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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gnck</journal-id><journal-title-group><journal-title xml:lang="ru">Колопроктология</journal-title><trans-title-group xml:lang="en"><trans-title>Koloproktologia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-7556</issn><issn pub-type="epub">2686-7303</issn><publisher><publisher-name>Russian Association of Coloproctology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33878/2073-7556-2018-0-3-103-114</article-id><article-id custom-type="elpub" pub-id-type="custom">gnck-1147</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>ПЕРОРАЛЬНАЯ АНТИБИОТИКОПРОФИЛАКТИКА В КОЛОРЕКТАЛЬНОЙ ХИРУРГИИ (систематический обзор литературы и сетевой метаанализ)</article-title><trans-title-group xml:lang="en"><trans-title>ORAL ANTIBIOTIC PROPHYLAXIS IN COLORECTAL SURGERY (systematic review and network meta-analysis)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шелыгин</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shelygin</surname><given-names>Yu. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нагудов</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Nagudov</surname><given-names>M. A.</given-names></name></name-alternatives><email xlink:type="simple">info@gnck.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пономаренко</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ponomarenko</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рыбаков</surname><given-names>Е. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Rybakov</surname><given-names>E. G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «ГНЦК им. А.Н.Рыжих» Минздрава России; ФГБОУ ДПО РМАНПО Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Scientific Centre of Coloproctology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ «ГНЦК им. А.Н.Рыжих» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Scientific Centre of Coloproctology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>30</day><month>09</month><year>2018</year></pub-date><volume>0</volume><issue>3</issue><fpage>103</fpage><lpage>114</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шелыгин Ю.А., Нагудов М.А., Пономаренко А.А., Рыбаков Е.Г., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Шелыгин Ю.А., Нагудов М.А., Пономаренко А.А., Рыбаков Е.Г.</copyright-holder><copyright-holder xml:lang="en">Shelygin Y.A., Nagudov M.A., Ponomarenko A.A., Rybakov E.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ruproctology.com/jour/article/view/1147">https://www.ruproctology.com/jour/article/view/1147</self-uri><kwd-group xml:lang="ru"><kwd>пероральная антибиотикопрофилактика</kwd><kwd>инфекционные осложнения</kwd><kwd>колоректальная хирургия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>oral antibiotic prophylaxis</kwd><kwd>surgical site infections</kwd><kwd>colorectal surgery</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Eagye, K.J. Deep and organ/space infections in patients undergoing elective colorectal surgery: incidence and impact on hospital length of stay and costs / K.J.Eagye, D.P.Nicolau et al. // Am. J. Surg. United States. - 2009. - v. 198. - № 3. - p. 359-367.</mixed-citation><mixed-citation xml:lang="en">Eagye, K.J. Deep and organ/space infections in patients undergoing elective colorectal surgery: incidence and impact on hospital length of stay and costs / K.J.Eagye, D.P.Nicolau et al. // Am. J. Surg. United States. - 2009. - v. 198. - № 3. - p. 359-367.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Horan, T.C. CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. / T.C.Horan, R.P.Gaynes, W.J.Martone et al. // Am. J. Infect. Control. United States/ - 1992. - v. 20. - № 5. - p. 271-274.</mixed-citation><mixed-citation xml:lang="en">Horan, T.C. CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. / T.C.Horan, R.P.Gaynes, W.J.Martone et al. // Am. J. Infect. Control. United States/ - 1992. - v. 20. - № 5. - p. 271-274.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Mangram, A.J. Guideline for Prevention of Surgical Site Infection, 1999. Centers for Disease Control and Prevention (CDC) Hospital Infection Control Practices Advisory Committee. / A.J.Mangram, T.C.Horan, M.L.Pearson et al. // Am. J. Infect. Control. United States/ - 1999. - v. 27. - № 2. - p. 97-132.</mixed-citation><mixed-citation xml:lang="en">Mangram, A.J. Guideline for Prevention of Surgical Site Infection, 1999. Centers for Disease Control and Prevention (CDC) Hospital Infection Control Practices Advisory Committee. / A.J.Mangram, T.C.Horan, M.L.Pearson et al. // Am. J. Infect. Control. United States/ - 1999. - v. 27. - № 2. - p. 97-132.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Cao, F. Mechanical bowel preparation for elective colorectal surgery: updated systematic review and meta-analysis. / F.Cao, J.Li, F.Li et al. // Int. J. Colorectal Dis. Germany. - 2012. - v. 27. - № 6. -p. 803-810.</mixed-citation><mixed-citation xml:lang="en">Cao, F. Mechanical bowel preparation for elective colorectal surgery: updated systematic review and meta-analysis. / F.Cao, J.Li, F.Li et al. // Int. J. Colorectal Dis. Germany. - 2012. - v. 27. - № 6. -p. 803-810.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Condon, R.E. Oral antibiotics in elective colorectal operations. / R.E.Condon, R.L.Nichols et al. // Surgery, gynecology &amp; obstetrics. United States. -1978. - v. 147. - № 3. - p. 412-413.</mixed-citation><mixed-citation xml:lang="en">Condon, R.E. Oral antibiotics in elective colorectal operations. / R.E.Condon, R.L.Nichols et al. // Surgery, gynecology &amp; obstetrics. United States. -1978. - v. 147. - № 3. - p. 412-413.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Vargish, T. A randomized prospective evaluation of orally administered antibiotics in operations on the colon. / T.Vargish, L.C.Crawford, R.A.Stallings et al. // Surg. Gynecol. Obstet. United States. - 1978. -v. 146. - № 2. - p. 193-198.</mixed-citation><mixed-citation xml:lang="en">Vargish, T. A randomized prospective evaluation of orally administered antibiotics in operations on the colon. / T.Vargish, L.C.Crawford, R.A.Stallings et al. // Surg. Gynecol. Obstet. United States. - 1978. -v. 146. - № 2. - p. 193-198.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Matheson, D.M. Randomized multicentre trial of oral bowel preparation and antimicrobials for elective colorectal operations. / D.M.Matheson, Y.Arabi, D.Baxter-Smith et al. // Br. J. Surg. England. -1978. - v. 65. - № 9. - p. 597-600.</mixed-citation><mixed-citation xml:lang="en">Matheson, D.M. Randomized multicentre trial of oral bowel preparation and antimicrobials for elective colorectal operations. / D.M.Matheson, Y.Arabi, D.Baxter-Smith et al. // Br. J. Surg. England. -1978. - v. 65. - № 9. - p. 597-600.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Bartlett, J.G. Veterans Administration Cooperative Study on Bowel Preparation for Elective Colorectal Operations: impact of oral antibiotic regimen on colonic flora, wound irrigation cultures and bacteriology of septic complications. / J.G.Bartlett, R.E.Condon, S.L.Gorbach et al. // Ann. Surg. United States. -1978. - v. 188. - № 2. - p. 249-254.</mixed-citation><mixed-citation xml:lang="en">Bartlett, J.G. Veterans Administration Cooperative Study on Bowel Preparation for Elective Colorectal Operations: impact of oral antibiotic regimen on colonic flora, wound irrigation cultures and bacteriology of septic complications. / J.G.Bartlett, R.E.Condon, S.L.Gorbach et al. // Ann. Surg. United States. -1978. - v. 188. - № 2. - p. 249-254.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Keighley, M.R. Comparison between systemic and oral antimicrobial prophylaxis in colorectal surgery. / M.R.Keighley, Y.Arabi, J.Alexander-Williams et al. // Lancet (London, England), England. - 1979. - v. 1. -№ 8122. - p. 894-897.</mixed-citation><mixed-citation xml:lang="en">Keighley, M.R. Comparison between systemic and oral antimicrobial prophylaxis in colorectal surgery. / M.R.Keighley, Y.Arabi, J.Alexander-Williams et al. // Lancet (London, England), England. - 1979. - v. 1. -№ 8122. - p. 894-897.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Edmondson, H.T. Prophylactic antibiotics in colon surgery / H.T.Edmondson, J.P.Rissing // Arch. Surg. United States. - 1983. - v. 118. - № 2. - p. 227-231.</mixed-citation><mixed-citation xml:lang="en">Edmondson, H.T. Prophylactic antibiotics in colon surgery / H.T.Edmondson, J.P.Rissing // Arch. Surg. United States. - 1983. - v. 118. - № 2. - p. 227-231.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Coppa, G.F. Parenteral and oral antibiotics in elective colon and rectal surgery. A prospective, randomized trial. / G.F.Coppa, K.Eng, T.H.Gouge et al. // Am. J. Surg. United States. - 1983. - v. 145. -№ 1. - p. 62-65.</mixed-citation><mixed-citation xml:lang="en">Coppa, G.F. Parenteral and oral antibiotics in elective colon and rectal surgery. A prospective, randomized trial. / G.F.Coppa, K.Eng, T.H.Gouge et al. // Am. J. Surg. United States. - 1983. - v. 145. -№ 1. - p. 62-65.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Weaver, M. Oral neomycin and erythromycin compared with single-dose systemic metronidazole and ceftriaxone prophylaxis in elective colorectal surgery. / M.Weaver // Am. J. Surg. United States. -1986. - v. 151. - № 4. - p. 437-442.</mixed-citation><mixed-citation xml:lang="en">Weaver, M. Oral neomycin and erythromycin compared with single-dose systemic metronidazole and ceftriaxone prophylaxis in elective colorectal surgery. / M.Weaver // Am. J. Surg. United States. -1986. - v. 151. - № 4. - p. 437-442.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Condon, R.E. Efficacy of oral and systemic antibiotic prophylaxis in colorectal operations. / R.E.Condon, R.L.Nichols, J.G.Bartlett et al. // Am. J. Surg. United States. - 1986. - v. 152. - № 5. -p. 564-566.</mixed-citation><mixed-citation xml:lang="en">Condon, R.E. Efficacy of oral and systemic antibiotic prophylaxis in colorectal operations. / R.E.Condon, R.L.Nichols, J.G.Bartlett et al. // Am. J. Surg. United States. - 1986. - v. 152. - № 5. -p. 564-566.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Kling, P.A. Oral prophylaxis with neomycin and erythromycin in colorectal surgery. More proof for efficacy than failure. / P.A.Kling, S.Dahlgren et al. // Arch. Surg. United States. - 1989. - v. 124. - № 6. -p. 705-707.</mixed-citation><mixed-citation xml:lang="en">Kling, P.A. Oral prophylaxis with neomycin and erythromycin in colorectal surgery. More proof for efficacy than failure. / P.A.Kling, S.Dahlgren et al. // Arch. Surg. United States. - 1989. - v. 124. - № 6. -p. 705-707.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Schoetz, D.J. Addition of parenteral cefoxitin to regimen of oral antibiotics for elective colorectal operations. A randomized prospective study. / D.J.Schoetz, P.L.Roberts, J.J. Murray et al. // Ann. Surg. United States. - 1990. - v. 212. - № 2. -p. 209-212.</mixed-citation><mixed-citation xml:lang="en">Schoetz, D.J. Addition of parenteral cefoxitin to regimen of oral antibiotics for elective colorectal operations. A randomized prospective study. / D.J.Schoetz, P.L.Roberts, J.J. Murray et al. // Ann. Surg. United States. - 1990. - v. 212. - № 2. -p. 209-212.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Hjalmarsson, C. Orally Administered Trimethoprim-Sulfamethoxazole and Metronidazole as Infection Prophylaxis in Elective Colorectal Surgery. / C.Hjalmarsson, J.Karlberg, P.Tornqvist et al. // Surg. Infect. (Larchmt). United States. - 2015. - v. 16. -№ 5. - p. 604-610.</mixed-citation><mixed-citation xml:lang="en">Hjalmarsson, C. Orally Administered Trimethoprim-Sulfamethoxazole and Metronidazole as Infection Prophylaxis in Elective Colorectal Surgery. / C.Hjalmarsson, J.Karlberg, P.Tornqvist et al. // Surg. Infect. (Larchmt). United States. - 2015. - v. 16. -№ 5. - p. 604-610.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Anjum, N. A Randomized Control Trial of Preoperative Oral Antibiotics as Adjunct Therapy to Systemic Antibiotics for Preventing Surgical Site Infection in Clean Contaminated, Contaminated, and Dirty Type of Colorectal Surgeries. / N.Anjum, J.Ren, G.Wangi et al. // Dis. Colon Rectum. United States. -2017. - v. 60. - № 12. - p. 1291-1298.</mixed-citation><mixed-citation xml:lang="en">Anjum, N. A Randomized Control Trial of Preoperative Oral Antibiotics as Adjunct Therapy to Systemic Antibiotics for Preventing Surgical Site Infection in Clean Contaminated, Contaminated, and Dirty Type of Colorectal Surgeries. / N.Anjum, J.Ren, G.Wangi et al. // Dis. Colon Rectum. United States. -2017. - v. 60. - № 12. - p. 1291-1298.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Hata, H. Oral and Parenteral Versus Parenteral Antibiotic Prophylaxis in Elective Laparoscopic Colorectal Surgery (JMTO PREV 07-01): A Phase 3, Multicenter, Open-label, Randomized Trial. / H.Hata, T.Yamaguchi, S.Hasegawa et al. // Ann. Surg. United States. - 2016. - v. 263. - № 6. - p. 1085-1091.</mixed-citation><mixed-citation xml:lang="en">Hata, H. Oral and Parenteral Versus Parenteral Antibiotic Prophylaxis in Elective Laparoscopic Colorectal Surgery (JMTO PREV 07-01): A Phase 3, Multicenter, Open-label, Randomized Trial. / H.Hata, T.Yamaguchi, S.Hasegawa et al. // Ann. Surg. United States. - 2016. - v. 263. - № 6. - p. 1085-1091.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Ikeda, A. Randomized clinical trial of oral and intravenous versus intravenous antibiotic prophylaxis for laparoscopic colorectal resection. / A.Ikeda, T.Konishi, M.Ueno et al. // Br. J. Surg. England. -2016. - v. 103. - № 12. - p. 1608-1615.</mixed-citation><mixed-citation xml:lang="en">Ikeda, A. Randomized clinical trial of oral and intravenous versus intravenous antibiotic prophylaxis for laparoscopic colorectal resection. / A.Ikeda, T.Konishi, M.Ueno et al. // Br. J. Surg. England. -2016. - v. 103. - № 12. - p. 1608-1615.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Kobayashi, M. Randomized clinical trial comparing intravenous antimicrobial prophylaxis alone with oral and intravenous antimicrobial prophylaxis for the prevention of a surgical site infection in colorectal cancer surgery. / M.Kobayashi, Y.Mohri, H.Tonouchi et al. // Surg. Today. Japan. - 2007. - v. 37, - № 5. -p. 383-388.</mixed-citation><mixed-citation xml:lang="en">Kobayashi, M. Randomized clinical trial comparing intravenous antimicrobial prophylaxis alone with oral and intravenous antimicrobial prophylaxis for the prevention of a surgical site infection in colorectal cancer surgery. / M.Kobayashi, Y.Mohri, H.Tonouchi et al. // Surg. Today. Japan. - 2007. - v. 37, - № 5. -p. 383-388.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Espin-Basany, E. Prospective, randomised study on antibiotic prophylaxis in colorectal surgery. Is it really necessary to use oral antibiotics? / E.Espin-Basany, J.L.Sanchez-Garcia, M.Lopez-Cano et al. // Int. J. Colorectal Dis. Germany. - 2005. - v. 20. -№ 6. - p. 542-546.</mixed-citation><mixed-citation xml:lang="en">Espin-Basany, E. Prospective, randomised study on antibiotic prophylaxis in colorectal surgery. Is it really necessary to use oral antibiotics? / E.Espin-Basany, J.L.Sanchez-Garcia, M.Lopez-Cano et al. // Int. J. Colorectal Dis. Germany. - 2005. - v. 20. -№ 6. - p. 542-546.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Lewis, R.T. Oral versus systemic antibiotic prophylaxis in elective colon surgery: a randomized study and meta-analysis send a message from the 1990s. / R.T.Lewis, T.Ronald // Can. J. Surg. Canada. - 2002. - v. 45. - № 3. - p. 173-180.</mixed-citation><mixed-citation xml:lang="en">Lewis, R.T. Oral versus systemic antibiotic prophylaxis in elective colon surgery: a randomized study and meta-analysis send a message from the 1990s. / R.T.Lewis, T.Ronald // Can. J. Surg. Canada. - 2002. - v. 45. - № 3. - p. 173-180.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Ishida, H. Impact of oral antimicrobial prophylaxis on surgical site infection and methicillin-resistant Staphylococcus aureus infection after elective colorectal surgery. Results of a prospective randomized trial. / H.Ishida, M.Yokoyama, H.Nakada et al. // Surg. Today. Japan. - 2001. - v. 31. - № 11. -p. 979-983.</mixed-citation><mixed-citation xml:lang="en">Ishida, H. Impact of oral antimicrobial prophylaxis on surgical site infection and methicillin-resistant Staphylococcus aureus infection after elective colorectal surgery. Results of a prospective randomized trial. / H.Ishida, M.Yokoyama, H.Nakada et al. // Surg. Today. Japan. - 2001. - v. 31. - № 11. -p. 979-983.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor, E.W. Selective decontamination ofthe colon before elective colorectal surgery. West of Scotland Surgical Infection Study Group. / E.W.Taylor, Lindsay G. // World J. Surg. United States. - 1994. - v. 18. -№ 6. - p. 926-31-2.</mixed-citation><mixed-citation xml:lang="en">Taylor, E.W. Selective decontamination ofthe colon before elective colorectal surgery. West of Scotland Surgical Infection Study Group. / E.W.Taylor, Lindsay G. // World J. Surg. United States. - 1994. - v. 18. -№ 6. - p. 926-31-2.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Stellato, T.A. Antibiotics in elective colon surgery. A randomized trial of oral, systemic, and oral/ systemic antibiotics for prophylaxis. / T.A.Stellato, L.H.Danziger, N.Gordon et al. // Am. Surg. United States. - 1990. - v. 56. - № 4. - p. 251-254.</mixed-citation><mixed-citation xml:lang="en">Stellato, T.A. Antibiotics in elective colon surgery. A randomized trial of oral, systemic, and oral/ systemic antibiotics for prophylaxis. / T.A.Stellato, L.H.Danziger, N.Gordon et al. // Am. Surg. United States. - 1990. - v. 56. - № 4. - p. 251-254.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Nohr, M. Prophylactic single-dose fosfomycin and metronidazole compared with neomycin, bacitracin, metronidazole and ampicillin in elective colorectal operations. / M.Nohr, J.C.Andersen, K.E.Juul-Jensen et al. // Acta Chir. Scand. Sweden. - 1990. - v. 156. -№ 3. - p. 223-230.</mixed-citation><mixed-citation xml:lang="en">Nohr, M. Prophylactic single-dose fosfomycin and metronidazole compared with neomycin, bacitracin, metronidazole and ampicillin in elective colorectal operations. / M.Nohr, J.C.Andersen, K.E.Juul-Jensen et al. // Acta Chir. Scand. Sweden. - 1990. - v. 156. -№ 3. - p. 223-230.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Liberati, A. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration/ A.Liberati, D.G.Altman, J.Tetzlaff et al. // BMJ. - 2009. - v. 339. - № jul 21 1. - p. b2700-b2700.</mixed-citation><mixed-citation xml:lang="en">Liberati, A. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration/ A.Liberati, D.G.Altman, J.Tetzlaff et al. // BMJ. - 2009. - v. 339. - № jul 21 1. - p. b2700-b2700.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Wheeler, D.C. Assessing Local Model Adequacy in Bayesian Hierarchical Models Using the Partitioned Deviance Information Criterion. / D.C.Wheeler, D.A.Hickson, L.A.Waller et al. // Comput. Stat. Data Anal. Netherlands. - 2010. - v. 54. - № 6. -p. 1657-1671.</mixed-citation><mixed-citation xml:lang="en">Wheeler, D.C. Assessing Local Model Adequacy in Bayesian Hierarchical Models Using the Partitioned Deviance Information Criterion. / D.C.Wheeler, D.A.Hickson, L.A.Waller et al. // Comput. Stat. Data Anal. Netherlands. - 2010. - v. 54. - № 6. -p. 1657-1671.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Higgins, J.P.T. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. / J.P.T.Higgins, D.G.Altman et al. // Br. Med. J. - 2011. - v. 343. - p. 889-893.</mixed-citation><mixed-citation xml:lang="en">Higgins, J.P.T. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. / J.P.T.Higgins, D.G.Altman et al. // Br. Med. J. - 2011. - v. 343. - p. 889-893.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Baum, M.L. A survey of clinical trials of antibiotic prophylaxis in colon surgery: evidence against further use of no-treatment controls. / M.L.Baum, D.S.Anish et al. // N. Engl. J. Med. United States. - 1981. -v. 305. - № 14. - p. 795-799.</mixed-citation><mixed-citation xml:lang="en">Baum, M.L. A survey of clinical trials of antibiotic prophylaxis in colon surgery: evidence against further use of no-treatment controls. / M.L.Baum, D.S.Anish et al. // N. Engl. J. Med. United States. - 1981. -v. 305. - № 14. - p. 795-799.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Fujita, S. Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics. / S.Fujita, N.Saito, T.Yamada et al. // Arch. Surg. United States. - 2007. - v. 142. - № 7. -p. 657-661.</mixed-citation><mixed-citation xml:lang="en">Fujita, S. Randomized, multicenter trial of antibiotic prophylaxis in elective colorectal surgery: single dose vs 3 doses of a second-generation cephalosporin without metronidazole and oral antibiotics. / S.Fujita, N.Saito, T.Yamada et al. // Arch. Surg. United States. - 2007. - v. 142. - № 7. -p. 657-661.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Itani, K.M.F. Effect of body mass index and ertapenem versus cefotetan prophylaxis on surgical site infection in elective colorectal surgery. / K.M.F.Itani, E.H.Jensen, T.S.Finn et al. // Surg. Infect. (Larchmt). United States. - 2008. - v. 9. - № 2. -p. 131-137.</mixed-citation><mixed-citation xml:lang="en">Itani, K.M.F. Effect of body mass index and ertapenem versus cefotetan prophylaxis on surgical site infection in elective colorectal surgery. / K.M.F.Itani, E.H.Jensen, T.S.Finn et al. // Surg. Infect. (Larchmt). United States. - 2008. - v. 9. - № 2. -p. 131-137.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Deierhoi, R.J. Choice of intravenous antibiotic prophylaxis for colorectal surgery does matter. / R.J.Deierhoi, L.G.Dawes, C.Vick et al. // J. Am. Coll. Surg. United States. - 2013. - v. 217. - № 5. -p. 763-769.</mixed-citation><mixed-citation xml:lang="en">Deierhoi, R.J. Choice of intravenous antibiotic prophylaxis for colorectal surgery does matter. / R.J.Deierhoi, L.G.Dawes, C.Vick et al. // J. Am. Coll. Surg. United States. - 2013. - v. 217. - № 5. -p. 763-769.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Nelson, R.L. Antimicrobial prophylaxis for colorectal surgery. / R.L.Nelson, E.Gladman, M.Barbateskovic // Cochrane database Syst. Rev. England. - 2014. - № 5. - p. CD001181.</mixed-citation><mixed-citation xml:lang="en">Nelson, R.L. Antimicrobial prophylaxis for colorectal surgery. / R.L.Nelson, E.Gladman, M.Barbateskovic // Cochrane database Syst. Rev. England. - 2014. - № 5. - p. CD001181.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Yabata, E. A prospective, randomized clinical trial of preoperative bowel preparation for elective colorectal surgery--comparison among oral, systemic, and intraoperative luminal antibacterial preparations. / E.Yabata, S.Okabe, M.Endo et al. // J. Med. Dent. Sci. Japan. - 1997. - v. 44. - № 4. p. 75-80.</mixed-citation><mixed-citation xml:lang="en">Yabata, E. A prospective, randomized clinical trial of preoperative bowel preparation for elective colorectal surgery--comparison among oral, systemic, and intraoperative luminal antibacterial preparations. / E.Yabata, S.Okabe, M.Endo et al. // J. Med. Dent. Sci. Japan. - 1997. - v. 44. - № 4. p. 75-80.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
