References

gnck

Колопроктология

Koloproktologia

2073-75562686-7303

Russian Association of Coloproctology

10.33878/2073-7556-2019-18-3-105-118

gnck-1511

Research Article

ОБЗОР ЛИТЕРАТУРЫ

REVIEW

РОЛЬ БИОЛОГИЧЕСКИХ МАРКЕРОВ В ДИАГНОСТИКЕ ПОСЛЕОПЕРАЦИОННЫХ ИНФЕКЦИОННЫХ ОСЛОЖНЕНИЙ В КОЛОРЕКТАЛЬНОЙ ХИРУРГИИ (обзор литературы)

THE ROLE OF BIOLOGICAL MARKERS IN THE DIAGNOSIS OF POSTOPERATIVE INFECTIONS IN COLORECTAL CANCER SURGERY (review)

Ачкасов

С. А.

Achkasov

S. I.

Сухина

М. А.

Sukhina

M. A.

Москалев

А. И.

Moskalev

A. I.

Набиев

Э. Н.

Nabiev

E. N.

elnur.n@hotmail.com

ФГБУ «ГНЦК им. А.Н. Рыжих» Минздрава РоссииРоссияState Scientific Centre of Coloproctology of the Ministry of Healthcare of RussiaRussian Federation

2019

23082019

183(69)105118

2019

Ачкасов С.А., Сухина М.А., Москалев А.И., Набиев Э.Н.

Achkasov S.I., Sukhina M.A., Moskalev A.I., Nabiev E.N.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.ruproctology.com/jour/article/view/1511

Инфекционные осложнения в хирургии колоректального рака занимают ведущее место в структуре послеоперационных осложнений. Частота последних составляет 5-22%, а в 5-20% случаев подобные осложнения приводят к летальному исходу. Стоит отметить, что развитие послеоперационных осложнений приводит к снижению качества жизни пациентов, общей и безрецидивной выживаемости больных, оперированных по поводу колоректального рака. Одним из перспективных способов диагностики послеоперационных инфекционных осложнений после хирургического вмешательства является оценка уровня биологических маркеров воспаления плазмы крови. Он может применяться с целью идентификации пациентов с высокой вероятностью инфекции и быть показанием для более раннего проведения дополнительных методов диагностики осложнений. В настоящее время к биомаркерам, используемым для раннего выявления послеоперационной инфекции, относятся рост лейкоцитов в периферической крови, СРБ, ПКТ, CD64 нейтрофилов и другие. Проведено большое количество исследований по изучению уровня, однако, их результаты весьма противоречивы, и вопрос о роли данных вышеуказанных биомаркеров в диагностике послеоперационных инфекций у пациентов, перенесших оперативное вмешательство по поводу рака толстой кишки, остается открытым.

Infectious complications in colorectal cancer surgery is one of the major problems in postoperative complications structure. The frequency of the latter is 5-22%, and in 5-20% of cases such complications lead to death. It should be noted that the development of postoperative complications leads to a decrease in the quality of life of patients, general and relapse-free survival of patients operated on for colorectal cancer. One of the promising ways to diagnose postoperative infectious complications after surgery is to assess the level of biological markers of plasma inflammation. It can be used to identify patients with a high probability of infection and be an indication for earlier additional methods of diagnosing complications. Currently, biomarkers that are used for early postoperative infection detection include increase in the leukocytes level in peripheral blood, CRP, PCT, CD64 neutrophils and others. Despite the large number of studies, the question of the role of these biomarkers in postoperative infections diagnosis in the patients who under went colorectal cancer surgery remains unclear.

колоректальная хирургиярак ободочной кишкирак прямой кишкибиомаркеры воспаленияинфекционные осложнения области хирургического вмешательстваСРБПКТCD64 нейтрофилыHLA-DR моноциты

colorectal surgeryrectal cancercolon cancerinflammatory biomarkerssurgical site infectionCRPPCTCD64 neutrophilsHLA-DR monocytes

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The authors declare that there are no conflicts of interest present.