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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">gnck</journal-id><journal-title-group><journal-title xml:lang="ru">Колопроктология</journal-title><trans-title-group xml:lang="en"><trans-title>Koloproktologia</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2073-7556</issn><issn pub-type="epub">2686-7303</issn><publisher><publisher-name>Russian Association of Coloproctology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33878/2073-7556-2018-0-1-57-62</article-id><article-id custom-type="elpub" pub-id-type="custom">gnck-1109</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE REPORT</subject></subj-group></article-categories><title-group><article-title>МЕСТНО-РАСПРОСТРАНЁННЫЙ РАК СИГМОВИДНОЙ КИШКИ С КАРЦИНОМАТОЗОМ И МНОГОКРАТНЫМИ РЕЦИДИВАМИ. 15 ЛЕТ НАБЛЮДЕНИЯ (клинические наблюдения)</article-title><trans-title-group xml:lang="en"><trans-title>LOCALLY-ADVANCED SIGMOID CANCER WITH CARCINOMATOSIS AND MULTIPAY RECURRENCES. 15 YEARS OF OBSERVATION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ачкасов</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Achkasov</surname><given-names>S. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лихтер</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Likhter</surname><given-names>M. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сушков</surname><given-names>О. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Sushkov</surname><given-names>O. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Назаров</surname><given-names>Илья Владимирович</given-names></name><name name-style="western" xml:lang="en"><surname>Nazarov</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">proctolog.nazarov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «ГНЦК им. А.Н.Рыжих» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Scientific Center of Coloproctology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>30</day><month>03</month><year>2018</year></pub-date><volume>0</volume><issue>1</issue><fpage>57</fpage><lpage>62</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ачкасов С.И., Лихтер М.С., Сушков О.И., Назаров И.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Ачкасов С.И., Лихтер М.С., Сушков О.И., Назаров И.В.</copyright-holder><copyright-holder xml:lang="en">Achkasov S.I., Likhter M.S., Sushkov O.I., Nazarov I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ruproctology.com/jour/article/view/1109">https://www.ruproctology.com/jour/article/view/1109</self-uri><abstract><p>Карциноматоз брюшины является фактором, значительно ухудшающим прогноз выживаемости пациентов. Однако, сочетание «агрессивной» хирургической тактики и лекарственной терапии в некоторых случаях позволяет добиться хороших результатов. В представленном клиническом примере продемонстрирована ситуация, когда при первичной операции, помимо местно-распространенной опухоли, у больной имелся крупный карциноматозный узел в большом сальнике. Циторедуктивная операция с полным объёмом циторедукции в сочетании с внутрибрюшной химиотерапией позволила обеспечить отсутствие возврата карциноматоза. В последующем больная перенесла три операции, поводом для которых послужили местные рецидивы рака ободочной кишки. Тем не менее, 15-летний период наблюдения за пациенткой свидетельствует о перспективности такого подхода, позволяющего если не вылечить пациента, то существенно увеличить продолжительность его жизни.</p></abstract><trans-abstract xml:lang="en"><p>Peritoneal carcinomatosis is a major reason for treatment failure. However, combination of «aggressive» surgical approach with chemotherapy allows achieving good results. In this clinical case, a locally advanced tumor was presented with large carcinomatous node in anomentum. Cytoreductive surgery with a complete cytoreduction in combination with intra-abdominal chemotherapy prevented generalization of carcinomatosis. Subsequently, the patient underwent three surgeries for repeated local recurrence of colon cancer. A 15-year period of observation of the patient suggests that this approach is promising, which significantly increases the length of patients life expectancy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>местный рецидив</kwd><kwd>локо-регионарный рецидив</kwd><kwd>местно-распространённый рецидив</kwd><kwd>рак ободочной кишки</kwd><kwd>повторный рецидив</kwd><kwd>карциноматоз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>local recurrence</kwd><kwd>loco-regional recurrence</kwd><kwd>colon cancer</kwd><kwd>local relapse</kwd><kwd>re-recurrence</kwd><kwd>repeated local recurrence</kwd><kwd>second local recurrence</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Каприн, А.Д. Состояние онкологической помощи населению России в 2015 году / А.Д.Каприн, В.В.Старинский, Г.В.Петрова // М.: МНИОИ им. П.А.Герцена филиал ФГБУ «НМИРЦ» Минздрава России. - 2016. - 236 с.</mixed-citation><mixed-citation xml:lang="en">Каприн, А.Д. Состояние онкологической помощи населению России в 2015 году / А.Д.Каприн, В.В.Старинский, Г.В.Петрова // М.: МНИОИ им. П.А.Герцена филиал ФГБУ «НМИРЦ» Минздрава России. - 2016. - 236 с.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ачкасов, С.И. Возможности комбинированного лечения распространенного рака сигмовидной кишки с обширным поражением мочевого пузыря / С.И.Ачкасов, М.С.Лихтер // Колопроктология. -2009. - № 4 (30). - с. 51-53.</mixed-citation><mixed-citation xml:lang="en">Ачкасов, С.И. Возможности комбинированного лечения распространенного рака сигмовидной кишки с обширным поражением мочевого пузыря / С.И.Ачкасов, М.С.Лихтер // Колопроктология. -2009. - № 4 (30). - с. 51-53.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Шелыгин, Ю.А. Повторные циторедуктивные операции с внутрибрюшной интраоперационной химиотерапией у больных раком толстой кишки с рецидивом перитонеального карциноматоза. / Ю.А.Шелыгин, О.И.Сушков, С.И.Ачкасов и соавт. // Колопроктология. - 2017. - № 4 (62) - с. 67-73</mixed-citation><mixed-citation xml:lang="en">Шелыгин, Ю.А. Повторные циторедуктивные операции с внутрибрюшной интраоперационной химиотерапией у больных раком толстой кишки с рецидивом перитонеального карциноматоза. / Ю.А.Шелыгин, О.И.Сушков, С.И.Ачкасов и соавт. // Колопроктология. - 2017. - № 4 (62) - с. 67-73</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Akiyoshi, T. Prognostic factors for survival after salvage surgery for locoregional recurrence of colon cancer / T.Akiyoshi, Y.Fujimoto, T.Konishi et al. // American Journal of Surgery. - 2011. - № 6 (201). -p. 726-733.</mixed-citation><mixed-citation xml:lang="en">Akiyoshi, T. Prognostic factors for survival after salvage surgery for locoregional recurrence of colon cancer / T.Akiyoshi, Y.Fujimoto, T.Konishi et al. // American Journal of Surgery. - 2011. - № 6 (201). -p. 726-733.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Bouchard, P. Management of Recurrent Rectal Cancer / P.Bouchard, J.Efron // Annals of Surgical Oncology. - 2010. - № 5 (17). - p. 1343-1356.</mixed-citation><mixed-citation xml:lang="en">Bouchard, P. Management of Recurrent Rectal Cancer / P.Bouchard, J.Efron // Annals of Surgical Oncology. - 2010. - № 5 (17). - p. 1343-1356.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Bowne, W.B. Operative salvage for locoregional recurrent colon cancer after curative resection: An analysis of 100 cases / W.B.Bowne, B.Lee, W.D.Wong et al. // Diseases of the Colon and Rectum. - 2005. - № 5 (48). - p. 897-909.</mixed-citation><mixed-citation xml:lang="en">Bowne, W.B. Operative salvage for locoregional recurrent colon cancer after curative resection: An analysis of 100 cases / W.B.Bowne, B.Lee, W.D.Wong et al. // Diseases of the Colon and Rectum. - 2005. - № 5 (48). - p. 897-909.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Chesney, T.R., Outcomes of resection for locoregionally recurrent colon cancer: A systematic review / T.R.Chesney, A.Nadler, S.A.Acuna et al. // Surgery. - 2016. - № 1 (160). - p. 54-66.</mixed-citation><mixed-citation xml:lang="en">Chesney, T.R., Outcomes of resection for locoregionally recurrent colon cancer: A systematic review / T.R.Chesney, A.Nadler, S.A.Acuna et al. // Surgery. - 2016. - № 1 (160). - p. 54-66.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Elferink, M. Prognostic factors for locoregional recurrences in colon cancer. / M.Elferink, O.Visser, T.Wiggers et al. // Annals of surgical oncology. -2012. - № 7 (19). - p. 2203-11.</mixed-citation><mixed-citation xml:lang="en">Elferink, M. Prognostic factors for locoregional recurrences in colon cancer. / M.Elferink, O.Visser, T.Wiggers et al. // Annals of surgical oncology. -2012. - № 7 (19). - p. 2203-11.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Harji, D.P. Surgical resection of recurrent colonic cancer. / D.P.Harji, P.M.Sagar, K.Boyle et al. // The British journal of surgery. - 2013. - № 7 (100). -p. 950-958.</mixed-citation><mixed-citation xml:lang="en">Harji, D.P. Surgical resection of recurrent colonic cancer. / D.P.Harji, P.M.Sagar, K.Boyle et al. // The British journal of surgery. - 2013. - № 7 (100). -p. 950-958.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Kogler, P. Therapeutic Management and Outcome of Locoregional Recurrence After Curative Colorectal Cancer Therapy, a Single-Center Analysis / P.Kogler, R.Kafka-Ritsch, M.Sieb et al. // Journal of Gastrointestinal Surgery. - 2014. - № 11 (18). -p. 2026-2033.</mixed-citation><mixed-citation xml:lang="en">Kogler, P. Therapeutic Management and Outcome of Locoregional Recurrence After Curative Colorectal Cancer Therapy, a Single-Center Analysis / P.Kogler, R.Kafka-Ritsch, M.Sieb et al. // Journal of Gastrointestinal Surgery. - 2014. - № 11 (18). -p. 2026-2033.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kruschewski, M. Locally recurrent colorectal cancer: results of surgical therapy. / M.Kruschewski, M.Ciurea, S.Lipka et al. // Langenbeck’s archives of surgery / Deutsche Gesellschaft für Chirurgie. - 2012. - № 7 (397). - p. 1059-67.</mixed-citation><mixed-citation xml:lang="en">Kruschewski, M. Locally recurrent colorectal cancer: results of surgical therapy. / M.Kruschewski, M.Ciurea, S.Lipka et al. // Langenbeck’s archives of surgery / Deutsche Gesellschaft für Chirurgie. - 2012. - № 7 (397). - p. 1059-67.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Pita-Fernandez, S. Intensive follow-up strategies improve outcomes in nonmetastatic colorectal cancer patients after curative surgery: a systematic review and meta-analysis / S.Pita-Fernandez, M.Alhayek-Ai, C.Gonzalez-Martin et al. // Annals of Oncology. - 2015. - № 4 (26). - p. 644-656.</mixed-citation><mixed-citation xml:lang="en">Pita-Fernandez, S. Intensive follow-up strategies improve outcomes in nonmetastatic colorectal cancer patients after curative surgery: a systematic review and meta-analysis / S.Pita-Fernandez, M.Alhayek-Ai, C.Gonzalez-Martin et al. // Annals of Oncology. - 2015. - № 4 (26). - p. 644-656.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Read, T.E. Locoregional recurrence and survival after curative resection of adenocarcinoma of the colon / T.E.Read, M.G.Mutch, B.W.Chang et al. // Journal of the American College of Surgeons. - 2002. -№ 1 (195). - p. 33-40.</mixed-citation><mixed-citation xml:lang="en">Read, T.E. Locoregional recurrence and survival after curative resection of adenocarcinoma of the colon / T.E.Read, M.G.Mutch, B.W.Chang et al. // Journal of the American College of Surgeons. - 2002. -№ 1 (195). - p. 33-40.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Sjövall, A. Loco-regional recurrence from colon cancer: a population-based study. / A.Sjövall, F.Granath, B.Cedermark et al. // Annals of surgical oncology. - 2007. - № 2 (14). - p. 432-40.</mixed-citation><mixed-citation xml:lang="en">Sjövall, A. Loco-regional recurrence from colon cancer: a population-based study. / A.Sjövall, F.Granath, B.Cedermark et al. // Annals of surgical oncology. - 2007. - № 2 (14). - p. 432-40.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Torre, L.A. Global cancer statistics, 2012. / L.A.Torre, F.Bray, R.L.Siegel et al. // CA: a cancer journal for clinicians. - 2015. - № 2 (65). - p. 87-108.</mixed-citation><mixed-citation xml:lang="en">Torre, L.A. Global cancer statistics, 2012. / L.A.Torre, F.Bray, R.L.Siegel et al. // CA: a cancer journal for clinicians. - 2015. - № 2 (65). - p. 87-108.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Yun, H.R. Local recurrence after curative resection in patients with colon and rectal cancers / H.R.Yun, L.J.Lee, J.H.Park et al. // International Journal of Colorectal Disease. - 2008. - № 11 (23). - p. 1081-1087.</mixed-citation><mixed-citation xml:lang="en">Yun, H.R. Local recurrence after curative resection in patients with colon and rectal cancers / H.R.Yun, L.J.Lee, J.H.Park et al. // International Journal of Colorectal Disease. - 2008. - № 11 (23). - p. 1081-1087.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao, J. Patterns and prognosis of locally recurrent rectal cancer following multidisciplinary treatment. / J.Zhao, C.-Z.Du, Y.-S.Sun et al. // World journal of gastroenterology. - 2012. - № 47 (18). - p. 7015-20.</mixed-citation><mixed-citation xml:lang="en">Zhao, J. Patterns and prognosis of locally recurrent rectal cancer following multidisciplinary treatment. / J.Zhao, C.-Z.Du, Y.-S.Sun et al. // World journal of gastroenterology. - 2012. - № 47 (18). - p. 7015-20.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
