gnckКолопроктологияKoloproktologia2073-75562686-7303Russian Association of Coloproctology10.33878/2073-7556-2019-18-3-119-130gnck-1512Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWЭФФЕКТИВНОСТЬ И БЕЗОПАСНОСТЬ УСТЕКИНУМАБА ПРИ БОЛЕЗНИ КРОНА (обзор литературы)EFFICACY AND SAFETY OF USTEKINUMAB FOR CROHN’S DISEASE (reviewШапинаМ. В.ShapinaM. V.shapina.mv@yandex.ruНанаеваБ. А.NanaevaB. A.ВарданянА. В.VardanyanA. V.ФГБУ «ГНЦК им. А.Н. Рыжих» Минздрава РоссииРоссияState Scientific Centre of Coloproctology of the Ministry of Healthcare of RussiaRussian Federation201923082019183(69)119130Copyright © Шапина М.В., Нанаева Б.А., Варданян А.В., 20192019Шапина М.В., Нанаева Б.А., Варданян А.В.Shapina M.V., Nanaeva B.A., Vardanyan A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.ruproctology.com/jour/article/view/1512

Болезнь Крона (БК) является хроническим аутоиммунным заболеванием желудочно-кишечного тракта, которое поражает, в основном, молодых людей трудоспособного возраста. До сих пор пациенты с данным заболеванием не могут быть вылечены ни с помощью консервативной терапии ни хирургическими методами. Эффективность препаратов, доступных для лечения БК, ограничена. Кроме того, их применение нередко сопровождается нежелательными явлениями. Все это рождает потребность в новых препаратах, принципиально отличающихся по механизму действия, с высокой эффективностью и хорошим профилем безопасности. Данный обзор посвящен новому биологическому препарату для лечения БК, направленному на блокирование интерлейкинов 12 и 23, которые задействованы в патогенезе воспаления при ВЗК. В обзоре представлены данные клинических испытаний препарата 2 и 3 фазы и данные, полученные в клинической практике, позволяющие делать выводы об эффективности и безопасности данного препарата, а также его месте в алгоритме лечения больных с БК.

Crohn's disease (CD) is a chronic autoimmune disease of the gastrointestinal tract, which mainly affects young people of productive age. Until now, patients with this disease cannot be cured with by conservative therapy or surgery. The effectiveness of drugs for CD is limited, and their use is often accompanied by adverse events. All this creates a need for new drugs, fundamentally different in the action, with high efficiency and a good safety profile. The review is dedicated to a new biological agent for the treatment of CD blocking interleukins 12 and 23, which are involved in the pathogenesis of inflammation in inflammatory bowel diseases. This review presents the data of phases 2 and 3 clinical trials of the agent and the data obtained in real clinical practice, allowing to conclude about the efficacy and safety, as well as its place in the treatment algorithm for CD.

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The authors declare that there are no conflicts of interest present.