. 1996;39:893-8.</mixed-citation></citation-alternatives></ref><ref id="cit131"><label>131</label><citation-alternatives><mixed-citation xml:lang="ru">Simillis C, Purkayastha S, Yamamoto T, Strong SA, et al. A meta-analysis comparing conventional end-to-end anastomosis vs. other anastomotic configurations after resection in Crohn's disease. Dis Colon Rectum. 2007;50(10):1674-87.</mixed-citation><mixed-citation xml:lang="en">Simillis C, Purkayastha S, Yamamoto T, Strong SA, et al. A meta-analysis comparing conventional end-to-end anastomosis vs. other anastomotic configurations after resection in Crohn's disease. Dis Colon Rectum. 2007;50(10):1674-87.</mixed-citation></citation-alternatives></ref><ref id="cit132"><label>132</label><citation-alternatives><mixed-citation xml:lang="ru">Mege D., Panis Y. Laparoscopic surgery for inflammatory bowel disease. Колопроктология. 2018. № 2(64), c. 14-24.</mixed-citation><mixed-citation xml:lang="en">Mege D., Panis Y. Laparoscopic surgery for inflammatory bowel disease. Колопроктология. 2018. № 2(64), c. 14-24.</mixed-citation></citation-alternatives></ref><ref id="cit133"><label>133</label><citation-alternatives><mixed-citation xml:lang="ru">Byrne CM, Solomon MJ, Young JM, Selby W, et al. Patient preferences between surgical and medical treatment in Crohn’s disease. Dis Colon Rectum. 2007;50:586-97.</mixed-citation><mixed-citation xml:lang="en">Byrne CM, Solomon MJ, Young JM, Selby W, et al. Patient preferences between surgical and medical treatment in Crohn’s disease. Dis Colon Rectum. 2007;50:586-97.</mixed-citation></citation-alternatives></ref><ref id="cit134"><label>134</label><citation-alternatives><mixed-citation xml:lang="ru">Stocchi L, Milsom JW, Fazio VW. Long-term outcomes of laparoscopic versus open ileocolic resection for Crohn’s disease: followup of a prospective randomized trial. Surgery. 2008;144:622-7.</mixed-citation><mixed-citation xml:lang="en">Stocchi L, Milsom JW, Fazio VW. Long-term outcomes of laparoscopic versus open ileocolic resection for Crohn’s disease: followup of a prospective randomized trial. Surgery. 2008;144:622-7.</mixed-citation></citation-alternatives></ref><ref id="cit135"><label>135</label><citation-alternatives><mixed-citation xml:lang="ru">Щукина О.Б., Собко В.Ю., Горбачева Д.Ш., Григорян В.В., и соавт. Прогнозирование хирургического лечения болезни Крона. Колопроктология. 2015; № 4(54), с. 33-40.</mixed-citation><mixed-citation xml:lang="en">Shchukina O., Sobko V., Gorbacheva D., Grigorian V., et al. Prediction of the surgery in Crohn`s disease. Koloproktologia. 2015; no. 4(54), pp. 33-40. (InRuss.).</mixed-citation></citation-alternatives></ref><ref id="cit136"><label>136</label><citation-alternatives><mixed-citation xml:lang="ru">Tichansky D, Cagir B, Yoo E, Marcus SM, et al. Strictureplasty for Crohn’s disease: meta-analysis. Dis Colon Rectum. 2000;43:911-9.</mixed-citation><mixed-citation xml:lang="en">Tichansky D, Cagir B, Yoo E, Marcus SM, et al. Strictureplasty for Crohn’s disease: meta-analysis. Dis Colon Rectum. 2000;43:911-9.</mixed-citation></citation-alternatives></ref><ref id="cit137"><label>137</label><citation-alternatives><mixed-citation xml:lang="ru">Reese GE, Purkayastha S, Tilney HS, von Roon A, et al. Strictureplasty vs. resection in small bowel Crohn’s disease: an evaluation of short-term outcomes and recurrence. Colorectal Dis. 2007;9:686-94.</mixed-citation><mixed-citation xml:lang="en">Reese GE, Purkayastha S, Tilney HS, von Roon A, et al. Strictureplasty vs. resection in small bowel Crohn’s disease: an evaluation of short-term outcomes and recurrence. Colorectal Dis. 2007;9:686-94.</mixed-citation></citation-alternatives></ref><ref id="cit138"><label>138</label><citation-alternatives><mixed-citation xml:lang="ru">Yamamoto T, Fazio VW, Tekkis PP. Safety and efficacy of strictureplasty for Crohn’s disease: a systematic review and metaanalysis. Dis Colon Rectum. 2007;50:1968-86.</mixed-citation><mixed-citation xml:lang="en">Yamamoto T, Fazio VW, Tekkis PP. Safety and efficacy of strictureplasty for Crohn’s disease: a systematic review and metaanalysis. Dis Colon Rectum. 2007;50:1968-86.</mixed-citation></citation-alternatives></ref><ref id="cit139"><label>139</label><citation-alternatives><mixed-citation xml:lang="ru">Caprilli R, Gassull MA, Escher JC, et al. European evidence based consensus on the diagnosis and management of Crohn’s disease: special situations. Gut. 2006;55 Suppl 1:i36-58.</mixed-citation><mixed-citation xml:lang="en">Caprilli R, Gassull MA, Escher JC, et al. European evidence based consensus on the diagnosis and management of Crohn’s disease: special situations. Gut. 2006;55 Suppl 1:i36-58.</mixed-citation></citation-alternatives></ref><ref id="cit140"><label>140</label><citation-alternatives><mixed-citation xml:lang="ru">Dietz DW, Laureti S, Strong SA, Hull TL, et al. Safety and longterm efficacy of strictureplasty in 314 patients with obstructing small bowel Crohn’s disease. J Am Coll Surg. 2001;192:330-7.</mixed-citation><mixed-citation xml:lang="en">Dietz DW, Laureti S, Strong SA, Hull TL, et al. Safety and longterm efficacy of strictureplasty in 314 patients with obstructing small bowel Crohn’s disease. J Am Coll Surg. 2001;192:330-7.</mixed-citation></citation-alternatives></ref><ref id="cit141"><label>141</label><citation-alternatives><mixed-citation xml:lang="ru">Шелыгин Ю.А., Халиф И.Л, Кашников В.Н., Болихов К.В., и соавт. Илеостомия в лечении болезни Крона толстой кишки с перианальными поражениями. Колопроктология. 2011; № 3(37), с. 133.</mixed-citation><mixed-citation xml:lang="en">Shelygin Yu.A., Khalif I.L., Kashnikov V.N., Bolikhov K.V., Vardanyan A.V. Ileostomy in treatment of Crohn's disease of the colon with perianal lesions. Koloproktologia. 2011; no. 3(37), pp. 133. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit142"><label>142</label><citation-alternatives><mixed-citation xml:lang="ru">van Dongen LM, Lubbers EJC. Perianal fistulas in patients with Crohn’s disease. Arch Surg. 1986;121:1187-90.</mixed-citation><mixed-citation xml:lang="en">van Dongen LM, Lubbers EJC. Perianal fistulas in patients with Crohn’s disease. Arch Surg. 1986;121:1187-90.</mixed-citation></citation-alternatives></ref><ref id="cit143"><label>143</label><citation-alternatives><mixed-citation xml:lang="ru">Yamamoto T, Allan RN, Keighley MR. Effect of fecal diversion alone on perianal Crohn’s disease. World J Surg. 2000;24:1258-62.</mixed-citation><mixed-citation xml:lang="en">Yamamoto T, Allan RN, Keighley MR. Effect of fecal diversion alone on perianal Crohn’s disease. World J Surg. 2000;24:1258-62.</mixed-citation></citation-alternatives></ref><ref id="cit144"><label>144</label><citation-alternatives><mixed-citation xml:lang="ru">Rutgeerts P, Geboes K, Vantrappen G, Beyls J, et al. Predictability of the postoperative course of Crohn's disease. Gastroenterology. 1990;99:956-63.</mixed-citation><mixed-citation xml:lang="en">Rutgeerts P, Geboes K, Vantrappen G, Beyls J, et al. Predictability of the postoperative course of Crohn's disease. Gastroenterology. 1990;99:956-63.</mixed-citation></citation-alternatives></ref><ref id="cit145"><label>145</label><citation-alternatives><mixed-citation xml:lang="ru">Loftus Jr EV. Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology. 2004;126(6):1504-17.</mixed-citation><mixed-citation xml:lang="en">Loftus Jr EV. Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology. 2004;126(6):1504-17.</mixed-citation></citation-alternatives></ref><ref id="cit146"><label>146</label><citation-alternatives><mixed-citation xml:lang="ru">Полетова А.В., Шапина М.В., Халиф И.Л., Варданян А.В. Эффективность послеоперационной противорецидивной терапии Адалимумабом и азатиоприном при болезни Крона. Колопроктолгия. 2018;№ 2(64), c. 73-77.</mixed-citation><mixed-citation xml:lang="en">Poletova A.V., Shapina M.V., Khalif I.L., Vardanyan A.V. the efficiency of postoperative preventive treatment by adalimumab and azathioprine in Crohn's disease. Koloproktologia. 2018; no. 2, pp. 73-77. https://doi.org/10.33878/2073-7556-2018-0-2-73-77. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit147"><label>147</label><citation-alternatives><mixed-citation xml:lang="ru">Peyrin-Biroulet, L., et al., Azathioprine and 6-mercaptopurine for the prevention of postoperative recurrence in Crohn's disease: a meta-analysis. Am J Gastroenterol. 2009. 104(8): 2089-96.</mixed-citation><mixed-citation xml:lang="en">Peyrin-Biroulet, L., et al., Azathioprine and 6-mercaptopurine for the prevention of postoperative recurrence in Crohn's disease: a meta-analysis. Am J Gastroenterol. 2009. 104(8): 2089-96.</mixed-citation></citation-alternatives></ref><ref id="cit148"><label>148</label><citation-alternatives><mixed-citation xml:lang="ru">Regueiro M, Schraut W, Baidoo L, Kip KE, et al. Infliximab prevents Crohn’s disease recurrence after ileal resection. Gastroenterology. 2009;136:441-50.</mixed-citation><mixed-citation xml:lang="en">Regueiro M, Schraut W, Baidoo L, Kip KE, et al. Infliximab prevents Crohn’s disease recurrence after ileal resection. Gastroenterology. 2009;136:441-50.</mixed-citation></citation-alternatives></ref><ref id="cit149"><label>149</label><citation-alternatives><mixed-citation xml:lang="ru">Terdiman, J.P. Prevention of postoperative recurrence in Crohn's disease. Clin Gastroenterol Hepatol. 2008;6(6):616-20.</mixed-citation><mixed-citation xml:lang="en">Terdiman, J.P. Prevention of postoperative recurrence in Crohn's disease. Clin Gastroenterol Hepatol. 2008;6(6):616-20.</mixed-citation></citation-alternatives></ref><ref id="cit150"><label>150</label><citation-alternatives><mixed-citation xml:lang="ru">Papamichael, K., et al., Adalimumab for the prevention and/ or treatment of post-operative recurrence of Crohn's disease: a prospective, two-year, single center, pilot study. J Crohns Colitis. 2012. 6(9): 924-31.</mixed-citation><mixed-citation xml:lang="en">Papamichael, K., et al., Adalimumab for the prevention and/ or treatment of post-operative recurrence of Crohn's disease: a prospective, two-year, single center, pilot study. J Crohns Colitis. 2012. 6(9): 924-31.</mixed-citation></citation-alternatives></ref><ref id="cit151"><label>151</label><citation-alternatives><mixed-citation xml:lang="ru">Халиф И.Л., Варданян А.В., Шапина М.В., Полетова А.В. Противорецидивная терапия болезни Крона в послеопера ционном периоде (обзор литературы). Колопроктология. 2017;№ 3(61), c. 63-70.</mixed-citation><mixed-citation xml:lang="en">Khalif I.L., Vardanyan A.V., Shapina M.V., Poletova A.V. postoperative preventive treatment of Crohn's disease (review). Koloproktologia. 2017; no. 3, pp. 63-70. https://doi.org/10.33878/2073-7556-2017-0-3-63-70. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit152"><label>152</label><citation-alternatives><mixed-citation xml:lang="ru">Savarino E, Bodini G, Dulbecco P, et al. Adalimumab is more effective than azathioprine and mesalamine at preventing postoperative recurrence of Crohn's disease: a randomized controlled trial. Am J Gastroenterol. 2013 Nov;108(11):1731-42. doi: 10.1038/ajg.2013.287.</mixed-citation><mixed-citation xml:lang="en">Savarino E, Bodini G, Dulbecco P, et al. Adalimumab is more effective than azathioprine and mesalamine at preventing postoperative recurrence of Crohn's disease: a randomized controlled trial. Am J Gastroenterol. 2013 Nov;108(11):1731-42. doi: 10.1038/ajg.2013.287.</mixed-citation></citation-alternatives></ref><ref id="cit153"><label>153</label><citation-alternatives><mixed-citation xml:lang="ru">Yamada A, Komaki Y, Patel N, et al. The Use of Vedolizumab in Preventing Postoperative Recurrence of Crohn's Disease. Inflamm Bowel Dis. 2018 Feb 15;24(3):502-509.</mixed-citation><mixed-citation xml:lang="en">Yamada A, Komaki Y, Patel N, et al. The Use of Vedolizumab in Preventing Postoperative Recurrence of Crohn's Disease. Inflamm Bowel Dis. 2018 Feb 15;24(3):502-509.</mixed-citation></citation-alternatives></ref><ref id="cit154"><label>154</label><citation-alternatives><mixed-citation xml:lang="ru">Lu TX, Cohen RD. Maneuvering Clinical Pathways for Crohn's Disease. Curr Gastroenterol Rep. 2019 Apr 23;21(5):20.</mixed-citation><mixed-citation xml:lang="en">Lu TX, Cohen RD. Maneuvering Clinical Pathways for Crohn's Disease. Curr Gastroenterol Rep. 2019 Apr 23;21(5):20.</mixed-citation></citation-alternatives></ref><ref id="cit155"><label>155</label><citation-alternatives><mixed-citation xml:lang="ru">Bhattacharya A1, Shen B1, Regueiro M2. Endoscopy in Postoperative Patients with Crohn's Disease or Ulcerative Colitis. Does It Translate to Better Outcomes? Gastrointest Endosc Clin N Am. 2019 Jul;29(3):487-514. doi: 10.1016/j.giec.2019.02.013.</mixed-citation><mixed-citation xml:lang="en">Bhattacharya A1, Shen B1, Regueiro M2. Endoscopy in Postoperative Patients with Crohn's Disease or Ulcerative Colitis. Does It Translate to Better Outcomes? Gastrointest Endosc Clin N Am. 2019 Jul;29(3):487-514. doi: 10.1016/j.giec.2019.02.013.</mixed-citation></citation-alternatives></ref><ref id="cit156"><label>156</label><citation-alternatives><mixed-citation xml:lang="ru">Chu KF, Moran CJ, Wu K, et al. Performance of Surveillance MR Enterography (MRE) in Asymptomatic Children and Adolescents With Crohn's Disease. J Magn Reson Imaging. 2019 Dec;50(6):19551963. doi: 10.1002/jmri.26811.</mixed-citation><mixed-citation xml:lang="en">Chu KF, Moran CJ, Wu K, et al. Performance of Surveillance MR Enterography (MRE) in Asymptomatic Children and Adolescents With Crohn's Disease. J Magn Reson Imaging. 2019 Dec;50(6):19551963. doi: 10.1002/jmri.26811.</mixed-citation></citation-alternatives></ref><ref id="cit157"><label>157</label><citation-alternatives><mixed-citation xml:lang="ru">Deepak P, Axelrad JE, Ananthakrishnan AN. The Role of the Radiologist in Determining Disease Severity in Inflammatory Bowel Diseases. Gastrointest Endosc Clin N Am. 2019 Jul;29(3):447-470. doi: 10.1016/j.giec.2019.02.006.</mixed-citation><mixed-citation xml:lang="en">Deepak P, Axelrad JE, Ananthakrishnan AN. The Role of the Radiologist in Determining Disease Severity in Inflammatory Bowel Diseases. Gastrointest Endosc Clin N Am. 2019 Jul;29(3):447-470. doi: 10.1016/j.giec.2019.02.006.</mixed-citation></citation-alternatives></ref><ref id="cit158"><label>158</label><citation-alternatives><mixed-citation xml:lang="ru">Loly C, Belaiche J, Louis E. Predictors of severe Crohn's disease. Scand J Gastroenterol. 2008;43:948-54.</mixed-citation><mixed-citation xml:lang="en">Loly C, Belaiche J, Louis E. Predictors of severe Crohn's disease. Scand J Gastroenterol. 2008;43:948-54.</mixed-citation></citation-alternatives></ref><ref id="cit159"><label>159</label><citation-alternatives><mixed-citation xml:lang="ru">Фоменко О.Ю., Ачкасов С.И., Титов А.Ю., Алешин Д.В., и соавт. Современные возможности улучшения функционального состояния запирательного аппарата у пациентов с наличием превентивных кишечных стом. Российский журнал гастроэнтеро логии, гепатологии, колопроктологии. 2015; № 5, с. 77-83.</mixed-citation><mixed-citation xml:lang="en">Fomenko O.Yu., Achkasov S.I., Titov A.Yu., Aleshin D.V., et al. Modern opportunities to improve the functional state of the obturator in patients with preventive intestinal stoma. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2015; no. 5, pp. 77-83. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit160"><label>160</label><citation-alternatives><mixed-citation xml:lang="ru">Фоменко О.Ю., Ачкасов С.И., Титов А.Ю., Джанаев Ю.А., и соавт. Роль аноректальной манометрии, БОС-терапии и тибиальной нейромодуляции в диагностике и консервативном лечении анальной инконтиненции у пожилых. Клиническая геронтология. 2015; № 5-6, с. 16-20.</mixed-citation><mixed-citation xml:lang="en">Fomenko O.Yu., Achkasov S.I., Titov A.Yu., Dzhanaev Yu.A., et al. The role of anorectal manometry, biofeedback therapy and tibial neuromodulation in the diagnosis and conservative treatment of anal incontinence in elderly. Clinical Gerontology. 2015; no. 5-6, pp. 16-20. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit161"><label>161</label><citation-alternatives><mixed-citation xml:lang="ru">Froslie KF, Jahnsen J, Moum BA, VatnMH. Group I. Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort. Gastroenterology. 2007;133:412-22.</mixed-citation><mixed-citation xml:lang="en">Froslie KF, Jahnsen J, Moum BA, VatnMH. Group I. Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort. Gastroenterology. 2007;133:412-22.</mixed-citation></citation-alternatives></ref><ref id="cit162"><label>162</label><citation-alternatives><mixed-citation xml:lang="ru">Lu C, Merrill C, Medellin A, Novak K, et al. Bowel Ultrasound State of the Art: Grayscale and Doppler Ultrasound, Contrast Enhancement, and Elastography in Crohn Disease. J Ultrasound Med. 2019 Feb;38(2):271-288. doi: 10.1002/jum.14920. Epub 2019 Jan 3.</mixed-citation><mixed-citation xml:lang="en">Lu C, Merrill C, Medellin A, Novak K, et al. Bowel Ultrasound State of the Art: Grayscale and Doppler Ultrasound, Contrast Enhancement, and Elastography in Crohn Disease. J Ultrasound Med. 2019 Feb;38(2):271-288. doi: 10.1002/jum.14920. Epub 2019 Jan 3.</mixed-citation></citation-alternatives></ref><ref id="cit163"><label>163</label><citation-alternatives><mixed-citation xml:lang="ru">Poza-Cordón J, Ripollés-Gonz ález T. Utility of abdominal ultrasonography in the diagnosis and monitoring of inflammatory bowel disease. Rev Esp Enferm Dig. 2014 Jun;106(6):395-408.</mixed-citation><mixed-citation xml:lang="en">Poza-Cordón J, Ripollés-Gonz ález T. Utility of abdominal ultrasonography in the diagnosis and monitoring of inflammatory bowel disease. Rev Esp Enferm Dig. 2014 Jun;106(6):395-408.</mixed-citation></citation-alternatives></ref><ref id="cit164"><label>164</label><citation-alternatives><mixed-citation xml:lang="ru">Calabrese E, Maaser C, Zorzi F, Kannengiesser K, et al. Bowel Ultrasonography in the Management of Crohn's Disease. A Review with Recommendations of an International Panel of Experts. Inflamm Bowel Dis. 2016 May;22(5):1168-83. doi: 10.1097/MIB.0000000000000706.</mixed-citation><mixed-citation xml:lang="en">Calabrese E, Maaser C, Zorzi F, Kannengiesser K, et al. Bowel Ultrasonography in the Management of Crohn's Disease. A Review with Recommendations of an International Panel of Experts. Inflamm Bowel Dis. 2016 May;22(5):1168-83. doi: 10.1097/MIB.0000000000000706.</mixed-citation></citation-alternatives></ref><ref id="cit165"><label>165</label><citation-alternatives><mixed-citation xml:lang="ru">Kucharzik T, Wittig BM, Helwig U, Börner N, et al. Use of Intestinal Ultrasound to Monitor Crohn's Disease Activity. ClinGastroenterol Hepatol. 2017 Apr;15(4):535-542.e2. doi: 10.1016/j.cgh.2016.10.040. Epub 2016 Nov 14.</mixed-citation><mixed-citation xml:lang="en">Kucharzik T, Wittig BM, Helwig U, Börner N, et al. Use of Intestinal Ultrasound to Monitor Crohn's Disease Activity. Clin Gastroenterol Hepatol. 2017 Apr;15(4):535-542.e2. doi: 10.1016/j.cgh.2016.10.040. Epub 2016 Nov 14.</mixed-citation></citation-alternatives></ref><ref id="cit166"><label>166</label><citation-alternatives><mixed-citation xml:lang="ru">de Ridder, Lissy; Assa, Amit ; Bronsky, Jiriet al. Use of Biosimilars in Pediatric Inflammatory Bowel Disease . An Updated Position Statement of the Pediatric IBD Porto Group of ESPGHAN. J Pediatr Gastroenterol Nutr. 2018;68:144-53.</mixed-citation><mixed-citation xml:lang="en">de Ridder, Lissy; Assa, Amit ; Bronsky, Jiriet al. Use of Biosimilars in Pediatric Inflammatory Bowel Disease . An Updated Position Statement of the Pediatric IBD Porto Group of ESPGHAN. J Pediatr Gastroenterol Nutr. 2018;68:144-53.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
